导师姓名：许顺江
性别：男
人气指数：50

所属院校：河北医科大学
所属院系：
职称：教授
导师类型：
招生专业：病理学与病理生理学


通讯方式 :
办公电话：0311 8591 7257
电子邮件：sjxu66@sina.com


个人简述 :
本人2005年获河北医科大学病理生理学系医学博士学位，导师：丛 斌 院士。2005年8月-2008年8月，在澳大利亚新南威尔士大学做博士后。近年来主要从事病理生理学和神经科学方面的研究工作。研究领域包括非编码RNA在神经退行性疾病和糖尿病视网膜病变发病中的作用及分子机制。特别是在老年痴呆研究方面取得重要进展，率先在我省4个城市12个行政区36个社区进行了大规模的流行病学调查，筛选出老年痴呆的易感人群，并分析了我省老年痴呆发病的相关危险因素，通过大量实验筛选出用于早期识别轻度认知功能障碍的生物标志物，为老年痴呆的早期诊断提供了依据，同时建立了完善的资料库和标本库。在国际知名杂志《Journal of Alzheimer’s Disease》（该杂志5年影响因子4.394，中科院JCR大类二区）上发表了4篇系列研究文章。现在主持国家自然科学基金面上项目1项、河北省国际合作项目1项、河北省自然科学基金项目1项、河北省应用基础研究计划重点基础研究项目1项和省政府资助临床优秀人才培养项目1项以及省卫生厅课题多项。作为主研人参与国家自然科学基金课题2项。近五年来以第一作者或通讯作者发表文章20篇，其中SCI收录10篇，累计被引用280次。获得河北医学科技奖一等奖2项。申报国家发明专利三项，已受理待批准。出版专著两部。兼任河北省实验动物学会常务理事、河北省医学会理事和河北省医学会检验医学分会委员。任《Journal of Alzheimer’s Disease》助理编辑、《Acta Pharmacologica Sinica》和《Invest Ophthalmol Vis Sci》特约审稿人。

科研工作 :
发表论文情况 以第一或通讯作者发表文章如下：1. Zhang R, Garrett Q, Zhou H, Wu X, Mao Y, Cui X, Xie B, Liu Z, Cui D, Jiang L, Zhang Q, Xu S. Upregulation of miR-195 accelerates oxidative stress-induced retinal endothelial cell injury by targeting mitofusin 2 in diabetic rats. Mol Cell Endocrinol. 2017 Sep 5452:33-43.2. Xie B, Liu Z, Liu W, Jiang L, Zhang R, Cui D, Zhang Q, Xu S. DNA Methylation and Tag SNPs of the BDNF Gene in Conversion of Amnestic Mild Cognitive Impairment into Alzheimer's Disease: A Cross-Sectional Cohort Study. J Alzheimers Dis. 201758(1):263-274.3. Xie B, Xu Y, Liu Z, Liu W, Jiang L, Zhang R, Cui D, Zhang Q, Xu S. Elevation of Peripheral BDNF Promoter Methylation Predicts Conversion from Amnestic Mild Cognitive Impairment to Alzheimer's Disease: A 5-Year Longitudinal Study. J Alzheimers Dis. 201756(1):391-401. 4. Zhang R, Zhou H, Jiang L, Mao Y, Cui X, Xie B, Cui D, Wang H, Zhang Q, Xu S. MiR-195 dependent roles of mitofusin2 in the mitochondrial dysfunction of hippocampal neurons in SAMP8 mice.Brain Res. 2016 Dec 11652:135-143. 5. Xie B, Liu Z, Jiang L, Liu W, Song M, Zhang Q, Zhang R, Cui D, Wang X, Xu S. Increased Serum miR-206 Level Predicts Conversion from Amnestic Mild Cognitive Impairment to Alzheimer's Disease: A 5-Year Follow-up Study. J Alzheimers Dis. 201755(2):509-520.6. Zhou H, Zhang R, Lu K, Yu W, Xie B, Cui D, Jiang L, Zhang Q, Xu S. Deregulation of miRNA-181c potentially contributes to the pathogenesis of AD by targeting collapsin response mediator protein 2 in mice. J Neurol Sci. 2016 Aug 15367:3-10.7. Xie B, Zhou H, Zhang R, Song M, Yu L, Wang L, Liu Z, Zhang Q, Cui D, Wang X, Xu S. Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment. J Alzheimers Dis. 201545(3):721-31. 8. Xu S, Xie B, Song M, Yu L, Wang L, An C, Zhu Q, Han K, Zhao X, Zhang R, Dong L, Chai N, Gao Y, Zhang Q, Wang X. High prevalence of mild cognitive impairment in the elderly: a community-based study in four cities of the Hebei province, china. Neuroepidemiology. 201442(2):123-30. 9. Zhang R, Zhang Q, Niu J, Lu K, Xie B, Cui D, Xu S. Screening of microRNAs associated with Alzheimer's disease using oxidative stress cell model and different strains of senescence accelerated mice. J Neurol Sci. 2014 Mar 15338(1-2):57-64.10. Xu S, Zhang R, Niu J, Cui D, Xie B, Zhang B, Lu K, Yu W, Wang X, Zhang Q. Oxidative stress mediated-alterations of the microRNA expression profile in mouse hippocampal neurons.Int J Mol Sci. 2012 Dec 1113(12):16945-60. 11. Zhang R, Niu J, Cui D, Xie B, Zhang B, Lu K, Yu W, Wang X, Zhang Q, Xu S.Neuroprotective Effects of Pre-Treament with L-Carnitine and Acetyl-L-Carnitine on Ischemic Injury In Vivo and In Vitro. Int. J. Mol. Sci. 2012, 13, 2078-2090.