导师姓名：贺智敏
性别：男
人气指数：48

所属院校：广州医科大学
所属院系：
职称：教授
导师类型：博导
招生专业：肿瘤学
研究领域： 恶性肿瘤发病和治疗耐受的分子机制
研究领域： 恶性肿瘤发病和治疗耐受的分子机制 [收起]




通讯方式 :
办公电话：**
电子邮件：hezhimin2005@yahoo.com


个人简述 :
贺智敏，男，医学博士，广州医学院教授，博士生导师；现任广州医学院肿瘤研究所所长兼附属肿瘤医院中心实验室主任。1982年毕业于湖南医学院医疗系，先后获学士、硕士、博士学位；1998年2007年间作为访问学者先后在香港大学微生物系、美国杜克大学癌症研究中心及美国科罗拉多大学医学中心工作4年。现担任湖南省病理生理学会副理事长兼秘书长，国际病理科学与临床杂志副主编及多家杂志编委；广州市“肿瘤学”重点扶持学科项目负责人。先后主持国家自然基金3项、省部级科研课题4项，其他项目5余项，在Nature?Medicine,Cell?stem?Cell,Cancer?Res,?Nucleic?Acids?Research,?Oncogene,?Cancer?Letter等杂志发表科研论文110余篇，其中SCI收录论文40篇。获得2项省级成果，培养博士研究生8名，硕士研究生30名,在站博士后1人。

科研工作 :
近3年以通讯作者发表的主要文章：1.??Weijia?Zhang，Meilin?Feng，Guopei?Zheng，Ye?Chen，Xuedong?Wang，Bo?Peng,Jiang?Yin,?Yanhui?Yu,?Zhimin?He?Chemoresistance?to?5-?uorouracil?induces?epithelial-?mesenchymal?transition?via?up-regulation?of?Snail?in?MCF7?human?breast?cancer?cells.?Biochem.?Biophys.?Res.?Commun.?2012,417：679-685?(IF-2.595)?2.??Guopei?Zheng,?Yan?Xiong,,?Sisi?Yi,,?Weijia?Zhang,?Bo?Peng,?Qiong?Zhang,?Zhimin?He14-3-3r?regulation?by?p53?mediates?a?chemotherapy?response?to?5-?uorouracil?in?MCF-7?breast?cancer?cells?via?Akt?inactivation??FEBS?Lett.?2012,?586：163-168??(IF-3.601)3.??Bo?Peng,?Sisi?Yi,?Yixue?Gu,?Guopei?Zheng?and?Zhimin?He?Purification?and?biochemical?characterization?of?a?novel?protein―tongue?cancer?chemotherapy?resistance-associated?protein1?(TCRP1)?Protein?Expression?and?Purification.?2012，82:360-367?(IF-1.644)4.??Weijia?Zhang,?Wei?Ding,?Ye?Chen,?Meilin?Feng,?Yongmei?Ouyang,?Yanhui?Yu,?Zhimin?He.?Upregulation?of?breast?cancer?resistance?protein?plays?a?role?in?HER2-mediated?chemoresistance?through?PI3K/Akt?and?nuclear?factor-kappa?B?signaling?pathways?in?MCF-7?breast?cancer?cells.?Acta?Biochim?Biophys.?Sin.?2011，43:647-53?(IF=1.547)5.??Yixue?Gu,?Shasha?Fan,?Yan?Xiong,?Bo?Peng,?Guopei?Zheng,?Yanhui?Yu,?Yongmei?Ouyang,Zhimin?He?Cloning?and?functional?characterization?of?TCRP1,?a?novel?gene?mediating?resistance?to?cisplatin?in?an?oral?squamous?cell?carcinoma?cell?line?.?FEBS?letters.?2011,585:881-887??(IF-3.601)6.??Gu?Y,?Fan?S,?Liu?B,?Zheng?G,?Yu?Y,?Ouyang?Y,?He?Z.?TCRP1?promotes?radioresistance?of?oral?squamous?cell?carcinoma?cells?via?Akt?signal?pathway.?Mol?Cell?Biochem.?2011，357：107-113??(IF=2.168)7.??Xuedong?Wang,?Xingang?Wu,?Chengkun?Wang,?Weijia?Zhang,?Yanhui?Yu,?Yongmei?ouyang,?Zhimin?He?Transcriptional?suppression?of?breast?cancer?resistance?protein?(BCRP)?by?wild-type?p53?through?NF-κB?pathway?in?MCF-7?cells?FEBS?letters.?2010，584：3392-3397?(IF-3.601)8.?Guopei?Zheng,?Fang?Peng,?Renkui?Ding,?Yanhui?Yu,Yongmei?Ouyang,?Zhuchu?Chen,?Zhiqiang?Xiao,?Zhimin?He.?Identification?of?proteins?responsible?for?the?multiple?drug?resistance?in?5-Fluorouracil-induced?breast?cancer?cell?using?proteomics?analysis?J.?Cancer?Res?and?Clinical?Oncology?2010,?136(10):1477-88?(IF=2.485)9.?Guopei?Zheng,?Min?Zhou,?Xinrong?Ou,?Bo?Peng,?Yanhui?Yu,?Fangren?Kong,?Yongmei?Ouyang,?Zhimin?He.?Identification?of?CA?Ⅸ?as?a?contributor?to?pingyangmycin?induced?drug?resistance?in?human?tongue?cancer?cell.?FEBS?Journal.?2010，277:4506-4518??(JF=3.129)10.?Cheng-kun?Wang,?Jian-guo?Cao,?Bo?Peng,?Yi-xue?Gu,?Guo-pei?Zheng,?Zhi-min?He.?Inhibition?of?growth?and?motility?of?human?A549?lung?carcinoma?cells?by?a?recombined?vascular?basement?membrane?derived?peptide.?Cancer?Letter??2010,?292:?261-268(IF=4.864)11.?Cheng-kun?Wang,?Jian-guo?Cao,?Jia-quan?Qu,?Bo?Peng,?Yi-xue?Gu,?Zhi-min?He.?Recombinant?vascular?basement?membrane?derived?multifunctional???peptide?blocks?endothelial?cell?angiogenesis?&?Neovascularization?J.?Cell?Biochemisthy?2010,?111(2):453-60.(IF=3.422)12.?X.?D.Wang,?B.?L.?Wang,?S.?L.?Ye,?Y.?Q.?Liao,?L.?F.?Wang?and?Z.?M.?He.??Non-invasive?foetal?RHD?genotyping?via?real-time?PCR?of?foetal?DNA?from?Chinese?RhD-negative?maternal?plasma.?Eur?J?Clin?Invest??2009?39?(7):?607?617?(IF?2.8?)13.?Janhui?Yuan,?Hui?Lv,?Bo?Peng,?Chengkun?Wang,?Yanhui?Yu,?Zhimin?He.?Role?of?BCRP?as?a?biomarker?for?predicting?resistance?to?5-fluorouracil?in?breast?cancer.?Cancer?Chemother?Pharmacol.?2009，63：1103-1110?(IF=2.74)