导师姓名：丁凡舒
性别：女
人气指数：538

所属院校：大连理工大学
所属院系：
职称：
导师类型：硕导
招生专业：


通讯方式 :
电子邮件：dingfs@dlut.edu.cn


个人简述 :
窦同意，男，1987年1月出生，山东济宁人。

主要学历及工作经历:
2005.09—2009.07天津大学制药工程工学学士
2009.09—2016.01中科院大连化物所生物化工工学博士
2015.03—2015.06芬兰赫尔辛基大学分子药理博士交流生
2015.03—2015.06大连理工大学生命与医药学院讲师

主要研究领域：
1.生物大数据分析与数据挖掘（生物信息学）；
2.蛋白质结构功能关系研究（生物化学与分子生物学）。

承担项目：
1.大连理工大学基本科研业务费DUT16RC(3)016
Xyl_S酶的催化机理及其关键催化结构域的鉴定2016.4-2017.12
2.国家自然科学基金-青年基金24万
一种新型去糖基酶的催化机理及其关键催化结构域的鉴定**7.1-2019.12

代表性论文：
[1]TongyiDou,HongweiLuan,GuangboGe,MingmingDong,HanfaZou,YuqiHe,PanCui,JiayueWang,DachengHao,ShilinYang,LingYang*."Functionalandstructuralpropertiesofanovelcellulosome-likemultienzymecomplex:efficientglycosidehydrolysisofwater-insoluble7-xylosyl-10-deacetylpaclitaxel."ScientificReports,5,13768.（SCI,IF:5.578）
[2]TongyiDou,HongweiLuan,XingbaoLiu,ShiyangLi,XunfuDuandLingYang*."Enzymatichydrolysisof7-xylosyltaxanesbyanextracellularxylosidasefromCellulosimicrobiumcellulans."BiotechnologyLetters,2015,37(9):1905-1910.（SCI,IF:1.591）
[3]ZiruDai,GuangboGe,LeiFeng,JingNing,LianghaiHu,QiangJin,DandanWang,XiaLv,TongyiDou,JingnanCui,LingYang*."Ahighlyselectiveratiometrictwo-photonfluorescentprobeforhumancytochromeP4501A."JournaloftheAmericanChemicalSociety,2015,137(45):14488-95.（SCI,IF:12.113）
[4]Xing-KaiQian,PingWang,Yang-LiuXia,TongyiDou,QiangJin,Dan-DanWang,Da-ChengHao,Xiao-LinBi,Guang-BoGe,LingYang,Ahighlyselectivefluorescentprobeforsensingactivitiesofcatechol-O-methyltransferaseincomplexbiologicalsamples.SensorsandActuatorsB:Chemical,2016,231:615–623
[5]钱星凯，夏杨柳，窦同意，侯洁，马红，葛广波，秘晓林，杨凌*.儿茶酚-氧位-甲基转移酶与疾病的关系,《药学学报》，2016,51(4):543-551.（综合影响因子1.201，复合影响因子1.684，主办方：中国药学会）
[6]PanCui,TongyiDou(并列第一),GuangboGe.EfficientenzymaticpreparationofEsculentosideBfollowingconditionoptimizationbyresponsesurfacemethodology.JournalofMolecularCatalysisB:Enzymatic,Accepted.（SCI,IF:2.128）
[7]PanCui,TongyiDou(并列第一),GuangboGe.Highlyselectiveandefficientbiotransformationoflinarintoproducetilianinbynaringinase.BiotechnologyLetters,2016,38:1367–1373.（SCI,IF:1.591）
[8]YangliuXia,XiaLv,GuiyuanHe,TongyiDou,Guang-BoGe,LingYang.InvitrocharacterizationoftheglucuronidationpathwaysofD-luciferinmediatedbyhumanUDP-glucuronosyltransferases.DrugMetabolismandPharmacokinetics,2017,32(1):S77
[9]WeiLei,Dan-DanWang,TongyiDou,JieHou,LiangFeng,HengYin,QunLuo,JieSun,Guang-BoGe,LingYang.Assessmentoftheinhibitoryeffectsofpyrethroidsagainsthumancarboxylesterases.ToxicologyandAppliedPharmacology,2017,321:48–56
[10]Zi-MiaoWeng,PingWang,Guang-BoGe,Zi-RuDai,Da-ChangWu,Li-WeiZou,TongyiDou,JieHou,Tong-YanZhang,LingYang.Structure-activityrelationshipsofflavonoidsasnaturalinhibitorsagainstE.coliβ-glucuronidase.FoodandChemicalToxicology,Availableonline24March2017,https://doi.org/10.1016/j.fct.2017.03.042
[11]Jing-JingWu,Yun-FengCao,LiangFeng,Yu-QiHe,JamesY.Hong,TongyiDou,PingWang,Da-ChengHao,Guang-BoGe,andLingYang.ANaturallyOccurringIsoform-SpecificProbeforHighlySelectiveandSensitiveDetectionofHumanCytochromeP4503A5,J.Med.Chem.,2017,60(9):3804–3813
[12]PingWang,Yang-LiuXia,Li-WeiZou,Xing-KaiQian,TongyiDou,QiangJin,Shi-YangLi,YangYu,Dan-DanWang,QunLuo,GuangboGe,LingYang.AnOptimizedTwo-PhotonFluorescentProbeforBiologicalSensingandImagingofCatechol-O-Methyltransferase.Chemistry,2017,23(45):10800-10807.
[13]Li-WeiZou,TongyiDou(并列第一),PingWang,WeiLei,Zi-MiaoWeng,JieHou,Dan-DanWang,Yi-MingFan,Wei-DongZhang,Guang-BoGe,LingYang,Structure-activityrelationshipsofpentacyclictriterpenoidsaspotentandselectiveinhibitorsagainsthumancarboxylesterase1,FrontiersinPharmacology,2017,8:435.

