导师姓名：刘昱
性别：女
人气指数：1044

所属院校：宁波大学
所属院系：医学院
职称：教授
导师类型：
招生专业：生物化学与分子生物学、流行病与卫生统计学、劳动卫生与环境卫生学
研究领域： 神经生物/精神药理
研究领域： 神经生物/精神药理 [收起]




通讯方式 :
电子邮件：liuyu@nbu.edu.cn


个人简述 :
刘昱：副教授，硕士生导师，在美国获得硕士和博士学位，并完成博士后培训。主要从事精神药理、药物研发、药效学评价。获得浙江省“钱江人才”，浙江省科协育才工程和宁波市海外高层次“3315”人才项目资助，主持了多项科研基金，包括国家、省、宁波市自然基金、教育部留学回国人员基金和瑞士开发社会国际合作项目等多项课题。作为项目核心成员，参加了国家自然科学基金重点项目、浙江省教育厅 “医学细胞和分子生物学”创新团队和宁波市科技局创新团队。共发表sci文章33篇。作为指导老师，指导学生分别获得了“挑战杯”浙江省大学生课外学术科技作品竞赛一等奖（2011）、特等奖（2013）、国家大学生课外学术科技作品竞赛特等奖（2015）、二等奖（2011）和三等奖（2013）。



科研工作 :
1. Y Liu，D Lin，B Wu，W Zhou. (2016) Ketamine abuse potential and use disorder. Brain Research Bulletin,2016,126:68-73

2. Li X, Li S, Zheng W, Pan J, Huang K, Chen R, Pan T, Liao G, Chen Z, Zhou D, Shen W, Zhou W, Liu Y (Corresponding author). Environmental Enrichment and abstinence attenuate ketamine-induced cardiac and renal toxicity (2015 Jun). Scientific Reports. 265:11611.

3. Huang X, Huang K1, Zheng W, Beveridge TJ, Yang S, Li X, Li P, Zhou W, Liu Y (Corresponding author) (2015 Feb) The effects of GSK-3β blockade on ketamine self-administration and relapse to drug-seeking behavior in rats. Drug and Alcohol Depend. 147:257-65.

4. Wu W, Liu Y, Huang X, Chen L, Zhai H (2014) Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats. Psychopharmacology. 2014 Oct 231(21):4109-18.

5. Liu Y, Li L, Zhang Y, Zhang L, Shen W, Xü H, Wang G, Lü W, Zhou W. (2013 Aug) Assessment of attitudes towards methadone maintenance treatment between heroin users at a compulsory detoxification centre and methadone maintenance clinic in Ningbo, China. Subst Abuse Treat Prev Policy. 8(1):29.

6. Shen W,Liu Y,Li L, Zhang Y,Zhou W. (2012 Oct) Negative moods correlate with craving in female methamphetamine users enrolled in compulsory detoxification.Subst Abuse Treat Prev Policy. 30 7:44.

7. Zhao C, Lou Z, Zimmer B, Yu Z, Li P, Ma B, Sun Y, Huang K, Zhou W, Liu Y (corresponding author) (2012, October) Chronic treatment with curcumin enhances methamphetamine locomotor sensitization and cue-induced reinstatement of methamphetamine self-administration. Pharmacology, Biochemistry and Behavior. 102(4):555-61.

8. Lü X, Zhao C, Zhang L, Ma B, Lou Z, Sun Y, Chen J, Wu W, Beveridge TJR, Zhou W, Liu Y (corresponding author) (2012, August) The effects of rearing condition on methamphetamine self-administration and cue-induced drug seeking. Drug and Alcohol Dependence. 124 (3) 288-298. 5

9. Liu Y, Barlette N, Li L, Zhang Y, Zhou W (2012, February) Attitudes and knowledge about naloxone and overdose prevention among detained drug users in Ningbo, China. Substance Abuse Treatment, Prevention, and Policy. 7(1):6

10.SunHQ,LiuY,LiP,ShengLX,ZhangRL,CaoYJ,DiXL,YangFD,WangF,LuoYX,LinL(2012,August)Effectsofacutecombinedserotoninanddopaminedepletiononcue-induceddrinkingintention/desireandcognitivefunctioninpatientswithalcoholdependence.DrugandAlcoholDependence.124(3):200-6.

