导师姓名：陈海敏
性别：女
人气指数：869

所属院校：宁波大学
所属院系：海洋学院
职称：研究员
导师类型：
招生专业：海洋生物学、水产养殖、食品工程、渔业发展
研究领域： 海洋生物生理生化、药理（博士）
研究领域： 海洋生物生理生化、药理（博士） [收起]




通讯方式 :
办公电话：**
电子邮件：chenhaimin@nbu.edu.cn


个人简述 :
2017.7-2017.9 University of California, San Diego,Scripps Institution of Oceanography，访问学者

2001.9-2004.8 中国科学院海洋研究所，博士

2004.8-至今 宁波大学

获奖：

1. “红藻糖生物活性研究及其产品开发”获2008年度国家海洋创新成果奖二等奖；

2. “基于生物活性的红藻膳食纤维和红藻糖的创新开发及其应用”获2009年度高等学校科学研究优秀成果奖科学技术进步奖二等奖；

3. “生物活性海洋红藻糖胶的创新研制和功能性产品开发”获2010年度浙江省科技进步奖二等奖。

4. “基于活性的红藻膳食纤维及其深加工寡糖的产品技术研发”获2008年度宁波市科技进步奖二等奖；

5. 2010年宁波市青年科技奖

6. 151人才工程第二层次

主要研究方向：

从事海洋药物、活性物质、海洋生物资源利用、藻类生理等方面的研究工作。主要的研究方向为：

海洋活性天然化合物的药理学研究（抗肿瘤、抗炎等）。

海藻的深度利用研究（藻类寡糖、多糖、蛋白、肽等的结构、药用保健和化妆品产业化开发）

藻类基因组、转基因及海藻免疫防御分子机制的研究


科研工作 :


1．Wu Wei, Zhen Zhanghe, Niu Tingting, Zhu Xiaojuan, Gao Yuli, Yan Jiangyan, Chen Yu, Yan Xiaojun, Chen Haimin. (2017). κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice. Mediators of inflammation 2017, 2017: 16. (Corresponding author).

2. Tu Shisheng, Yang Rui, Xu Xia, Chen Juanjuan, Luo Qijun, Zhu Zhujun, Chen Haimin, Yan Xiaojun. Flg22-triggered oxylipin production in Pyropia haitanensis. Phycological Research 2017, 65: 86-93. (Corresponding author).

3. Wu Wei, Wang Feng, Gao Xin, Niu Tingting, Zhu Xiaojuan, Yan Xiaojun, Chen Haimin. Synergistic effect of κ-carrageenan on oxazolone-induced inflammation in BALB/c mice.BMC gastroenterology2016, 16: 1. (Corresponding author).

4. Wu Wei, Wang Feng, Gao Xin, Niu Tingting, Zhen Zhanghe, Chen Haimin, Yan Xiaojun. Enhanced effect of κ-carrageenan on TNBS-induced inflammation in mice. International immunopharmacology 2016, 39: 218-228. (Corresponding author).

5．Chen Haimin, Jian Qiuli, Luo Qijun, Zhu Zhujun, Yang Rui, Yan Xiaojun. Application of oligoagars as elicitors for field aquaculture of Pyropia haitanensis.Journal of Applied Phycology 2015, 28: 1783-1791.

6．Niu Tingting, Zhang Dongsheng, Chen Haimin, Yan Xiaojun. Modulation of the binding of basic fibroblast growth factor and heparanase activity by purified λ-carrageenan oligosaccharides.Carbohydrate polymers 2015, 12: 76-84. (Corresponding author).

7．Lai Xiaojun, Yang Rui, Luo Qijun, Chen Juanjuan, Chen Haimin, Yan Xiaojun. Glycerol-3-phosphate metabolism plays a role in stress response in the red alga Pyropia haitanensis.Journal of Phycology2015, 51: 321-331. (Corresponding author).

