导师姓名：姚伟岸
性别：男
人气指数：562

所属院校：大连理工大学
所属院系：工程力学系
职称：教授
导师类型：硕导/博导
招生专业：固体力学、计算力学


通讯方式 :
电子邮件：ywa@dlut.edu.cn


个人简述 :
叶智识博士特聘研究员

大连理工大学-化工与环境生命学部-张大煜学院

联系邮箱；yzhsh1984@dlut.edu.cn


2017年9月-至今：大连理工大学，化工与环境生命学部-张大煜学院

2013年8月-2017年8月：美国普渡大学-博士后，导师：代明骥教授

2010年9月-2013年7月：中科院大连化学物理研究所-博士，导师：周永贵研究员

2007年9月-2010年7月：温州大学-硕士，导师：成江教授

2003年9月-2007年7月：温州大学-本科

从事过渡金属催化和有机合成研究。在过渡金属催化的有机合成方法学、不对称催化及杂环合成等领域开展了多项创新性研究，取得了多项创新成果。在Chem.Soc.Rev.,Angew.Chem.Int.Ed.，J.Am.Chem.Soc.,Org.Lett.等国际权威期刊上发表文章33篇，总引用次数1121次，H-因子为20(截止2017年10月)。获得辽宁省自然科学一等奖（第四完成人）、中国科学院院长优秀奖和浙江省优秀硕士毕业论文。


