导师姓名：黄灿华
性别：男
人气指数：136

所属院校：海南医学院
所属院系：海南省热带病重点实验室
职称：
导师类型：
招生专业：病理学与病理生理学
研究领域： 肿瘤发生和干预
研究领域： 肿瘤发生和干预 [收起]




通讯方式 :
办公电话：**
电子邮件：hcanhua@hotmail.com


个人简述 :
2000年在中国科学院获博士学位，随后在新加坡国立大学生物系从事博士后研究。2003 年8月被新加坡国立大学肿瘤研究所聘为Research Scientist。2005年9月回国任四川大学生物治疗国家重点实验室教授。国家杰出青年科学基金获得者（2012）；国家重大科学研究计划（973计划） “病毒诱导肿瘤发生的氧化还原蛋白质组研究”项目首席科学家(2013-2017)；教育部长江学者特聘教授（2013、2014）。中国生物化学与分子生物学会蛋白质组学专业委员会委员；国际学术刊物　Proteomics、 Signal Transduction and Targeted Therapy 编委委员。
回国以来以通讯作者在　Mol Cell Proteomics (5篇)、Gastroenterology、Cancer Res (封面论文)、Autophagy (3篇)、Cell Death Differ、 Oncotarget、J Cell Sci、J Infect Dis、Carcinogenesis、J Biol Chem 等学术刊物上发表SCI论文50余篇，其中30篇论文影响因子大于5.0，被引用1400余次。受邀请在　Mass Spectrom Rev、Med Res Rev、Expert Rev Proteomics (5篇) 等国际学术刊物上发表多篇关于系统生物学前沿综述；作为客座编辑出版一期　Comb Chem High Throughput Screen (2012)。受邀请在“The 2nd Proteomics Symposium on Inflammation and Cancer”(2014/05 广州)、“Asia Oceania Human Proteome Organization (AOHUPO) 8th Congress”(2013/09 重庆)、“The 18th Annual Lorne Proteomics Symposium”(2013/02 Lorne, Australia)、“CSH Asia/ICMS肿瘤微环境联合会议”(2012/11 苏州)、“Asia Oceania Human Proteome Organization (AOHUPO) 6th Congress”(2012/05 北京)、“第一届自噬生物学与疾病国际研讨会”(2015/06 北京)做大会特邀(主题)报告。


