导师姓名：韩丽媛
性别：女
人气指数：379

所属院校：宁波大学
所属院系：医学院
职称：讲师
导师类型：
招生专业：流行病与卫生统计学


通讯方式 :
电子邮件：hanliyuan@nbu.edu.cn


个人简述 :
韩丽媛，讲师，哈尔滨医科大学医学博士，杜兰大学博士后，苏州大学博士后。浙江省预防医学会流行病学专业青年委员会委员。现主持国家自然科学基金青年项目1项、浙江省自然科学基金项目2项、教育部人文社科项目1项、浙江省教育厅项目1项、宁波市自然科学基金1项等。参与编写留学生流行病学英文版教材《预防医学、医学统计学和流行病学（英文版）》著作1部、大学本科教材《预防医学》1部等。在国内外专业期刊发表学术论文25篇，其中SCI收录23篇，关于糖尿病的研究成果以第一作者在国际著名学术期刊《Diabetologia》(SCI IF 6.973)发表，并被国际著名Elsevier 学术网站收录为中国学者发表的重要研究论文。现为Molecular Medicine Report及浙江预防医学杂志审稿专家。主要研究方向：糖尿病及高血压等慢性病的发病机制及流行病学研究。


科研工作 :
1、Liyuan Han Qunhong Wu Changyi Wang et al. Homocysteine, Ischemic Stroke, and Coronary Heart Disease in Hypertensive Patients A Population-Based, Prospective Cohort Study. Stroke.2015, DOI: 10.1161/STROKEAHA.115.009111

2、Changyi Wang, Liyuan Han*, Qunhong Wu et al. Association between homocysteine and incidence of ischemic stroke in subjects with essential hypertension: a matched case-control study. Clin Exp Hypertens, 2015,DOI: 10.3109/**.2015.**

3、Liyuan Han, Panpan Liu, Changyi Wang, Qilong Zhong, Rui Fan, Lin Wang*, Shiwei Duan* and Lina Zhang*. The interactions between alcohol consumption and DNA methylation of the ADD1 gene promoter modulate essential hypertension susceptibility in a population-based, case–control study. Hypertension Research. 2015 Jan 8. doi: 10.1038/hr.2014.172.

4、Han L,Zhang L,Xing W,Zhuo R,Lin X,Hao Y,Wu Q*,Zhao J*.The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility. J Diabetes Res.**:805801. doi: 10.1155/2014/805801. Epub 2014 Apr 28.

5、Li-Yuan Han, Kui Liu, Xia-Lu Lin, Bao-Bo Zou*, Jin-Shun Zhao*.Lack of Any Association of GST Genetic Polymorphisms with Susceptibility to Ovarian Cancer. Asian Pac J Cancer Prev. 2014 15(15):6131-6.

6、Han L,Tang L,Wang C,Chen Z,Zhang T,Chen S,Liu S,Peng X,Mai Y,Duan S*. Fat mass and obesity-associated gene rs** polymorphism is significantly associated with prediabetes and type 2 diabetes subsequent to adjustment for body mass index. Biomed Rep.2014 Sep2(5):681-686.

7、Han LY,Wu QH*,Jiao ML,Hao YH,Liang LB,Gao LJ,Legge DG,Quan H,Zhao MM,Ning N,Kang Z,Sun H. Associations between Single-nucleotide Polymorphism (+45 T>G, +276 G>T, -11377 C>G, -11391G>A) of Adiponectin Gene and the risk of Type 2 diabetes mellitus: a systematic review and meta-analysis, Diabetologia [J]. 2011,54(9): 2303-14

8、Changyi Wang , Qunhong Wu , Lina Zhang , Yanhua Hao , Rui Fan, Xiaolin Peng , Shengyuan Liu , Zhongwei Chen, Tao Zhang , Sihan Chen , Jianping Ma , Shiwei Duan , Liyuan Han*.Elevated Total Plasma Homocysteine Levels Are Associated with Type 2 Diabetes in Women with Hypertension. Asia Pacific Journal of Clinical Nutrition. 201524(4):683-91. doi: 10.6133/apjcn.2015.24.4.09.

