导师姓名：杜志游
性别：男
人气指数：505

所属院校：浙江理工大学
所属院系：生命科学学院
职称：副教授
导师类型：
招生专业：生物学、生态学
研究领域： 1.病毒分子特性研究2.病毒与寄主的分子互作3.病毒-植物-昆虫介体的三者互作4.抗病毒新... [展开]


研究领域： 1.病毒分子特性研究2.病毒与寄主的分子互作3.病毒-植物-昆虫介体的三者互作4.抗病毒新技 [收起]




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个人简述 :
主要学习工作经历

1.2009.10-2011.09剑桥大学玛丽居里研究员

2.2007.04-浙江理工大学副教授

3. 2001.09-2006.09浙江大学 微生物学博士

4. 1997.09-2001.06温州师范学院 生物科学本科

主要学术及社会兼职

1.浙江省政府应急管理专家

2. American Society for Virology, Associate member

3. Advance of International plant virus, Associate member

4.生命科学学院青年教师联谊会副理事长

荣誉

1.浙江省151人才第三层次

2.浙江理工大学首批521中青年拔尖人才


科研工作 :
科研教学项目

1."CMV 1a复制酶组分调控病毒亚基因组RNA4A合成的分子机制"，国家自然科学基金 30万，2014.10-2016.12.(负责人)

2.“卫星RNA和协生病毒与CMV的互作对CMV诱导拟南芥抗蚜虫反应的影响及其途径”，国家自然科学基金 64万，2012.01-2015.12（负责人）

3.“Subversion of Insect Resistance: A novel Role for a Plant Viral Silencing Suppressor”，European Commission—Marie Curie International Incoming Fellowship，160万，2009.10- 2011.09（负责人）

4.“CMV 2b蛋白致病关键氨基酸在RNA沉默通路中的作用方式和靶位”，国家自然科学基金 20万，2009.01-2011.12（负责人）

5.“外源AGO1蛋白特定片段对CMV 2b蛋白抗RNA沉默活性的干扰研究”,浙江省自然科学基金 8万，2009.1- 2010.12（负责人）

6.“蜂源性降血压功能肽高效表达基因的筛选及优化”，国家高技术发展研究计划（863计划）50万，2008.1- 2010.12（副组长，负责子课题）

7.“植物病毒的快速检测与新病毒的基因组研究”，国家自然科学基金，2006.1- 2008.12, 8万（参与，3/7）

8.“黄瓜花叶病毒2b蛋白致病性对病毒适应性的影响”，浙江理工大学博士科研启动基金 3万，2007.01-2008.12（负责人）

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专著论文

1.Du Z*, Chen A, Chen W, Liao Q, Zhang H, Bao Y, Roossinck MJ, Carr JP. Nuclear-cytoplasmicpartitioning of the Cucumber mosaic vius 2b protein determines the balance between its roles as a virulence determinant and RNA silencing sppressor. Journal of Virology, 2014，88(10): 5228-5241.Top Journal

2.Du Z*, Chen A, Chen W, Westwood J, Baulcombe DC, Carr JP*. Using viral vector to reeal therole of microRNA159 in disease symptom induction by a severe strain of Cucumber mosaic virus. Plant Physiology, 2014, 164:1378-1388.Top Journal

3. Westwood JH, Groen SC,Du Z, et al. A trio of viral proteins tunes Aphid-plant interactions in Arabidopsis thaliana. PLoS One 8(12):e83066.

4. Xu A, Zhao Z, Chen W, Liao Q, Chen J, Carr JP,Du Z*.Self-interaction of the cucumber mosaic virus 2b protein plays a vital role in suppression of RNA silencing and induction of viral symptoms. Molecular Plant Pathology.2013. 14(8):803-812

5. Li C,Du Z, Chen J.Structural and functional elucidation of AGO proteins. Chinese Journal of Biochemistry and Molecular Biology, 2009, 25(11): 969-976.

6. Li L, Tian Q,Du Z, Duns GJ, Chen J. A novel double-stranded RNA virus detected in Primula malacoides is a a plant-isolated partitivirus closely related to partitivirus infecting fungal species.Archive Virology, 2009, 164(4): 565-572.

