导师姓名：邓文生
性别：男
人气指数：374

所属院校：武汉科技大学
所属院系：生命科学与健康学院
职称：教授
导师类型：硕导/博导
招生专业：化学工程与技术、生物学


通讯方式 :
办公电话：**
电子邮件：dengwensheng@wust.edu.cn


个人简述 :
博士—中科院微生物研究所， 1996.9-2000.6硕士—中国农业大学，1993.9-1996.6学士—江西农业大学，1985.9-1989.6工作经历武汉科技大学—‘香涛学者’特聘教授（2013-2015），‘楚天学者’特聘教授（2015—至今）， 教授， 2015.1—至今英国卡迪夫大学， 生物学院—Research Associate，Lecturer , 2012.2—2013.10英国曼彻斯特大学，生命科学学院—Research Associate, 2003.5—2012.1伦敦大学，卫生与热带医学学院—Postdoctoral Fellow,2000.5—2003.5?研究兴趣我们的研究兴趣专注于与癌症发生、发展相关的基因转录调控机制以及干细胞向神经细胞、心肌细胞分化的分子机制。

科研工作 :
项目名称及下达编号项目来源起讫时间科研经费(万元)本人承担任务： BRF1在RNA聚合酶I指导的基因转录中的作用及其作用机制国家自然科学基金项目2017.01-2020.1265.00负责人细丝蛋白A在RNA聚合酶III指导的基因转录中的作用机制的研究国家自然科学基金项目2013.01-2016.1280.00负责人代表性论文 1.???????? Juan Wang#, Shasha Zhao#, Wei He, Yun Wei, Yang Zhang, Henry Pegg, Paul Shore, Stefan G.E. Roberts*, Wensheng Deng* （2017）A transcription factor ⅡA-binding site differentially regulates RNA polymerase Ⅱ–mediated transcription in a promoter context-dependent manner. Journal of Biological Chemistry (2017年5月24日， Epub ahead of print).2.???????? Juan Wang#, Yun Wei#, Shasha Zhao, Yun Zhou, Wei He, Yang Zhang, Wensheng Deng*.（2017）The analysis of viability for mammalian cells treated at different temperatures and its application in cell shipment. PLOS ONE. 12(4):e**.3.???????? Juan Wang , Shasha Zhao S, Yun Wei, Ying Zhou, Paul Shore* , Wensheng Deng*. (2016) Cytoskeletal Filamin A Differentially Modulates RNA Polymerase Ⅲ Gene Transcription in Transformed Cell Lines. Journal of Biological Chemistry. 291(48): 25239-25246.4.???????? Juan Wang, ShaSha Zhao,Ying Zhou，Yun Wei and Wensheng Deng* (2015) Establishment and validation of a non-radioactive method for in vitro transcription assay using primer extension and quantitative real time PCR. PLOS ONE, 10(8):e**.5.???????? Wensheng Deng, Cesar Lopez-Camacho, Dean Jackson& Paul Shore (2012) Filamin A is nucleolar protein that suppresses ribosomal RNA gene transcription. Proc Natl Acad Sci （USA) 109:1524-1529.6.???????? Deng W., Malecova B., Oelgerschlager T. and Roberts S.G. E. (2009) TFIIB recognition element controls the NC2-TFIIA axis in transcription regulation. Molecular and Cellular Biology 29(6):1389-400)7.???????? McRobert L., Taylor C.J., Deng W., Fivelman Q.L., Cummings R.M., Billker O. & Baker D.A. (2008) Gametogenesis in Malaria Parasites is mediated by the cGMP-Dependent Protein Kinase. PLOS Biology Vol 6(6) 1243-1252. 8.???????? Deng W. andRoberts S.G.E (2005) A core promoter element downstream of the TATA box that is recognized by TFIIB. Genes & Development 19: 2418-2423.9.???????? Deng W., Parbhu-Patel A. &. Baker D.A (2003) The role of two novel regulatory sites in the activation of? cGMP-dependent protein kinase from Plasmodium falciparum. Biochemical Journal? 374: 559-56510.???? Deng W. and Baker D.A. (2002) A novel cyclic GMP-dependent kinase is expressed in the ring stage of the Plasmodium falciparum life cycle. Molecular Microbiology. 44: 1141-1151