导师姓名：马郁芳
性别：
人气指数：41

所属院校：大连医科大学
所属院系：基础医学院
职称：教授
导师类型：
招生专业：
研究领域： 微生物生物化学与分子生物学
研究领域： 微生物生物化学与分子生物学 [收起]




通讯方式 :
办公电话：**
电子邮件：yufang_ma@hotmail.com


个人简述 :
马郁芳, 博士，教授，硕士生及博士生导师。现任大连医科大学基础医学院生物化学教研室。辽宁省新世纪百千万人才工程百层次人选，辽宁省优秀教师。

科研工作 :
承担的国家级项目：（近5年）1、国家自然科学基金 (**)：结核分枝杆菌GlmU乙酰基转移酶抑制剂的作用机制研究及抑菌效果评价 (2016.1. - 2019.12.，54.00 万)，排名1；2、大连医科大学首批 “英才工程” 优秀人才支持计划 (第二层次)，结核分枝杆菌细胞壁合成酶和细胞壁蛋白功能研究、2013/04 - 2016/03、排名1；3、国家重点基础研究发展计划、动物重要病原菌功能基因组与分子致病机理研究、课题3：病原菌表面多糖的结构与功能、2012/01 - 2016/12、排名2；4、高等学校博士学科点专项科研基金项目、结核分枝杆菌UDP-N-乙酰烯醇丙酮酸葡糖胺还原酶的结构与功能研究、2012/01 - 2014/12、排名1；5、国家自然科学基金面上项目、结核分枝杆菌磷酸葡糖胺变位酶 (GlmM) 的功能研究、2010/01 - 2012/12、排名1；
代表性论文（近5年）：例：作者、文章题目、杂志名称（影响因子）、卷期、页码1.Guoying Deng, Fei Zhang, Shufeng Yang, Jian Kang, Shanshan Sha, Yufang Ma. Mycobacterium tuberculosis Rv0431, a mannosylated protein, enhanced the mycobacterial survival and modulated cytokines production of RAW 264.7 macrophages. Microbial Pathogenesis (1.888) 2016, 100: 285-292.
2.Liming Xu, Lei Qian, Jian Kang, Shanshan Sha, Xin Yi, Shen Lu, Yufang Ma. Down-regulation of N-acetylglucosamine-1-phosphate transferase (WecA) enhanced the sensitivity of Mycobacterium smegmatis against rifampin. Journal of Applied Microbiology (2.156) 2016, 121: 966-972.
3.Qiulong Yan, Song Cui, Changming Chen, Shenghui Li, Shanshan Sha, Xianyao Wan, Yi Xin, Yufang Ma. Metagenomic analysis of sputum microbiome as a tool towards culture-independent pathogen detection of patients with ventilator-associated pneumonia. American Journal of Respiratory and Critical Care Medicine (13.118) 2016, 195(5): 636-639.
4.Xiaofeng Yao, Shanshan Sha, Yuexia Wang, Xiance Sun, Jun Cao, Jian Kang, Liping Jiang, Min Chen, Yufang Ma. Perfluorooctane sulfonate induces autophagy dependent apoptosis through Spinster 1-mediated lysosomal-mitochondrial axis and impaired mitophagy. Toxicological Sciences (3.88) 2016, 153(1): 198-211.
5.Xiaofeng Yao and Yufang Ma. Chapter 9. Organic pollutant perfluorooctane sulfonate-induced lysosomal membrane permeabilization blocks autophagy flux in human hepatoma cells. In: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Volume 9. Human Diseases and Autophagosome (1st edition) (Edited by Hayat MA). Academic Press (2016), ISBN **67. pp176-184.
6.Shanshan Sha, Xiaoxia Shi, Liming Xu, Jiabin Wen, Yi Xin and Yufang Ma. Viability, morphology and proteome of M. smegmatis MSMEG_0319 knockout strain. Proteomics (4.079) 2016, 16: 1090-1099.
7.Xiaoxia Shi, Shanshan Sha, Likun Liu, Xin Li, Yufang Ma. A microtiter plate assay for high-throughput screening of Mycobacterium tuberculosis dTDP-d-glucose-4, 6-dehydratase inhibitors. Analytical Biochemistry (2.243) 2016, 498: 53-58.
8.Jianjun Liu, Qiulong Yan, Fuwen Luo, Dong Shang, Dachang Wu, Haiquan Zhang, Xueqi Shang, Xiaoli Kang, Meyiah Abdo, Beibei Liu, Yufang Ma and Yi Xin. Acute cholecystitis associated with infection of Enterobacteriaceae from gut microbiota. Clinical Microbiology and Infection (4.575) 2015, 21(9):851.e1-9.
9.Shufeng Yang, Fei Zhang, Jian Kang, Wenli Zhang, Guoying Deng, Yi Xin, Yufang Ma. Mycobacterium tuberculosis Rv1096 protein: gene cloning, protein expression,and peptidoglycan deacetylase activity. BMC Microbiology (2.976) 2014, 14:174.
10.Xiao-Feng Yao, Jun Cao, Li-Ming Xu, Xian-Ce Sun, Jian Kang, Guang Yang, Li-Ping Jiang, Cheng-Yan Geng, Chuan-Zhou Gao, Lai-Fu Zhong, Yu-Fang Ma. Perfluorooctane sulfonate blocked autophagy flux and induced lysosome membrane permeabilization in HepG2 cells. Food and Chemical Toxicology (2.61) 2014, 67:96-104.
11.Juanjuan Qiu, Yufang Ma, Lawrence Owusu, Tao Jiang, Yi Xin. Functional analysis of serine acetyltransferase from Mycobacterium smegmatis. Journal of Basic Microbiology (1.822) 2014, 54:670-677.
12.Liming Xu, Dongting Wu, Liang Liu, Qi Zheng, Yu Song, Li Ye, Shanshan Sha, Jian Kang, Yi Xin, Yufang Ma. Characterization of mycobacterial UDP-N-acetylglucosamine enolpyruvyle transferase (MurA). Research in Microbiology (2.828) 2014, 165:91-101.
13.Huajun Li, Jya-Wei Cheng, Hui-Yuan Yu, Yi Xin, Li Tang and Yufang Ma. Effect of the antimicrobial peptide D-Nal-Pac-525 on the growth of Streptococcus mutans and its biofilm formation. Journal of Microbiology and Biotechnology (1.32), 2013, 23(8):1070-1075.
14.Jian Kang, Liming Xu, Shufeng Yang, Wendan Yu, Shuo Liu, Yi Xin and Yufang Ma. Effect of phosphoglucosamine mutase on biofilm formation and antimicrobial susceptibilities in M. smegmatis glmM gene knockdown strain. PLoS One (3.534), 2013, 8(4): e61589.
15.Juanjuan Qiu, Daiqing Wang, Yufang Ma, Tao Jiang, Yi Xin. Identification and characterization of serine acetyltransferase encoded by the Mycobacterium tuberculosis Rv2335 gene. International Journal of Molecular Medicine (1.88), 2013, 31(5):1229-1233.

教育背景 :
1997年09月 - 2000年06月，理学博士 大连医科大学；1991年01月 - 1994年05月，理学硕士 美国 North Dakota State University；1984年09月 - 1987年07月，理学硕士 北京师范大学；1980年09月 - 1984年07月，理学学士 河南师范大学。