导师姓名：孙明忠
性别：
人气指数：124

所属院校：大连医科大学
所属院系：基础医学院
职称：教授
导师类型：硕导/博导
招生专业：
研究领域： 1.肿瘤转移分子机制及临床相关性研究；2.蛇毒蛋白生物活性及应用研究。
研究领域： 1.肿瘤转移分子机制及临床相关性研究；2.蛇毒蛋白生物活性及应用研究。 [收起]




通讯方式 :
办公电话：**/**
电子邮件：smzlsq@163.com


个人简述 :
孙明忠，博士，教授，硕士/博士生导师,现任大连医科大学基础医学院生物技术系教授，校学科建设处副处长。1999年毕业于中国科学院长春应用化学研究所，硕博联读，获得理学博士学位。2000.2- 2007.3，先后在法国科学院、美国爱因斯坦医学院、美国凯斯西保留地等大学进行科学研究工作。2007年获辽宁省“百千万人才工程”学者称号，2010.11-11.5，牛津大学访问学者。现为大连医学会生化专科分会委员、大连医学会医学工程专科分会委员、大连医科大学学术委员委员。已发表文章123篇，其中SCI文章75篇。

科研工作 :
主要学术任职 ：大连医科大学校学术委员会委员；大连市医学会生化专科分会委员；大连市医学会医学工程专科分会委员；中国生化与分子生物学会会员。
承担的国家级项目：（近5年）1.国家自然科学基金(**), ceRNA调控miR-330-3p、Ereg在肿瘤淋巴道转移中的作用机制及临床相关性研究,53万元, 2017.1-2020.12,项目负责人
2.国家自然科学基金(**), Anxa3,Anxa5,Anxa11调控肿瘤细胞淋巴道转移力/预警肿瘤转移及其共相关蛋白研究,55万元，2012.1-2015.12，项目负责人
代表性论文（近5年）：1.Xujuan Sun, Bin Wei, Shuqing Liu, Chunmei Guo, Na Wu, Qinlong Liu, Ming-Zhong Sun. Anxa5 mediates in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells with high lymph node metastasis potential preferentially via ERK2/p-ERK2/c-Jun/p-c-Jun(Ser73) and E-cadherin. Biomedicine & Pharmacotherapy,2016 , 84: 645-654(通讯作者).
2.Shuqing Liu, Chunmei Guo, Jiasheng Wang, Bo Wang, Houbao Qi, Ming-Zhong Sun. ANXA11 regulates the tumorigenesis, lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun. Oncotarget, 2016,7(13):16297- 16310 (通讯作者).
3.Boya Peng, Shuqing Liu, Chunmei Guo,Xujuan Sun, Ming-Zhong Sun. ANXA5 level is linked to in vitro and in vivo tumor malignancy and lymphatic metastasis of murine hepatocarcinoma cell. Future Oncology.2015, 12(1): 31-42. (通讯作者).
4.Chunmei Guo, Shuqing Liu, Panpan Dong, Dongting Zhao, Chengyi Wang, Zhiwei Tao & Ming-Zhong Sun. Akbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2 via TGF-β signal pathway. Scientific Reports. 2015, 5:18215. (通讯作者).
5.Houbao Qi, Shuqing Liu, Chunmei Guo, Jiasheng Wang, Frederick T Greenaway, Ming- Zhong Sun. Role of AnxA6 in cancers. Oncology Letters, 2015, 10: 1947-1952. (通讯作者).
6.Ming-Zhong Sun, Yanhua Cui, Chunmei Guo, Baochang Zhao, Shuqing Liu. rAdinbitor, a disintegrin from Agkistrodon halys brevicaudus stejneger, inhibits tumorigenicity of hepatocarcinoma via enhanced anti-angiogenesis and immunocompetence. Biochimie, 2015, 116: 34-52 (第一作者) .
7.Bin Wei, Chunmei Guo, Shuqing Liu, Ming-Zhong Sun. Annexin A4 and cancer. Clin Chim Acta, 2015, 447: 72-78 (通讯作者).
8.Ji Shi, Longlong Meng, Ming-Zhong Sun, Chunmei Guo , Xujuan Sun, Qiuyue Lin, Shuqing Liu.CRKL knockdown promotes in vitro proliferation, migration and invasion, in vivo tumor malignancy and lymph node metastasis of murine hepatocarcinoma Hca-P cells. Biomedicine & Pharmacotherapy 2015, 71: 84-90 (通讯作者).
9.Shuqing Liu, Jiasheng Wang, Chunmei Guo, Houbao Qi, Ming-Zhong Sun. Annexin A11 knockdown inhibits in vitro proliferation and enhances survival of Hca-F cell via Akt2/FoxO1 pathway and MMP-9 expression. Biomedicine & Pharmacotherapy, 2015, 70: 58-63 (通讯作者).