8．Chen Haimin, Zhu Zhujun, Chen JuanJuan, Yang Rui, Luo Qijun, Xu Jilin, He Shan, Yan XiaoJun. A multifunctional lipoxygenase from Pyropia haitanensis-The cloned and functioned complex eukaryotic algae oxylipin pathway enzyme.Algal Research2015, 12: 316-327.

9．Zhu Zhujun, Qian Feijian, Yang Rui, Chen Juanjuan, Luo Qijun, Chen Haimin, Yan Xiaojun. A lipoxygenase from red alga Pyropia haitanensis, a unique enzyme catalyzing the free radical reactions of polyunsaturated fatty acids with triple ethylenic bonds.PloS one2015, 10: e**. (Corresponding author).

10．Chen Haimin, Wang Feng, Mao Haihua, Yan Xiaojun. Degraded λ-carrageenan activates NF-κB and AP-1 pathways in macrophages and enhances LPS-induced TNF-α secretion through AP-1.Biochimica et Biophysica Acta (BBA)-General Subjects2014, 18: 2162-2170.

11．Luo Qijun, Zhu Zhenggang, Zhu Zhujun, Yang Rui, Qian Feijian, Chen Haimin, Yan Xiaojun. Different responses to heat shock stress revealed heteromorphic adaptation strategy of Pyropia haitanensis (Bangiales, Rhodophyta).PloS one2014, 9: e94354. (Corresponding author).

12．Luo Qijun, Zhu Zhenggang, Zhu Zhujun, Yang Rui, Qian Feijian, Chen Haimin, Yan Xiaojun. Different responses to heat shock stress revealed heteromorphic adaptation strategy of Pyropia haitanensis (Bangiales, Rhodophyta).PloS one9, 4 (2014): e94354. (Corresponding author).

13．Chen Haimin, Yan Xiaojun, Wang Feng, Xu Weifeng, Zhang Lu. Assessment of the oxidative cellular toxicity of a κ-carrageenan oxidative degradation product towards Caco-2 cells.Food research international2010, 43: 2390-2401.

14. Chen Haimin, Yan Xiaojun, Lin Jing, Wang Feng, Xu Weifeng. Depolymerized products of λ-carrageenan as a potent angiogenesis inhibitor. Journal of Agricultural and Food Chemistry, 2007, 55: 6910-6917.

15. Chen Haimin, Yan Xiaojun. Antioxidant activities of agaro-oligosaccharides with different degree of polymerization in cell based system. Biochimica et Biophysica Acta. 2005, 1722: 103-111.

16. Chen Haimin, Zheng Li, Lin Wei, Yan XiaoJun. Product monitoring and quantitation of oligosaccharides composition in agar hydrolysates by precolumn labeling HPLC. Talanta,2004, 64,773-777.
国家科技部星火重大项目： 坛紫菜产业链升级关键技术集成与示范 (No. 2013GA701001)国家自然科学基金: 卡拉胶协同内毒素引起肠道炎性损伤的分子机制研究 (No. **).

国家自然科学基金“卡拉胶非安全性致炎因素及其作用方式的分子机制研究”, 2008.

浙江省自然科学基金“抗血管新生作用的λ-卡拉胶寡糖的酶法制备和构效研究”, 2010.
发明专利：

1. 一种红藻寡糖的制备方法. ZL**3.8

2. 一种λ－卡拉胶寡糖在制备血管增生的抑制剂的应用. ZL**4.2

3. 一种琼胶低聚糖在化妆品中的应用.ZL**4.7

4. 一种紫菜营养粉的加工方法. ZL**8.1

5. 一种紫菜酱的加工方法. ZL**9.6

6. 一种琼胶原藻生物肥及其制备方法. ZL **8.9

7. 琼胶寡糖在紫菜免疫增强剂中的应用及其应用方法. ZL**4.2

8. 一种促进坛紫菜壳孢子附着萌发的方法. ZL**3.X

9. 一种琼胶原藻生物肥及其制备方法. ZL**8.9