科研工作 :
主要研究领域：
1.生物大数据分析与数据挖掘（生物信息学）；
2.蛋白质结构功能关系研究（生物化学与分子生物学）。

承担项目：
1.大连理工大学基本科研业务费DUT16RC(3)016
Xyl_S酶的催化机理及其关键催化结构域的鉴定2016.4-2017.12
2.国家自然科学基金-青年基金24万
一种新型去糖基酶的催化机理及其关键催化结构域的鉴定**7.1-2019.12

代表性论文：
[1]TongyiDou,HongweiLuan,GuangboGe,MingmingDong,HanfaZou,YuqiHe,PanCui,JiayueWang,DachengHao,ShilinYang,LingYang*."Functionalandstructuralpropertiesofanovelcellulosome-likemultienzymecomplex:efficientglycosidehydrolysisofwater-insoluble7-xylosyl-10-deacetylpaclitaxel."ScientificReports,5,13768.（SCI,IF:5.578）
[2]TongyiDou,HongweiLuan,XingbaoLiu,ShiyangLi,XunfuDuandLingYang*."Enzymatichydrolysisof7-xylosyltaxanesbyanextracellularxylosidasefromCellulosimicrobiumcellulans."BiotechnologyLetters,2015,37(9):1905-1910.（SCI,IF:1.591）
[3]ZiruDai,GuangboGe,LeiFeng,JingNing,LianghaiHu,QiangJin,DandanWang,XiaLv,TongyiDou,JingnanCui,LingYang*."Ahighlyselectiveratiometrictwo-photonfluorescentprobeforhumancytochromeP4501A."JournaloftheAmericanChemicalSociety,2015,137(45):14488-95.（SCI,IF:12.113）
[4]Xing-KaiQian,PingWang,Yang-LiuXia,TongyiDou,QiangJin,Dan-DanWang,Da-ChengHao,Xiao-LinBi,Guang-BoGe,LingYang,Ahighlyselectivefluorescentprobeforsensingactivitiesofcatechol-O-methyltransferaseincomplexbiologicalsamples.SensorsandActuatorsB:Chemical,2016,231:615–623
[5]钱星凯，夏杨柳，窦同意，侯洁，马红，葛广波，秘晓林，杨凌*.儿茶酚-氧位-甲基转移酶与疾病的关系,《药学学报》，2016,51(4):543-551.（综合影响因子1.201，复合影响因子1.684，主办方：中国药学会）
[6]PanCui,TongyiDou(并列第一),GuangboGe.EfficientenzymaticpreparationofEsculentosideBfollowingconditionoptimizationbyresponsesurfacemethodology.JournalofMolecularCatalysisB:Enzymatic,Accepted.（SCI,IF:2.128）
[7]PanCui,TongyiDou(并列第一),GuangboGe.Highlyselectiveandefficientbiotransformationoflinarintoproducetilianinbynaringinase.BiotechnologyLetters,2016,38:1367–1373.（SCI,IF:1.591）
[8]YangliuXia,XiaLv,GuiyuanHe,TongyiDou,Guang-BoGe,LingYang.InvitrocharacterizationoftheglucuronidationpathwaysofD-luciferinmediatedbyhumanUDP-glucuronosyltransferases.DrugMetabolismandPharmacokinetics,2017,32(1):S77
[9]WeiLei,Dan-DanWang,TongyiDou,JieHou,LiangFeng,HengYin,QunLuo,JieSun,Guang-BoGe,LingYang.Assessmentoftheinhibitoryeffectsofpyrethroidsagainsthumancarboxylesterases.ToxicologyandAppliedPharmacology,2017,321:48–56
[10]Zi-MiaoWeng,PingWang,Guang-BoGe,Zi-RuDai,Da-ChangWu,Li-WeiZou,TongyiDou,JieHou,Tong-YanZhang,LingYang.Structure-activityrelationshipsofflavonoidsasnaturalinhibitorsagainstE.coliβ-glucuronidase.FoodandChemicalToxicology,Availableonline24March2017,https://doi.org/10.1016/j.fct.2017.03.042
[11]Jing-JingWu,Yun-FengCao,LiangFeng,Yu-QiHe,JamesY.Hong,TongyiDou,PingWang,Da-ChengHao,Guang-BoGe,andLingYang.ANaturallyOccurringIsoform-SpecificProbeforHighlySelectiveandSensitiveDetectionofHumanCytochromeP4503A5,J.Med.Chem.,2017,60(9):3804–3813
[12]PingWang,Yang-LiuXia,Li-WeiZou,Xing-KaiQian,TongyiDou,QiangJin,Shi-YangLi,YangYu,Dan-DanWang,QunLuo,GuangboGe,LingYang.AnOptimizedTwo-PhotonFluorescentProbeforBiologicalSensingandImagingofCatechol-O-Methyltransferase.Chemistry,2017,23(45):10800-10807.
[13]Li-WeiZou,TongyiDou(并列第一),PingWang,WeiLei,Zi-MiaoWeng,JieHou,Dan-DanWang,Yi-MingFan,Wei-DongZhang,Guang-BoGe,LingYang,Structure-activityrelationshipsofpentacyclictriterpenoidsaspotentandselectiveinhibitorsagainsthumancarboxylesterase1,FrontiersinPharmacology,2017,8:435.

教育背景 :
2009.9--2014.12
大连理工大学 物理化学 博士