11. Shen W, Liu Y, Li L, Zhang Y, Zhou W (2012) Negative moods correlate with craving in female methamphetamine users enrolled in compulsory detoxification. Subst Abuse Treat Prev Policy. 307: 44.

12. Liu H, Lai M, Zhou X, Zhu H, Liu Y, Sun A, Ma B, Zhang F, Zhou W. (2012, June) Galantamine attenuates the heroin seeking behaviors induced by cues after prolonged withdrawal in rats. Neuropharmacology. 62(8):2515-21.

13. Liu S, Zhu F, Lai M, Sun L, Liu Y, Zhou W (2012) Electroacupuncture suppresses discrete cue-evoked heroin-seeking and fos protein expression in the nucleus accumbens core in rats. Evid Based Complement Alternat Med. **:286404. doi: 10.1155/2012/286404.

14. Liu Y, Bao YP, Sun HQ, Beveridge TJ, Li SX, Di XL, Yang FD, Lu L (2010, August) Long-term treatment with aripiprazole on the waking and postprandial urges to smoke in Chinese heavy smokers. Journal of Clinical Psychopharmacology. 30(4):373-80.

15. Li L, Liu Y(co-first author), Zhang Y, Beveridge TJ, Zhou W (2010 Oct) Temporal changes of smoking status and motivation among Chinese heroin-dependent, methadone-maintained smokers. Addictive Behaviors. 35(10):861-5.

16. Liu Y, Liang J, Zhao C, Zhou W (2010, May) Looking for a solution for drug addiction in China: exploring the challenges and opportunities in the way of China’s new Drug Control Law. International Journal of Drug Policy. 21(3):149-54.

17. Zhao LY, Shi J, Zhang XL, Epstein DH, Zhang XY, Liu Y, Kosten TR, Lu L (2010, February) Stress Enhances Retrieval of Drug-Related Memories in Abstinent Heroin Addicts. Neuropsychopharmacology. 35(3):720-6.

18. Liu Y, Sun HQ, Bao YP, Li XY, Beveridge TJR, Di XL, Yang FD, Lin L (2009, April 1) Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers. Drug Alcohol Dependence. 101(1-2):42-52. 12

19. Morgan D, Liu Y (co-first author), Olson EB and Roberts DCS (2009, January) Cocaine self-administration on a hold-down schedule of reinforcement. Psychopharmacology. 201(4):601-9.

20. Lu L, Liu Y, Zhu W, Shi J, Liu Y, Ling W, Kosten TR. (2009)Traditional medicine in the treatment of drug addiction. American Journal of Drug Alcohol Abuse. 35(1):1-11.

21. Yu LL, Wang XY, Zhao M, Liu Y, Li YQ, Li FQ, Wang X, Xue YX, Lu L (2009, June) Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice. Psychopharmacology. 204(2):203-11.

22. Sun HQ, Guo S, Chen DF, Jiang ZN, Liu Y, Di XL, Yang FD, Zhang XY, Kosten TR, Lu L. (2009) Family support and employment as predictors of smoking cessation success: a randomized, double-blind, placebo-controlled trial of nicotine sublingual tablets in Chinese smokers. American Journal of Drug Alcohol Abuse. 35(3):183-8.

23. Ren ZY, Zhang XL, Liu Y, Zhao LY, Shi J, Bao Y, Zhang XY, Kosten TR, Lu L (2009, January) Diurnal variation in cue-induced responses among protracted abstinent heroin users. Pharmacology Biochemistry and Behavior. 91(3):468-72.

24. Liu Y, Le Foll B, Liu Y, Wang X, Lu L (2008, December) Conditioned place preference induced by licit drugs: establishment, extinction, and reinstatement. The Scientific World Journal. 8:1228-45.

25. Li F, Qing F, Liu Y, Zhao M, Li D, Wang J, Lu L (2008, July) Cannabinoid CB(1) receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats. European Journal of Pharmacology. 589(1-3):122-6.

26. Zhai H, Wu P, Chen S, Cui Y, Li F, Liu Y and Lu L (2008, May) Effects of scopolamine and ketamine on reconsolidation of morphine conditioned place preference in rats. Behavioural Pharmacology. 19: 211-216.

27. Zhai H, Wu P, Xu C, Liu Y, Lu L (2008, September) Blockade of cue- and drug-induced reinstatement of morphine-induced conditioned place preference with intermittent sucrose intake. Pharmacology, Biochemistry and Behavior. 90(3):404-8.

