导师姓名：廖化新
性别：男
人气指数：80

所属院校：暨南大学
所属院系：生命科学技术学院
职称：教授
导师类型：硕导/博导
招生专业：
研究领域： 全新的高通量全人源单克隆抗体研发综合技术平台高通量抗体重链、轻链基因线性表达系统及重组抗... [展开]


研究领域： 全新的高通量全人源单克隆抗体研发综合技术平台高通量抗体重链、轻链基因线性表达系统及重组抗体技术；利用流式细胞仪分选单个浆细胞，并从中分离全人源单克隆单抗体；利用流式细胞仪分选单个抗原特异性记忆B淋巴细胞，并从中分离全人源单克隆抗体；培养单个记忆B淋巴细胞，并从中分离全人源单克隆抗体；综合应用以上技术，建立一套完整、快速、有效的研发全人源单克隆抗体技术平台——几乎可以适用于任何需要。 [收起]




通讯方式 :
电子邮件：tliao805@jnu.edu.cn


科研工作 :
主要论文：1. Schmidt AG, Therkelsen MD, Stewart S, Kepler TB, Liao HX, Moody MA, Haynes BF, Harrison SC. Viral receptor-binding site antibodies with diverse germline origins. Cell. **(5):1026-34.2. Williams WB, Liao HX, Moody MA, Kepler TB, Alam SM, Gao F, Wiehe K, Trama AM, Jones K, Zhang R, Song H, Marshall DJ, Whitesides JF, Sawatzki K, Hua A, Liu P, Tay MZ, Seaton KE, Shen X, Foulger A, Lloyd KE, Parks R, Pollara J, Ferrari G, Yu JS, Vandergrift N, Montefiori DC, Sobieszczyk ME, Hammer S, Karuna S, Gilbert P, Grove D, Grunenberg N, McElrath MJ, Mascola JR, Koup RA, Corey L, Nabel GJ, Morgan C, Churchyard G, Maenza J, Keefer M, Graham BS, Baden LR, Tomaras GD, Haynes BF. HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies. Science (New York, NY). **(6249):aab1253.3. Gao F, Bonsignori M, Liao HX, Kumar A, Xia SM, Lu X, Cai F, Hwang KK, Song H, Zhou T, Lynch RM, Alam SM, Moody MA, Ferrari G, Berrong M, Kelsoe G, Shaw GM, Hahn BH, Montefiori DC, Kamanga G, Cohen MS, Hraber P, Kwong PD, Korber BT, Mascola JR, Kepler TB, Haynes BF. Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. Cell. **(3):481-91.4. Kepler TB, Liao HX, Alam SM, Bhaskarabhatla R, Zhang R, Yandava C, Stewart S, Anasti K, Kelsoe G, Parks R, Lloyd KE, Stolarchuk C, Pritchett J, Solomon E, Friberg E, Morris L, Karim SS, Cohen MS, Walter E, Moody MA, Wu X, Altae-Tran HR, Georgiev IS, Kwong PD, Boyd SD, Fire AZ, Mascola JR, Haynes BF. Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies. Cell Host &Microbe. 201416(3):304-13.5. Wiehe K, Easterhoff D, Luo K, Nicely NI, Bradley T, Jaeger FH, Dennison SM, Zhang R, Lloyd KE, Stolarchuk C, Parks R, Sutherland LL, Scearce RM, Morris L, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Sinangil F, Phogat S, Michael NL, Kim JH, Kelsoe G, Montefiori DC, Tomaras GD, Bonsignori M, Santra S, Kepler TB, Alam SM, Moody MA, Liao HX, Haynes BF. Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved. Immunity. 201441(6):909-18.

教育背景 :
1987-1991 美国北卡罗莱纳州教堂山分校生化和分子生物学博士学位；1973-1977 上海医科大学学士学位（现复旦大学医学院）。