导师姓名：满淑丽
性别：女
人气指数：41

所属院校：天津科技大学
所属院系：生物工程学院
职称：副教授
导师类型：
招生专业：药理学
研究领域： [1]天然产品的提取分离与活性研究；[2]中药成分鉴定及体内代谢研究；[3]中药组方配伍机... [展开]


研究领域： [1]天然产品的提取分离与活性研究；[2]中药成分鉴定及体内代谢研究；[3]中药组方配伍机制研究 [收起]




通讯方式 :
办公电话：**
电子邮件：msl@tust.edu.cn
通讯地址：天津经济技术开发区第十三大街29号天津科技大学生物工程学院


科研工作 :
长期从事天然产物成分分离鉴定及活性开发等研究，参与课题多项，其中主持国家及省部级项目3项。尤其是对甾体皂苷类成分的鉴定抗肿瘤成药性作用机制的阐述安全性等方面开展了一系列研究。相关成果包括作为第一作者或通讯作者发表SCI论文40余篇；其中一二区论文20篇，累积影响因子120；目前论文累积引用八百余次，单篇最高引用280次。近五年发表的主要学术论文有：[1]Man SL* Zhang LL Cui JX Yang L Ma L Gao WY*. Curcumin enhances the anti-cancer effects of Paris Saponin II in lung cancer cells. Cell Proliferation. 2018: e12458.[2]Man SL* Chai HY Cui JX Yao JW Ma L Gao WY*. Antitumor and anti-metastatic mechanisms of Rhizoma paridis saponins in Lewis mice. Environmental Toxicology. 2018 33(2): 149-155.[3]Man SL Ma J Yao JW Cui JX Wang CX Li Y Ma L* Lu FP*. Systemic perturbations of key metabolites in Type 2 diabetic rats treated by polyphenols extracts from Litchi chinensis seeds. J Agric Food Chem. 2017 65(35):7698-704[4]Man SL* Li J Qiu PY Liu J Liu Z Ma L Gao WY*. Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins. Molecular Carcinogenesis. 2017 56:1405-13.[5]Man SL Qiu PY Li J Zhang LM Gao WY*. Global metabolic profiling for the study of Rhizoma Paridis Saponins induced hepatotoxicity in rats. Environmental Toxicology. 2017 32:99-108.[6]Qiu PY Sun JC Man SL* Yang H Ma L Yu P Gao WY*. Curcumin attenuates N- nitrosodiethylamine induced liver injury in mice by utilizing the method of metabonomics. J Agric Food Chem. 2017 65 (9) 2000-7.[7]Man SL Li J Liu J Fan W Liu Z Wang JM Gao WY*. Curcumin alleviated the toxic reaction of Rhizoma paridis saponins in a 45-day subchronic toxicological assessment of rats. Environmental Toxicology. 2016 31: 1935-43.[8]Qiu PY Man SL* Yang H Fan W Yu P Gao WY*. Utilization of metabonomics to identify serum biomarkers in murine H22 hepatocarcinoma and deduce antitumor mechanism of Rhizoma Paridis saponins. Chemico-biological interactions. 2016 256: 55-63.[9]Qiu PY Man SL* Li J Liu J Zhang LM Yu P Gao WY*. Overdose Intake of Curcumin Initiates the Unbalanced State of Bodies. J Agric Food Chem. 2016 64: 2765-71.[10]Qiu PY Man SL* Yang H Liu YX Liu Z Ma L Yu P Gao WY*. Metabolic regulatory network alterations reveals different therapeutic effects of cisplatin and Rhizoma paridis saponins in Lewis pulmonary adenoma mice. RSC Advances. 2016 6: 115029 - 38.[11]Liu J Liu Z Man SL* Chai HY Ma L Gao WY*. Inhibition of urethane-induced lung carcinogenesis in mice by Rhizoma paridis saponins involved EGFR/PI3K/Akt pathway. RSC Advances. 2016 6: 92330 - 4.[12]Liu J Man SL* Liu Z Ma L Gao WY*. A synergistic antitumor effect of Polyphyllin I and Formosanin C on hepatocarcinoma cells. Bioorganic & Medicinal Chemistry Letters. 2016 26: 4970-5.[13]Liu J Man SL* Li J Zhang Y Meng X Gao WY*. Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin. Environmental Toxicology and Pharmacology. 2016 46: 103-9.[14]Zhang LL Man SL* Qiu HN Liu Z Zhang M Ma L Gao WY*. Curcumin-cyclodextrin complexes enhanced the anti-cancer effects of curcumin. Environmental Toxicology and Pharmacology. 2016 48: 31-8.[15]Zhang LL Man SL* Wang YS Liu J Liu Z Yu P Gao WY*. Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells. Chemico-Biological Interactions. 2016 253: 125-133.[16]Li J Man SL* Qiu PY Fan W Zhang LM Gao WY*. Toxicological risks of Rhizoma Paridis saponins in rats involved NF-κB and Nrf2 signaling. RSC Advances. 2016 6: 31889-31897.[17]Man SL* Ma J Wang CX Li Y Gao WY Lu FP*. Chemical composition and hypoglycaemic effect of polyphenol extracts from Litchi chinensis seeds. J Funct Foods. 2016 22: 313-24.[18]Man SL Li J Fan W Chai HY Liu Z Gao WY*. Inhibition of pulmonary adenoma in diethylnitrosamine-induced rats by Rhizoma paridis saponins. J Steroid Biochem Mol Biol. 2015 154: 62-67.[19]Man SL Chai HY Qiu PY Fan W Liu Z Wang JM Gao WY*. Turmeric enhancing anti-tumor effect of Rhizoma paridis saponins by influencing their metabolic profiling in tumors of H22 hepatocarcinoma mice. Pathol Res Pract. 2015 211: 948-54.[20]Li YY Man SL* Li J Chai HY Fan W Liu Z Gao WY*. The antitumor effect of formosanin C on HepG2 cell as revealed by 1H-NMR based metabolic profiling. Chemico-Biological Interactions. 2014 220C: 193-9.[21]Man SL Fan W Liu Z Gao WY Li YY Zhang LM Liu CX. Antitumor pathway of Rhizoma Paridis Saponins based on the metabolic regulatory network alterations in H22 hepatocarcinoma mice. Steroids. 2014 84:17-21.[22]Man SL Li YY Fan W Gao WY Liu Z Zhang Y Liu CX. Combination therapy of cyclophosphamide and Rhizoma Paridis Saponins on anti-hepatocarcinoma mice and effects on cytochrome p450 enzyme expression. Steroids. 2014 80:1-6.[23]Man SL Fan W Gao WY Li YY Wang Y Liu Z Li HF. Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats. J Ethnopharmacol. 2014 151:407-412.