10.Chunmei Guo, Shuqing Liu, Ming-Zhong Sun. The role of CT10 regulation of kinase-like in cancer. CRKL in cancer. Future Oncology, 2014, 10(16): 2687-2697. (通讯作者).
11.Shuqing Liu, Chunmei Guo , Yimeng Guo,, Hongshan Yu, Frederick Greenaway, Ming-Zhong Sun. Comparative binding affinities of flavonoid phytochemicals with bovine serum albumin. Iranian Journal of Pharmaceutical Research, 2014, 13(3): 1019-1028. (通讯作者).
12.Jiasheng Wang, Chunmei Guo, Shuqing Liu, Houbao Qi, Yuling Yin, Rui Liang, Ming-Zhong Sun, Frederick Greenaway. Annexin A11 in disease. Clin Chim Acta,2014,431: 164-168. (通讯作者).
13.Boya Peng, Chunmei Guo, Hongwei Guan, Shuqing Liu, Ming-Zhong Sun. Annexin A5 as a potential marker in tumors. Clin Chim Acta, 2014, 427:42-48. (通讯作者).
14.Chunmei Guo, Shuqing Liu, Ming-Zhong Sun. Potential role of Anxa1 in cancer. Future Oncology, 2013, 9(11): 1773-1793. (通讯作者).
15.Chunmei Guo, Shuqing Liu, Frederick Greenaway, Ming-Zhong Sun. Potential role of annexin A7 in cancers. Clin Chim Acta, 2013, 423: 83-89. (通讯作者)
16.Chunmei Guo, Shuqing Liu, Ming-Zhong Sun. Sequence and bioinformatic characterization of ESTs originated from Gloydius shedaoensis shedaoensis venom gland. The Anatomical Record, 2013, 296: 807-814. (通讯作者)
17.Chunmei Guo, Shuqing Liu, Ming-Zhong Sun. Novel insight into the role of GAPDH playing in tumor. Clinical and Translational Oncology, 2013, 15(3): 167-172. (通讯作者).
18.Na Wu, Shuqing Liu, Chunmei Guo, Zhijie Hou, Ming-Zhong Sun. The role of Annexin A3 playing in cancers. Clinical and Translational Oncology, 2013,15(2):106-110. (通讯作者).
19.Chunmei Guo, Shuqing Liu, Jiasheng Wang, Ming-Zhong Sun. ACTB in cancer. Clin Chim Acta, 2013, 417: 39-44. (通讯作者).
20.Xiaohui Zhang, Shuqing Liu, Chunmei Guo, Junwei Zong, Ming-Zhong Sun. The association of annexin A2 and cancers. Clinical and Translational Oncology, 2012, 14(9): 634-640 (通讯作者).
21.Shuqing Liu, Chunmei Guo, Dachang Wu, Yixin Ren, Ming-Zhong Sun, Peng Xu. Protein indicators for HaCaT cell damage induced by UVB irradiation. J. Photochem. Photobiol. B., 2012,114: 94-101. (通讯作者).
22.Ming-Zhong Sun, Zhuzhu Guan, Shuqing Liu, Xin Zhou, Na Wang, Shujuan Shao, Dongmei Lin. Caveolin-1 interferes cell growth of lung cancer NCI-H446 cell through the interactions with phospho- ERK1/2, estrogen receptor and progestin receptor. Biomedicine & Pharmacotherapy, 2012,66(4): 242-248 (第一作者).
23.Chunmei Guo, Shuqing Liu, Yiwen Yao, Qiaoqiao Zhang, Ming-Zhong Sun. Past decade study of snake venom L-amino acid oxidase. Toxicon, 2012,60(3):302-311 (通讯作者).
24.Junwei Zong, Chunmei Guo, Shuqing Liu, Ming-Zhong Sun, Jianwu Tang. Proteomic research progress in lymphatic metastases of cancers. Clinical and Translational Oncology. 2012, 14 (1):21-30 (通讯作者).
25.Ming-Zhong Sun, Xiaoying Zhang, Yi Xin. Purification and characterization of an endo-D-arabinase produced by Cellulomonas. The Protein Journal, 2012,31(1):51-58 (第一作者).

教育背景 :
1994年9月-1999年12月，中国科学院长春应用化学研究所，无机化学，理学博士(硕博连读)，导师: 倪嘉缵院士；1990年9月-1994年7月，聊城师范学院，化学系，化学教育，理学学士。