导师姓名：谢希贤
性别：男
人气指数：33

所属院校：天津科技大学
所属院系：生物工程学院
职称：教授
导师类型：
招生专业：微生物与生化药学


通讯方式 :
办公电话：**
电子邮件：xixianxie@tust.edu.cn
通讯地址：天津经济技术开发区第十三大街29号，天津科技大学生物工程学院


个人简述 :
发明申请专利：[1]谷氨酸棒杆菌及采用该菌发酵生产α-酮戊二酸的方法，ZL**8.8。[2]解淀粉芽孢杆菌添加前体物发酵法生产抗病毒药物利巴韦林的生产工艺，ZL**6.3。[3]利用重组表达核糖磷酸酶生产5-肌苷酸的方法，ZL**7.8。[4]Hydroxy-and dicarboxylic-fat synthesis by microbes US 2015/** A1.[5]一种L-异亮氨酸羟化酶基因及其基因工程菌与应用，ZL**4.0。[6]一株产α-酮基丁酸的基因工程菌及其应用，**6.1。[7]一种产生四氢嘧啶的基因工程菌及其构建方法与应用，**0.2。[8]一种耐酸性苏氨酸生产菌及其构建方法与应用，**5.9。[9]一种α-酮基丁酸发酵生产工艺，**3.1。[10]一种羟基四氢嘧啶的制备方法，**9.0获奖情况：[1]芳香族氨基酸及衍生物关键技术研究与产业化，中国轻工业联合会，科技进步奖，一等奖，2015。[2]谷氨酸清洁生产和废水综合利用关键技术研究与应用，中国轻工业联合会，科技进步奖，二等奖，2015。[3]分支链氨基酸代谢调控技术及产业化，天津市，科技进步奖，二等奖，2013。[4]谷氨酸棒杆菌苏氨酸脱氨酶基因敲除及对L-亮氨酸发酵的影响，中国食品科学技术学会，科技创新奖，一等奖，2011。[5]梅花味精教师奖，二等奖，2009。