28. Liu Y, Morgan D, Roberts DCS (2007, December) Cross-sensitization of the reinforcing effects of cocaine and amphetamine. Psychopharmacology. 195:369–375. 25

29. Roberts DCS, Morgan D, Liu Y (2007, November) How to make a rat addicted to cocaine. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 31(8):1614-24.

30. Morgan, Liu Y, Roberts DCS (2006, January) Rapid and persistent sensitization of the reinforcing effects of cocaine. Neuropsychopharmacology. 31(1):121-8.

31. Liu Y, Roberts DCS, Morgan D (2005, July) Sensitization of the reinforcing effects of cocaine: effects of dose and intravenous injection speed. European Journal of Neuroscience. 22(1):195-200. 68

32. Liu Y, Roberts DCS, Morgan D (2005, May) Effects of extended-access self-administration conditions and deprivation on breakpoints maintained by cocaine in rats. Psychopharmacology (Berl). 179(3):644-51.58

33. Smith MA, Yancey DL, Morgan D, Liu Y, Froestl W, Roberts DC (2004, April) Effects of positive allosteric modulators of the GABA(B) receptor on cocaine self-administration in rats. Psychopharmacology (Berl). 173(1-2):105-11.
中国药物滥用防治协会理事

浙江省毒理学会理事

国际禁毒政策年会组委会成员

1. “中枢血管紧张素II在甲基苯丙胺成瘾和神经毒性中的作用”（**），国家自然科学基金面上项目，2017.01-2020.12，项目负责人

2. “中枢血管紧张素II在甲基苯丙胺成瘾中的作用机制”（2015A610188），宁波市自然科学基金，2015.01-2017.12)，项目负责人。

3. “增强认知功能药物干预海洛因复吸的药物发现和作用机制”(U**)，国家自然科学基金重点项目，2012.01至2015.12，排名3/10。

4. “青春期环境干预成年期甲基苯丙胺自身给药动机敏化和多巴胺机制”（**）,国家自然科学基金青年科学基金项目，2011.01至2013.12，项目负责人。

5. “尼古丁和海洛因奖赏和动机协同增强与共患成瘾的易感性”（2010A610039），宁波市自然科学基金，2010.01到2012.12，项目负责人。

6. “青春期环境干预对成年期甲基苯丙胺依赖易感性和动机的作用及脑区功能影像学评价” （Y**），浙江省自然科学基金，2010.01至2012.12，项目负责人。

7. “从共患精神疾病信号通路研究甲基苯丙胺（冰毒）成瘾机制”，浙江省人力资源和社会保障厅“钱江人才”，2010.01至2012.12，项目负责人。

8. “宁波市自愿戒毒医院和美沙酮门诊分发纳络酮”(**)，瑞士开放社会研究院基金会（降低危害），2009.12至2010.11，项目负责人。

9. “尼古丁预暴露对海洛因给药动机的影响”，宁波大学人才工程项目， 2009.11至2011.10，项目负责人。

10. “人参和海洛因成瘾动机”，教育部留学回国人员基金，项目负责人。

11. “药物依赖及共患精神疾病防治创新团队”(2009B21002)，宁波市科技局，2010.01至2014.12，团队核心成员。

12. 浙江省高等学校“医学细胞和分子生物学”创新团队(T200907)，浙江省教育厅，2010.01至2012.12，主要参加人。
2015 第十四届“挑战杯”全国大学生课外学术科技作品竞赛特等奖，“丰富环境”戒毒-劳教后时代强制隔离戒毒模式的社会化新探索，指导教师，1/3

2015浙江省第十四届大学生“挑战杯“课外学术科技作品竞赛一等奖，“丰富环境”戒毒-劳教后时代强制隔离戒毒模式的社会化新探索，指导教师，1/2

2013 第十三届“挑战杯”全国大学生课外学术科技作品竞赛三等奖，指导教师，1/3

2013 浙江省第十三届大学生“挑战杯“课外学术科技作品竞赛特等奖，” 药物或青春期环境对甲基苯丙胺奖赏动机和复吸的干预作用”, 指导教师，1/2

2011 第十二届“挑战杯”全国大学生课外学术科技作品竞赛二等奖，指导教师

2011 浙江省第十二届大学生“挑战杯“课外学术科技作品竞赛一等奖，指导教师