9、ChangyiWang, Sihan Chen, Tao Zhang, Zhongwei Chen, Shengyuan Liu,Xiaolin Peng, Jianping Ma, Xiaohong Zhong, Yanqiong Yan, Linlin Tang,Yifeng Mai, Liyuan Han*, and Shiwei Duan*. Prediabetes is associated with HNF-4 alpha P2 promoter polymorphism rs**: a case-control study in Han Chinese population and an updated meta-analysis. Dis Markers. 2014. 2014: 231736

10、Yuan Li#, Qun Hong Wu*, Ming Li Jiao#, Xiao Hong Fan#, Quan Hu, Yan Hua Hao#, Ruo Hong Liu, Wei Zhang,Yu Cui, Li Yuan Han#. Gene–environment interaction between adiponectin gene polymorphisms and environmental factors on the risk of diabetic retinopathy.J Diabetes Invest J Diabetes Investig. 2015 Jan6(1):56-66.

11、Du Y,Han LY#,Li DD,Liu H,Gao YH,Sun DJ*.Associations Between XRCC1 Arg399Gln, Arg194Trp, and Arg280His Polymorphisms and Risk of Differentiated Thyroid Carcinoma: A Meta-analysis. Asian Pac J Cancer Prev.201314(9):5483-7.

12、He Y#,Han L#,Li W,Shu X,Zhao C,He Y,Bi M,Li Y*,Sun C*. Effects of the calcium-sensing receptor A986S polymorphism on serum calcium and parathyroid hormone levels in healthy individuals, Gene [J]. 2012( 491):110-1153.

13、Libo Liang, Qunhong Wu*, Lijun Gao,Yanhua Hao, Chaojie Liu, Yanguang Xie,Hong Sun, Xinglu Yan,Fabin Li,Honghai Li,Hongxia Fang,, Ning Ning,1 Yu Cui, Liyuan Han，Factors contributing to the high prevalence of multidrug-resistant tuberculosis: a study from China[J]. Thorax 2012 Jul67(7):632-8.

14、Wang CY,Chen ZW,Zhang T,Liu J,Chen SH,Liu SY,Han LY,Hui ZH,Chen YM*. Elevated plasma homocysteine level is associated with ischemic stroke in Chinese hypertensive patients. Eur J Intern Med.2014 Jul25(6):538-44. doi: 10.1016/j.ejim.2014.04.011. Epub 2014 May 11.

15、Fan X,Wu Q*,Li Y,Hao Y,Ning N,Kang Z,Cui Y,Liu R,Han L. Association of polymorphisms in the vascular endothelial growth factor gene and its serum levels with diabetic retinopathy in Chinese patients with type 2 diabetes: a cross-sectional study. Chin Med J (Engl). 2014. 127(4): 651-7.

16、Liu K,Lin X,Zhou Q,Ma T,Han L,Mao G,Chen J,Yue X,Wang H,Zhang L,Jin G,Jiang J,Zhao J*,Zou B*. The Associations between Two Vital GSTs Genetic Polymorphisms and Lung Cancer Risk in the Chinese Population: Evidence from 71 Studies. PLoS One.2014 Jul 189(7):e102372. doi: 10.1371/journal.pone.**. eCollection 2014.

17、Fan X,Wu Q*,Li Y,Hao Y,Ning N,Kang Z,Cui Y,Liu R,Han L.Association between adiponectin concentrations and diabetic retinopathy in patients with type 2 diabetes: a meta analysis. Chin Med J (Engl).**(4):765-71.

18、Li Yang, QunhongWu*, Yuan Li, Xiaohong Fan, Yanhua Hao, Hong Sun,Yu Cui, and Liyuan Han. Association of the Receptor for Advanced Glycation End Products Gene Polymorphisms and Circulating RAGE Levels with Diabetic Retinopathy in the Chinese Population. Journal of Diabetes Research. 2013. http://dx.doi.org/10.1155/2013/264579

19、Ji H,Wang Y,Liu G,Xu X,Dai D,Chen Z,Zhou D,Zhou X,Han L,Li Y,Zhuo R,Hong Q,Jiang L,Zhang X,Liu Y,Xu L,Chang L,Li J6,An P1,Duan S,Wang Q. OPRK1 promoter hypermethylation increases the risk of Alzheimer's disease. Neurosci Lett. 2015 Oct 8606:24-9. doi: 10.1016/j.neulet.2015.08.027. Epub 2015 Aug 20.

