导师姓名：程金科
性别：男
人气指数：92

所属院校：广西医科大学
所属院系：国家生物靶向诊治国际联合中心
职称：教授
导师类型：硕导/博导
招生专业：生物化学与分子生物学、医学生物化学与分子生物学
研究领域： 蛋白质SUMO修饰与肿瘤；调控去SUMO化蛋白酶SENP的分子机制及生物学功能；蛋白质SU... [展开]


研究领域： 蛋白质SUMO修饰与肿瘤；调控去SUMO化蛋白酶SENP的分子机制及生物学功能；蛋白质SUMO化修饰与代谢性疾病 [收起]




个人简述 :
研究员，?博士生导师。上海交通大学医学院医学科学研究院细胞信号转导研究室主任，基础医学院分子细胞生物学系系主任。1983年本科毕业于湖南农业大学兽医专业，1989年获中国农业大学动物病理学专业硕士学位，1997年获中国医学科学院/北京协和医学院肿瘤研究所细胞生物学博士学位。1998－2004年在美国The?University?of?Texas-M?D?Anderson?Cancer?Center?从事博士后研究；2004－2006年任The?University?of?Texas-M?D?Anderson?Cancer?Center，Instructor；2006－2007年任The?University?of?Texas-M?D?Anderson?Cancer?Center，Assistant?Professor。2007年任上海交通大学医学院医学科学研究院研究员至今。

科研工作 :
主要从事蛋白质修饰与细胞信号转导方面的研究，已获得国家自然科学基金、国家重大研究计划等基金资助。?主要研究方向：?1.?SUMO特异性蛋白酶与肿瘤的发生与发展。?2.?SUMO特异性蛋白酶与细胞分化的调控。?3.?细胞周期过程中蛋白质的SUMO修饰及调控机制。?招生专业：?细胞生物学?代表性论著：?1.?Cheng?J,?Yang?J,?Xia?Y,?Karin?M,?Su?B.?Syndergistic?interaction?of?MEK?kinase?2,?c-Jun?N-terminal?kinase?(JNK)?kinase?2,?and?JNK1?results?in?efficient?and?specific?JNK1?activation.?Molecular?and?Cellular?Biology,?20:2334-2342,?2000.?2.?Yang?J,?Lin?Y,?Guo?Z,?Cheng?J,?Huang?H,?Liao?W,?Chen?J,?Liu?ZG,?Su?B.?Essential?role?of?MEKK3?in?TNFa?induced?NF-kB?activation.?Nature?Immunology?,?2:620-624,?2001.?3.?Su?B,?Cheng?J,?Yang?J,?Guo?Z.?MEKK2?mediates?T?cell?receptor?signals?in?JNK?activation?and?IL-2?gene?expression.?Journal?of?Biological?Chemistry,?276:14784-14790,?2001.?4.?Guo?Z,?Clydesdale?G,?Cheng?J,?Kim?K,?Gan?L,?McConkey?DJ,?Ullrich?SE,?Zhuang?Y,?Su?B.?Disruption?of?MEKK2?in?mice?reveals?an?unexpected?role?for?MEKK2?in?modulating?T-cell?receptor?signal?transduction.?Molecular?and?Cellular?Biology,?22:5761-5768,?2002.?5.?Huang?Q,?Yang?J,?Lin?Y,?Walker?C,?Cheng?J,?Liu?ZG,?Su?B.?Differential?regulation?of?interleukin?1?receptor?and?Toll-like?receptor?signaling?by?MEKK3.?Nature?Immunology,?5:98-103,?2004.?6.?Cheng?J,?Wang?D,?Wang?Z,?Yeh?ETH.?SENP1?Enhances?Androgen?Receptor-Dependent?Transcription?through?Desumoylation?of?Histone?Deacetylase?1.?Molecular?and?Cellular?Biology,?24:6021-6028,?2004.?7.?Kho?Y,?Kim?SC,?Jiang?C,?Barma?D,?Kwon?SW,?Cheng?J,?Jaunbergs?J,?Weinbaum?C,?Tamanoi?F,?Falck?J,?Zhao?Y.?A?tagging-via-substrate?technology?for?detection?and?proteomics?of?farnesylated?proteins.?PNAS,?101:12479-12484,?2004.?8.?Cheng?J,?Zhang?D,?Kim?K,?Zhao?Y,?Su?B.?Mip1,?an?MEKK2-interacting?protein,?controls?MEKK2?dimerization?and?activation.?Molecular?and?Cellular?Biology,?25:5955-5964,?2005.?9.?Veltman?IM,?Vreede?LA,?Cheng?J,?Looijenga?LH,?Janssen?B,?Schoenmakers?EF,?Yeh?ETH,?van?Kessel?AG.?Fusion?of?the?SUMO/Sentrin-specific?protease?1?gene?SENP1?and?the?embryonic?polarity-related?mesoderm?development?gene?MESDC2?in?a?patient?with?an?infantile?teratoma?and?a?constitutional?t(1215)(q13q25).?Human?Molecular?Genetics,?14:1955-1963,?2005.?10.?Cheng?J,?Pekins?ND,?Yeh?ETH.?Differential?regulation?of?c-Jun-dependent?transcription?by?SUMO-specific?proteases.?Journal?of?Biological?Chemistry,?280:14492-14498,?2005.?11.?Cheng?J,?Yu?L,?Zhang?D,?Huang?Q,?Spencer?D,?Su?B.?Dimerization?through?the?catalytic?domain?is?essential?for?MEKK2?activation.?Journal?of?Biological?Chemistry,?280:?13477-13482,?2005.?12.?Cheng?J,?Bawa?T,?Lee?P,?Gong?L,?Yeh?ET.?Role?of?desumoylation?in?the?development?of?prostate?cancer.?Neoplasia,?8:667-676,?2006.?13.?Gao?F,?Cheng?J,?Shi?T,?and?Yeh?ET.?NEDDylation?of?a?Breast?Cancer–asociated?Protein?Recruits?a?Class?III?Histone?Deacetylase?that?Represses?NF-?B-dependent?Transcription.?Nature?Cell?Biology,?8:1171-1177,?2006.?14.?Cheng?J,?Kang?X,?Zhang?S?and?Yeh?ET.?SUMO-specific?protease?1?is?essential?for?stabilization?of?HIF1??during?hypoxia.?Cell,?131:584-595,?2007.?15.?Bawa-Khalfe?T,?Cheng?J,?Wang?Z?and?Yeh?ET.?Induction?of?the?sumo-specific?protease?1?transcription?by?the?androgen?receptor?in?prostate?cancer?cells.?Journal?of?Biological?Chemistry,?282:37341-37349,?2007.??代表性论著。