7.Du Z, Chen F, Zhao Z, Liao Q, Palukaitis P, Chen J. The 2b protein and the C-terminus of the2aprotein of cucumber mosaic virus subgroup I strains both play a role in viral RNA accumulation and induction of symptoms.Virology2008, 380: 363-370.

8. Liao Q-S,Du Z-Y, Zhang H-R, Wu P, Zhu L-P, Chen J-S.Construction of infectious clone for cucumber mosaic virus pepper isolate.Scientia Agricultura Sinica2008, 41(7): 1975-1982. (In Chinese)

9.Du Z-Y, Chen F-F, Liao Q-S, Zhang H-R, Chen Y-F, Chen J-S.The 2b ORFs encoded by subgroup IB strains of Cucumber mosaic virus induce different virulence on Nicotiana species.Journal of General Virology2007, 88: 2596-2694.

10.Du Z, Jin B, Liu W, Chen L, Chen J. Highly sensitive fluorescent-labeled probes and glass slide hybridization for the detection of plant RNA viruses and a viroid.Acta Biochimica et Biophysica Sinica2007, 39(5): 326-334.

11. Chen Y, Chen J, Zhang H, Tang X,Du Z. Molecular evidence and sequence analysis of a natural reassortant between Cucumber mosaic virus subgroup IA and II strains.Virus Genes2007, 35: 405-413.

12. Liao Q, Zhu L,Du Z, Zeng R, Peng J, Chen J. Satellite RNA-mediated reduction of cucumber mosaic virus genomic RNAs accumulation in Nicotiana tabacum.Acta Biochimica et Biophysica Sinica2007, 39(3):217-23.

13. Chen F-F,Du Z-Y, Liu X, Xie L, Chen J-S.Effect of Cucumber mosaic virus-encoded 2b protein on Photosynthesis and chloroplast structure of the host plant.Progress in Biochemistry and Biophysics2007, 34(8): 889-896. (In Chinese)

14. Liao Q-S,Du Z-Y, Zhang H-R, Zhu L-P., Wu P, Chen J-S.Necrosis pathotype induced on Nicotiana glutinosa by infection of CMV-Cb7 related to RNA2.Progress in Biochemistry and Biophysics2007, 34(8): 824-829. (In Chinese)

15. Lang Q-L, Chen J-S, Fu T-Z,Du Z-Y.Occurrence and molecular detection of Potato virus S (PVS) inZhejiangprovince.Acta Phytopathology Sinica2007, 32(2): 217-220. (In Chinese)

16.Du Z, Chen J, Hiruki C. Optimization and application of a multiplex RT-PCR for simultaneous detection of five potato viruses using 18S rRNA as an internal control.Plant Disease2006, 90(2): 185-189.

17. Feng J, Chen S, Tang X, Ding X,Du Z, Chen J. Quantitative determination of cucumber mosaic virus genome RNAs in virions by real-time reverse transcription-polymerase chain reaction.Acta Biochimica et Biophysica Sinica2006, 38(10):669-676.

18. Gu Y,Du Z-Y, Lang Q-L, Chen J-S, He N-Y.Detection of Potato Spindle Tuber Viroid Using RNA Hybridized Chips.Chemical Research in Chinese Universities2006, 27(11):2106-2109. (In Chinese)

19.Du Z-Y, Chen J-S. Identification and grouping study of Potato virus X Hunan isolate.Virologica Sinica2003, 18(2):119-123. (In Chinese)

20. Dong X-J*,Du Z-Y, Chen Z. Decolorization of Direct Black 22 by Aspergillus ficuum.Journal of Environmental Sciences2001, 12(4): 472-475.
1. 已指导4名研究生获得硕士学位，其中1名获得校优秀硕士学位论文，其中1名获得国家奖学金和校一等奖学金；

2. 指导本科生获得浙江省新苗人才计划项目2项：

黄瓜花叶病毒2b蛋白的自身互作研究，负责人：陈影（2011级生物制药2班）

黄瓜花叶病毒2b蛋白的核仁定位研究，负责人：屠逸飞（2012级生物技术2班）
你只要有一颗热爱科研的心，你就有可能成为我们课题组的一份子，期待你的加盟！