导师姓名：柳晓泉
性别：男
人气指数：150

所属院校：中国药科大学
所属院系：药学院
职称：教授
导师类型：
招生专业：药学（工业药学方向）、药学（药物代谢动力学）
研究领域： 1．药动学和药效学结合模型研究2．创新药物的药代动力学研究
研究领域： 1．药动学和药效学结合模型研究2．创新药物的药代动力学研究 [收起]




通讯方式 :
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科研工作 :
近期代表性论文及成果等：1. Hua He,, Xi Li, Haidong Wang, Wenting Zhang, Huiyong Jiang,Shijun Wang, Linhua Yuan, Yao Liu, and Xiaoquan LiuEffects of Salvianolic Acid A on Plasmaand Tissue Dimethylarginine Levels in a Rat Model of Myocardial Infarction J Cardiovasc Pharmacol 2013：61：482-4882. Hua He, Shijun Wang, Xi Li, Haidong Wang, Wenting Zhang, Linhua Yuan, Xiaoquan Liu A novel metabolic balance model for describing the metabolicdisruption of and interactions between cardiovascular-relatedmarkers during acute myocardial infarction Metabolism 2013；62：1357-13663. Chen Y, Cao Y, Zhou J, Liu X Mechanism-based pharmacokinetic- pharmacodynamic modeling of bidirectional effect of danshensu on plasma homocysteine in rats. Pharm Res 2009 26(8):1863-73.4． Cao Y, Chai JG, Chen YC, Zhao J, Zhou J, Shao JP, Ma C,Liu XD,Liu XQ Beneficial effects of danshensu, an active component of silvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rat. Br J Pharmacol **(3):482-905． Wang H, Ma C, Zhou J, Liu XQ.Stereoselective analysis of tiopronin enantiomers in rat plasma using high-performance liquid chromatography-electrospray ionization mass spectrometry after chiral derivatization. Chirality 200921(5):531-8.6．Cao YG, Zhang L，Ma C, Chang BB, Chen YC, Tang YQ, Liu XD, Liu XQ Metabolism of protocatechuic acid influence fatty acid oxidation in rat heart: new anti-angina mechanism implication Biochem Pharmacol 200977(6):1096-11047． Cao YG, Chen YC，Hao K , Zhang M, Liu XQ An in vivo approach for globally estimation the drug flow between blood and tissue foe nafamostat mesilate: the main hydrolysis site determination in human. Biol Pharm Bull 200835(11): 1985-1989.8．Wang H, Chen Y, Zhou J, Ma C, Chen YC, Liu XQ. Stereoselective determination of ornidazole enantiomers in human plasma and urine samples by chiral LC: application to pharmacokinetic study Chromatographia 200867(11/12):875-8819． Cao YG, Zhang M, Yu D, Shao JP, Chen YC, Liu XQ A method for quantifying the unstable and highly polar drug nafamostat mesilate in human plasma with optimized solid-phase extraction and ESI-MS detection: more accurate evaluation for pharmacokinetic study. Anal Bioanal Chem. ** (3):1063-71.10．Hao K, Liu XQ, Wang GJ， Zhao XP Pharmacokinetics, tissue distribution and excretion of gambogic acid in rat. Eur J Drug Metab Pharmacokinet 200732(2):63-68

教育背景 :
2001年于中国药科大学药代中心获得博士学位