导师姓名：燕秋
性别：
人气指数：36

所属院校：大连医科大学
所属院系：基础医学院
职称：教授
导师类型：硕导
招生专业：
研究领域： 糖生物学
研究领域： 糖生物学 [收起]




通讯方式 :
办公电话：**
电子邮件：yanqiu63@126.com


个人简述 :
燕秋,博士，教授，博士、硕士生导师。现任大连医科大学基础医学院生物化学与分子生物学教研室主任。从事分子生物学及糖复合物结构和功能的研究多年。现为辽宁省重点学科主任、辽宁省糖生物学与糖工程重点实验室主任。主持自然基金多项，获辽宁省科学进步奖两项。通过省级科技成果鉴定一项。被评为大连市优秀发明家, 辽宁省 “百千万人才工程” 千层次、辽宁省教学名师等荣誉称号。

科研工作 :
承担的国家级项目：（近5年）1.国家自然科学基金 生殖内分泌激素对多囊卵巢综合征（PCOS）蛋白质糖基化的调控及致病机制的研究 2017.01-2020.12 主持；2.国家自然科学基金 胚胎发育和着床过程中O-岩藻糖化的特征及功能研究2013.01-2016.12 主持；3.国家自然科学基金 子宫内膜LeY/sLeX糖蛋白的分析及其在胚胎着床中作用的研究2011.01-2013.12 主持；
代表性论文（近5年）：1.Aziz F, Gao W, Yan Q. Fucosyltransferase-4 and Oligosaccharide Lewis Y Antigen as potentially Correlative Biomarkers of Helicobacter pylori CagA Associated Gastric Cancer. Pathol Oncol Res. 2016 Oct 18.2.Zheng Q, Dai K, Cui X, Yu M, Yang X, Yan B, Liu S, Yan Q. Leukemia inhibitory factor promote trophoblast invasion via urokinase-type plasminogen activator receptor in preeclampsia. Biomed Pharmacother. 2016 May80:102-8.3.Tian L, Shen D, Li X, Shan X, Wang X, Yan Q, Liu J. Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4.Oncotarget. 2016 Jan 127(2):1619-32.4.Aziz F, Wang X, Liu J, Yan Q. Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions. Toxicol In Vitro. 2016 Mar31:158-66.5.Gao J, Liu X, Yang F, Liu T, Yan Q, Yang X. By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis.Oncotarget. 2015 Sep 296(29):27187-98.6.Shan X, Tian LL, Zhang YM, Wang XQ, Yan Q, Liu JW. Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.Int J Oncol. 2015 Aug47(2):701-9.7.Gao W, Liang JX, Liu S, Liu C, Liu XF, Wang XQ, Yan Q. Oxidative damage of DNA induced by X-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction. Int J Clin Exp Med. 2015 Mar 158(3):3401-10.8.Gao W, Liang JX, Yan Q. Exposure to radiation therapy is associated with female reproductive health among childhood cancer survivors: a meta-analysis study. J Assist Reprod Genet. 2015 Aug32(8):1179-869.Aziz F, Yang X, Wen Q, Yan Q. A method for establishing human primary gastric epithelial cell culture from fresh surgical gastric tissues. Mol Med Rep. 2015 Aug12(2):2939-4410.Zhang YM, Zhang YY, Bulbul A, Shan X, Wang XQ, Yan Q. Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway.FEBS Lett. 2015 May 8589(11):1225-33.11.Yan X, Lin Y, Liu S, Aziz F, Yan Q.Fucosyltransferase IV (FUT4) as an effective biomarker for the diagnosis of breast cancer.Biomed Pharmacother. 2015 Mar70:299-304.12.Shan X, Aziz F, Tian LL, Wang XQ, Yan Q, Liu JW.Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression.Int J Oncol. 2015 Apr46(4):1667-76.13.Hongyan L, Shaoming T, Qiu Y.Correlation between FUT4 expression and its promoter methylation in HaCaT cells.Yi Chuan. 2015 Jan37(1):48-54.14.Aziz F, Yang X, Wang X, Yan Q.Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study.J Cancer Res Clin Oncol. 2015 Jul141(7):1221-3515.Shan X, Fu YS, Aziz F, Wang XQ, Yan Q, Liu JW. Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation. PLoS One. 2014 Dec 189(12):e115401.16.Liu S, Wang J, Qin HM, Yan XM, Yang XS, Liu C, Yan Q. LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface. Cell Death Dis. 2014 Aug 285:e1396.(IF:5.177)17.Liu S, Yang X, Wang J, Wei J, Zhang D, Wang X, Yan Q. Differential expression of LeY and fucosyltransferase IV correlates with the receptivity of RL95-2 and HEC-1A human uterine epithelial cells. Cell Biol Int. 2012 May 136(5):469-74. (IF:1.64)18.Liu S, Yang X, Liu Y, Wang X, Yan Q. sLeX/L-selectin mediates adhesion in vitro implantation model. Mol Cell Biochem. 2011 Apr350(1-2):185-92. (IF:2.33)19.Gao J, Yan Q, Liu S, Yang X.Knockdown of EpCAM enhances the chemosensitivity of breast cancer cells to 5-fluorouracil by downregulating the antiapoptotic factor Bcl-2.PLoS One. 2014 Jul 149(7):e102590. (IF:3.534)20.Gao J, Yan Q, Wang J, Liu S, Yang X. Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by AP1-Dependent EpCAM Expression in MCF-7 Cells.J Cell Physiol. 2014 Sep 9. (IF:3.874)21.Wang J, Liu S, Qin HM, Zhao Y, Wang XQ, Yan Q. Pregnancy-associated plasma protein A up-regulated by progesterone promotes adhesion and proliferation of trophoblastic cells. Int J Clin Exp Pathol. 2014 Mar 157(4):1427-37. (IF:1.783)22.Yang X, Wang J, Liu S, Yan Q. HSF1 and Sp1 regulate FUT4 gene expression and cell proliferation in breast cancer cells. J Cell Biochem. 2014 Jan115(1):168-78. (IF:3.368)23.Yang X, Liu S, Yan Q.Role of fucosyltransferase IV in epithelial-mesenchymal transition in breast cancer cells. Cell Death Dis. 2013 Jul 254:e735. (IF:5.177)24.Yang XS, Liu SA, Liu JW, Yan Q. Fucosyltransferase IV enhances expression of MMP-12 stimulated by EGF via the ERK1/2, p38 and NF-κB pathways in A431 cells. Asian Pac J Cancer Prev. 201213(4):1657-62. (IF:1.5)25.Wei X, Liu S, Wang X, Yan Q. CD82 expression alters with human endometrial cycles and affects the uterine endometrial receptivity in vitro. Exp Biol Med (Maywood). 2012 Mar 1237(3):254-62. (IF:2.8)26.Yang XS, Liu S, Liu YJ, Liu JW, Liu TJ, Wang XQ, Yan Q. Overexpression of fucosyltransferase IV promotes A431 cell proliferation through activating MAPK and PI3K/Akt signaling pathways. J Cell Physiol. 2010 Nov225(2):612-9. (IF:3.986)

教育背景 :
1995年9月——1998年7月 理学博士 大连医科大学/瑞典哥德堡大学；1987年9月——1990年7月 理学硕士 白求恩医科大学；1981年9月——1987年7月 医学学士 白求恩医科大学。