科研工作 :
1. Yuan K, Lei Y, Chen H, Chen Y, Zhang T, Li K, Xie N, Wang K, Feng X, Pu Q, Yang W, Wu Min, Xiang R, Feitelson MA, Nice EC, Wei Y, Huang C*. HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3. Cell Death Differ. (In press) (IF=8.184)
2. Zhang L, Wang K, Lei Y, Li Q, Nice EC, Huang C*. Redox Signaling: Potential Arbitrator of Autophagy and Apoptosis in Therapeutic Response. Free Radical Bio Med. (In press) (IF=5.736)
3. Liu R, Huang S, Lei Y, Zhang T, Wang K, Liu B, Nice EC, Xiang R, Xie K, Li J*, Huang C*. FGF8 promotes colorectal cancer growth and metastasis by activating YAP1. Oncotarget. 2015 Jan 206(2):935-52. (IF=6.359)
4. Lei Y, Wang K, Deng L, Chen Y, Nice EC, Huang C*. Redox Regulation of Inflammation: Old Elements, a New Story. Med Res Rev. 2015 Mar35(2):306-40. (IF=8.431)
5. Liu R, Li J, Zhang T, Zou L, Chen Y, Wang K, Lei Y, Yuan K, Li Y, Lan J, Cheng L, Xie N, Xiang R, Nice EC, Huang C*, Wei Y. Itraconazole suppresses the growth of glioblastoma through induction of autophagy: Involvement of abnormal cholesterol trafficking. Autophagy. 2014 May 1510(7) (IF=11.753)
6. Liu R, Li J, Xie K, Zhang T, Lei Y, Chen Y, Zhang L, Huang K, Wang K, Wu H, Wu M, Nice EC, Huang C*, Wei Y. FGFR4 promotes stroma-induced epithelial-to-mesenchymal transition in colorectal cancer. Cancer Res. 2013 Oct 173(19):5926-35. (IF=9.329)
7. Wen X, Wu J, Wang F, Liu B*, Huang C*, Wei Y. Deconvoluting the role of reactive oxygen species and autophagy in human diseases. Free Radic Biol Med. 2013 Dec65:402-10. (IF=5.736)
8. Liu R, Huang L, Li J, Zhou X, Zhang H, Zhang T, Lei Y, Wang K, Xie N, Zheng Y, Wang F, Nice EC, Rong L, Huang C*, Wei Y. HIV Infection in gastric epithelial cells. J Infect Dis. 2013 Oct 15208(8):1221-30. (IF=5.997)
9. Wu J, Xie N, Xie K, Zeng J, Cheng L, Lei Y, Liu Y, Song L, Dong D, Chen Y, Zeng R, Nice EC, Huang C*, Wei Y. GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer. Carcinogenesis. 2013 Dec34(12):2861-9. (IF=5.334)
10. Yuan K, Xie K, Fox J, Zeng H, Gao H, Huang C*, Wu M*. Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice. Gastroenterology. 2013 Oct145(4):853-64.e9. (IF=16.716)
11. Deng L, Lei Y, Liu R, Li J, Yuan K, Li Y, Chen Y, Liu Y, Lu Y, Edwards CK 3rd, Huang C*, Wei Y. Pyrvinium targets autophagy addiction to promote cancer cell death. Cell Death Dis. 2013 May 24:e614. (IF=5.014)
12. Wang K, Zhang T, Dong Q, Nice EC, Huang C*, Wei Y. Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis. 2013 Mar 144:e537. (IF=5.014)
13. Zhou S, Liu R, Yuan K, Yi T, Zhao X*, Huang C*, Wei Y. Proteomics analysis of tumor microenvironment: Implications of metabolic and oxidative stresses in tumorigenesis. Mass Spectrom Rev. 2013 Jul-Aug32(4):267-311. (IF=7.709)
14. Klionsky DJ, Abdalla FC...Canhua H, et al., Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr8(4):445-44. (IF=11.753)
15. Zhou S, Yi T, Liu R, Bian C, Qi X, He X, Wang K, Li J, Zhao X*, Huang C*, Wei Y. Proteomics identification of annexin A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis. Mol Cell Proteomics. 2012 Jul11(7):M112.017988. (IF=6.564)
16. Yuan K, Huang C*, Fox J, Laturnus D, Carlson E, Zhang B, Yin Q, Gao H, Wu M*. Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages. J Cell Sci. 2012 Jan 15125(Pt 2):507-15. (IF=5.432)
17. Zhou S, Li Y, Huang F, Zhang B, Yi T, Li Z, Luo H, He X, Zhong Q, Bian C, Lin X, Qi X, Liu P, Huang C, Zhao X*, Wei Y. Live-attenuated measles virus vaccine confers cell contact loss and apoptosis of ovarian cancer cells via ROS-induced silencing of E-cadherin by methylation. Cancer Lett. 2012 May 1318(1):14-25. (IF=5.621)
18. Lei Y, Huang K, Gao C, Lau QC, Pan H, Xie K, Li J, Liu R, Zhang T, Xie N, Nai HS, Wu H, Dong Q, Zhao X, Nice EC, Huang C*, Wei Y. Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells. Mol Cell Proteomics. 2011 Oct10(10):M110.005397. (IF=6.564)
19. Wang K, Liu R, Li J, Mao J, Lei Y, Wu J, Zeng J, Zhang T, Wu H, Chen L, Huang C*, Wei Y. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy. 2011 Sep7(9):966-78. (IF=11.753)
20. Li J, Liu R, Lei Y, Wang K, Lau QC, Xie N, Zhou S, Nie C, Chen L, Wei Y, Huang C*. Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. Autophagy. 2010 Aug6(6):711-24. (IF=11.753)
21. Li Z, Huang C*, Bai S, Pan X, Zhou R, Wei Y, Zhao X*. Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach. Int J Cancer. 2008 Nov 15123(10):2377-83. (IF=5.085)
22. Liu R, Li Z, Bai S, Zhang H, Tang M, Lei Y, Chen L, Liang S, Zhao YL, Wei Y, Huang C*. Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone-mediated gastric carcinogenic signaling pathway. Mol Cell Proteomics. 2009 Jan8(1):70-85. (IF=6.564)
23. Wang Z, Jiang L, Huang C*, Li Z, Chen L, Gou L, Chen P, Tong A, Tang M, Gao F, Shen J, Zhang Y, Bai J, Zhou M, Miao D, Chen Q*. Comparative proteomics approach to screening of potential diagnostic and therapeutic targets for oral squamous cell carcinoma. Mol Cell Proteomics. 2008 Sep7(9):1639-50. (IF=6.564)
24. Li Z, Zhao X*, Bai S, Wang Z, Chen L, Wei Y, Huang C*. Proteomics identification of cyclophilin a as a potential prognostic factor and therapeutic target in endometrial carcinoma. Mol Cell Proteomics. 2008 Oct7(10):1810-23. (IF=6.564)


教育背景 :
1997-2000 中国科学院武汉病毒研究所/中科院水生生物研究所联合培养 研究生/理学博士
1993-1996 中国科学院武汉病毒研究所 研究生/理学硕士
1987-1991 湖北大学生物系 本科/理学学士