20、Liyuan Han*, Yanfen Liu*, Shiwei Duan, Benjamin Perry, Wen Li, and Yonghan He. DNA methylation and hypertension: emerging evidence and challenges . Briefings in Functional Genomics, 2016, 1–10 . doi: 10.1093/bfgp/elw014

21、Liyuan Han, Yanfen Liu, Changyi Wang, Linlin Tang , Xiaoqi Feng ,Thomas Astell-Burt, Qi wen, Donghui Duan, Nanjia Lu, Guodong Xu,Kaiyue Wang, Lu Zhang, Kaibo Gu, Sihan Chen, Jianping Ma, Tao Zhang, Dingyun You** , Shiwei Duan *. Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review. Clinical nutrition (Edinburgh, Scotland), 2016. http://dx.doi.org/10.1016/j.clnu.2016.11.011. 22、Jianping Ma#, Jufang Wang#, Yanfen Liu#, Changyi Wang#, Donghui Duan, Nanjia Lu, Kaiyue Wang, Lu Zhang, Kaibo Gu, Sihan Chen, Tao Zhang, Dingyun You,* and Liyuan Han,*. Comparisons of serum miRNA expression profiles in patients with diabetic retinopathy and type 2 diabetes mellitus. [J]. Clinics, 2017, 72(2):111.

23、Liyuan Han*, Yuanyuan Li*, Linlin Tang*, Zhongwei Chen, Tao Zhang, Sihan Chen,Shengyuan Liu, Xiaolin Peng, Yifeng Mai, Renjie Zhuo, Changyi Wang and Shiwei Duan. IGF2BP2 rs** polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study. Experimental & Therapeutic Medicine, 2016, 12(3). DOI: 10.3892/etm.2016.3554.

24、刘艳芬，陆南佳，段东辉，段世伟，韩丽媛*，麦一峰*. 表观遗传DNA甲基化与糖尿病研究进展[J]. 生命科学研究, 2016, 20(3):271-277.DOI： 10.16605/j.cnki.1007-7847.2016.03.015

25、张爱平，汪燕，韩丽媛*.同型半胱氨酸与心脑血管疾病的研究进展[J].生命科学，2015，27(7)，DOI: 10.13376/j.cbls/**
学术组织名称

级 别

所任职务

任职起止时间

浙江省流行病学青年委员会

省级

委员

2013.06—至今

浙江省预防医学会

省级

会员

2013.06—至今

宁波市预防医学会

市级

会员

2013.06—至今

宁波市全科医学学会

市级

会员

2016.06—至今
1、国家自然科学基金，**，循环miRNAs调控糖尿病性视网膜病变新生血管形成的机制研究.2015-2017，23万，在研，主持。

2、中国博士后自然科学基金面上项目，156458，Hcy代谢关键酶基因甲基化调控缺血性脑卒中的分子机制. 2015-2017，8万，在研，主持。

3、教育部人文社科，14YJC630046，全民医保评价指标体系构建及实证研究-—以浙江省为例.2015-2017，8万，在研，主持。

4、江苏省博士后基金，缺血性脑卒中的发病机制研究，2017 -2018，3万，在研，主持。

5、浙江省自然科学基金，LY17H260002，DNA甲基化调控缺血性脑卒中的发病机制研究，2017至2019，10万，在研，主持。

6、浙江省自然科学基金，LQ13H260002，循环miRNAs对2型糖尿病视网膜早期病变的预测研究.2013-2015，5万，结题。

7、宁波市自然科学基金，2014A610268，糖尿病性视网膜病变循环miRNAs差异表达及其调控新生血管的机制研究，2014-2015，5万，结题。

8、浙江省教育厅基金，Y**，血清脂联素与糖尿病性视网膜病变的相关性研究.2013-2015，1万，结题。

9、横向项目，**，宁波大学-深圳市南山区慢性病防治院合作平台。2015-2020，50万元，在研，主持。

10、横向项目，**，慢性病高危人群健康管理效果评估与研究。2016-2019，30万元，在研，主持。
专利3项

1、可用于检测2型糖尿病相关的PTPN1基因启动子区甲基化程度的试剂盒及其应用(**35).发明型专利. 2015.第一发明人

2、用于检测2型糖尿病视网膜病变的miR-3197分子标记物及其扩增引物和应用(**33).发明型专利. 2015.第一发明人

3、用于检测2型糖尿病视网膜病变的miR-2116-5p分子标记物及其扩增引物和应用(**00).发明型专利. 2015.第一发明人