科研工作 :
[1]Ning Y Wu X Zhang C Xu Q Chen N* Xie X*. Pathway construction and metabolic engineering for fermentativeproduction of ectoine inEscherichia coli. Metabolic Engineering 2016 36:10-18.IF: 6.767[2]ZhangC Qi J Li Y Fan X Xu Q Chen N Xie X*. Production of α-ketobutyrate using engineered Escherichia coli via temperature shift. Biotechnology and Bioengineering 2016 doi: 10.1002/bit.25959. IF: 4.126[3]Gui Y Ma Y Xu Q Zhang C Xie X* Chen N. Complete genome sequence of Corynebacterium glutamicum CP a Chinese l-leucine producing strain. Journal of Biotechnology 2016 220:64-65. IF: 2.871[4]Li Y Sun L Feng J Wu R Xu Q Zhang C Chen N Xie X*. Efficient production of α-ketoglutarate in the gdh deleted Corynebacterium glutamicum by novel double-phase pH and biotin control strategy. Bioprocess and Biosystems Engineering 2016 doi:10.1007/s00449-016-1576-y. IF: 1.997[5]Zhang C Du S Liu Y Xie X Xu Q Chen N*. Strategy for enhancing adenosine production under the guidance of transcriptional and metabolite pool analysis. Biotechnol Lett. 2015 37(7):1361-1369. IF: 1.591[6]Wang J Wen B Xu Q Xie X Chen N*. Optimization of carbon source and glucose feeding strategy for improvement of L-isoleucine production by Escherichia coli. Biotechnol Biotechnol Equip. 2015 29(2):374-380.[7]Xie X Liang Y Liu H Liu Y Xu Q Zhang C Chen N.*Modification of glycolysis and its effect on the production of L-threonine in Escherichia coli. J Ind Microbiol Biotechnol 2014 41:1007-1015. IF: 2.439[8]Ma Y Yang S Liu L Xu Q Zhang C Chen N Xie X*. Fermentative production of ribavirin by overexpressing purine nucleoside phosphorylase in Bacillus.J Chem Pharm Res 2014 6(5):1377-1384. EI[9]Xu L Xie X Shi J Xu Q Chen N*.Expression of the Escherichia coli tdcB gene encoding threoninedehydratase in L-isoleucineoverproducingCorynebacterium Glutamicum Yilw. Appl Biochem Microbiol 2013 49(2) 125-129. IF: 0.658[10]Wang J Wen B Wang Jian Xu Q Zhang C Chen N XieX*. Enhancing l-isoleucine production bythrABCoverexpression combined withalaTdeletion inCorynebacterium glutamicum. Appl Biochem Biotech 2013 171(1):20-30.IF: 1.893[11]Cheng Y Zhou Y Yang L Zhang C Xu Q Xie X Chen N*. Modification of histidine biosynthesis pathway genes and the impact on production of L-histidine in Corynebacterium glutamicum. Biotechnol Lett. 2013 5(5):735-741. IF: 1.736[12]Guo X Wang J Xie X Xu Q Zhang C Chen N*. Enhancing the supply of oxaloacetate for L-glutamate production by pyc overexpression in different Corynebacterium glutamicum.Biotechnol Lett. 2013 35(6):943-950. IF: 1.736[13]Fang H Liu H Chen N* Zhang C Xie X Xu Q. Site-directed mutagenesis studies on the uridine monophosphate binding sites of feedback inhibition in carbamoyl phosphate synthetase and effects on cytidine production by Bacillus amyloliquefaciens. Can J Microbiol. 2013 59(6):374-9. IF: 1.182[14]Liang J Zhang D Guo X Xu Q Xie X Zhang C Bai G Xiao X Chen N*. At-line near-infrared spectroscopy for monitoring concentrations in temperature-triggered glutamate fermentation. Bioprocess Biosyst Eng. 2013 36(12):1879-1887. IF: 1.823[15]Fang H Xie X Xu Q Zhang C Chen N*. Enhancement of cytidine production by coexpression of gnd zwf and prs genes in recombinant Escherichia coli CYT15. Biotechnol Lett. 2013 35(2):245-251. IF: 1.736[16]Liu Q Cheng Y Xie X Xu Q Chen N*. Modification of tryptophan transport system and its impact on production of L-tryptophan in Escherichia coli. Bioresour Technol.2012 114:549-554.IF: 4.75[17]Xie X Huo W Xia J Xu Q Chen N*. Structure-activity relationship of a cold-adapted purine nucleoside phosphorylase by site-directed mutagenesis. Enzyme Microb Technol.2012 51(1):59-65.IF: 2.592[18]Xie X Xu L Shi J Xu Q Chen N*. Effect of transport proteins on L-isoleucine production with the L-isoleucine-producing strain Corynebacterium glutamicumYILW. J Ind Microbiol Biotechnol. 2012 39(10): 1549-1556. IF: 2.321[19]Shen T Liu Q Xie X Xu Q Chen N*. Improved production of tryptophan in genetically engineered Escherichia coli with TktA and PpsA overexpression. J Biomed Biotechnol. 2012 2012:605219. IF: 2.88[20]Xie X Xia J Xu Q He K Lu L Chen N*. Low-molecular-mass homotrimer purine nucleotide phosphorylase: characterization and application in enzymatic synthesis of nucleoside antiviral drugs. Biotechnol Lett. 2011 33(6):1107-1112. IF: 1.683[21]Xie X Wang G Xia J Chen N. Characterization of a recombinant cold-adapted purine nucleoside phosphorylase and its application in ribavirin bioconversion. World J Microbiol Biotechnol. 2011 27:1175-1181. IF: 1.532[22]Chen N* Xing C Xie X Xu Q. Optimization of technical conditions of producing ribavirin by Bacillussubtilis. Ann Microbiol 2009 59(3):525-530.[23]Xie X Xu L Yang F*. 2006. Proteomic analysis of the major envelope and nucleocapsid proteins of white spot syndrome virus (WSSV). J. Virol. 80:10615-10623.[24]Xie X Yang F*. 2006. White spot syndrome virus VP24 interacts with VP28 and is involved in virus infection. J. Gen. Virol. 87:1903-1908.[25]Xie X Yang F*. 2005. Interaction of white spot syndrome virus VP26 protein with actin. Virology 336:93-99.[26]Xie X Li H Xu L Yang F*. 2005. A simple and efficient method for purification of intact white spot syndrome virus (WSSV) viral particles. Virus Res. 108:63-67.