代表论文：

1.Zhi-ShiYe,Ran-NingGuo,Xian-FengCai,Mu-WangChen,LeiShi,andYong-GuiZhou.*EnantioselectiveIridium-CatalyzedHydrogenationof1-and3-SubstitutedIsoquinoliniumSalts.Angew.Chem.Int.Ed.2013,52,3685-3689.
2.Zhi-ShiYe,Mu-WangChen,Qing-AnChen,LeiShi,YingDuan,andYong-GuiZhou.*Ir-CatalyzedAsymmetricHydrogenationofPyridiniumSalts.Angew.Chem.Int.Ed.2012,51,10181-10184.
3.ZhishiYe,GuangleiLv,WenhuiWang,ManliZhang,andJiangCheng.*Rhodium-CatalyzedCascadeReaction:ArylAddition/IntramolecularEsterificationtoAccess3-Aryland3-AlkenylPhthalides.Angew.Chem.Int.Ed.2010,49,3671-3674.
4.ZhishiYe,KristenE.Gettys,XingyuShen,andMingjiDai.*Copper-CatalyzedCyclopropanolRingOpeningCsp3-Csp3CrossCouplingswith(Fluoro)AlkylHalides.Org.Lett.2015,17,6074-6077.
5.ZhishiYe,TarsisF.Brust,ValJ.Watts,*andMingjiDai.*Palladium-CatalyzedRegio-andStereoselectiveγ-ArylationofTertiaryAllylicAmines:IdentificationofPotentAdenylylCyclaseInhibitors.Org.Lett.2015,17,892–895.
6.ZhishiYe,andMingjiDai.*AnUmpolungStrategyfortheSynthesisofβ-AminoketonesviaCopper-CatalyzedElectrophilicAminationofCyclopropanols.Org.Lett.2015,17,2190–2193.
7.YongLi?,ZhishiYe?,TabithaM.Bellman,TengChi,andMingjiDai.*EfficientSynthesisofβ-CF3/SCF3-SubstitutedCarbonylsviaCopper-CatalyzedElectrophilicRing-OpeningCross-CouplingofCyclopropanols.Org.Lett.2015,17,2186–2189.(?Theseauthorscontributedequally)
8.ZhishiYe,WenhuiWang,FangLuo,ShouhuiZhang,andJiangCheng.*Rhodium-Catalyzedortho-Benzoxylationofsp2C-HBond.Org.Lett.2009,11,3974-3977.
9.ZhishiYe,PengchengQian,GuangleiLv,FangLuo,andJiangCheng.*Palladium-CatalyzedCascadeArylAddition/IntramolecularLactonizationofPhthalaldehydetoAccess3-Aryl-andAlkenylphthalides.J.Org.Chem.2010,75,6043-6045.
10.ZhishiYe,LeiShi,*andYong-GuiZhou.AsymmetricHydrogenationofAromaticCarbocyclicRingsandThiophenes.Synlett2014,25,928-931.
11.ZhishiYe,MiaochangLiu,BaodaLin,HuayueWu,JinchangDing,andJiangCheng.*Palladium-CatalyzedCross-CouplingReactionofArylTrimethoxysilaneswithTerminalAlkynes.TetrahedronLett.2009,50,530-532.
12.ZhishiYe,FanChen,FangLuo,WenhuiWang,BaodaLin,XiaofeiJia,andJiangCheng.*Palladium-CatalyzedMizoroki-Heck-TypeReactionofArylTrimethoxysilanes.Synlett2009,2198-2200.
13.ZhishiYe,KristenE.Gettys,andMingjiDai.*OpportunitiesandChallengesforDirectC–HFunctionalizationofPiperazines.BeilsteinJ.Org.Chem.2016,12,702–715.
14.KristenE.Gettys,ZhishiYe,MingjiDai.*RecentAdvancesinPiperazineSynthesis.Synthesis,2017,49,2589-2604.
15.Mu-WangChen,Zhi-ShiYe,Zhang-PeiChen,BoWu,andYong-GuiZhou.*EnantioselectiveSynthesisofTrifluoromethylSubstitutedPiperidineswithMultipleStereogenicCentersviaHydrogenationofPyridiniumHydrochlorides.Org.Chem.Front.2015,2,586-589.
16.Zhang-PeiChen,Zhi-ShiYe,Mu-WangChen,andYong-GuiZhou.*EnantioselectiveSynthesisofEndo-CyclicBeta-AminoAcidswithTwoContiguousStereocentersviaHydrogenationof3-Carbalkoxy-2-SubstitutedQuinolines.Synthesis2013,3239-3244.
17.Qing-AnChen,Zhi-ShiYe,YingDuanandYong-GuiZhou*Homogeneouspalladium-catalyzedasymmetrichydrogenation.Chem.Soc.Rev.2013,42,497-511.
18.LeiShi,Zhi-ShiYe,Liang-LiangCao,Ran-NingGuo,YueHu,Yong-GuiZhou.*EnantioselectiveIridium-CatalyzedHydrogenationof3,4-DisubstitutedIsoquinolines.Angew.Chem.Int.Ed.2012,51,8286-8289.
19.Duo-ShengWang,Zhi-ShiYe,Qing-AnChenandYong-GuiZhou,*Chang-BinYu,Hong-JunFan,*andYingDuan.EnantioselectivePartialHydrogenationofSimplePyrroles:AFacileAccesstoChiral1-Pyrrolines.J.Am.Chem.Soc.2011,133,8866-8869.
20.Liang-LiangCao,Zhi-ShiYe,Guo-FangJiang*andYong-GuiZhou.*Rhodium-CatalyzedAdditionofBoronicAcidstoVinylogousIminesGeneratedinsitufromSulfonylindoles.Adv.Synth.Catal.2011,3352-3356.
21.BoWu,Mu-WangChen,Zhi-ShiYe,Chang-BinYu,andYong-GuiZhou.*AStreamlinedSynthesisof2,3-Dihydrobenzofuransviatheortho-QuinoneMethidesGeneratedfrom2-Alkyl-SubstitutedPhenols.Adv.Synth.Catal.2014,356,383-387.
22.Mu-WangChen,Liang-LiangCao,Zhi-ShiYe,Guo-FangJiangandYong-GuiZhou.*AMildMethodforGenerationofo-QuinoneMethideundertheBasicCondition.TheFacileSynthesisoftrans-2,3-Dihydrobenzofurans.Chem.Commun.2013,49,1660-1662.
23.YingDuan,Mu-WangChen,Zhi-ShiYe,Duo-ShengWang,Qing-AnChen,andYong-GuiZhou.*AnEnantioselectiveApproachto2,3-DisubstitutedIndolinesthroughConsecutiveBronstedAcid/Pd-Complex-PromotedTandemReactions.Chem.Eur.J.2011,17,7193-7197.
24.Xian-FengCai,Mu-WangChen,Zhi-ShiYe,Ran-NingGuo,LeiShi,Yan-QinLiandYong-GuiZhou.*AsymmetricTransferHydrogenationofAromaticNitroCompounds,3-Nitroquinolines:AFacileAccesstoCyclicNitroCompoundswithTwoContiguousStereocenters.Chem.AsianJ.2013,8,1381-1385.
25.Ran-NingGuo,Xian-FengCai,LeiShi,Zhi-ShiYe,Mu-WangChenandYong-GuiZhou.*AnEfficientRoutetoChiralN-HeterocyclesBearingC-FStereogenicCenterviaAsymmetricHydrogenationofFluorinatedIsoquinolines.Chem.Commun.2013,49,8537-8539.
26.Qing-AnChen,KaiGao,YingDuan,Zhi-ShiYe,LeiShi,YanYangandYong-GuiZhou.*Dihydrophenanthridine:ANewandEasilyRegenerableNAD(P)HModelforBiomimeticAsymmetricHydrogenation.J.Am.Chem.Soc.2012,134,2442-2448.
27.KaiGao,BoWu,Chang-BinYu,Qing-AnChen,Zhi-ShiYeandYong-GuiZhou.*IridiumCatalyzedAsymmetricHydrogenationofCyclicIminesofBenzodiazepinonesandBenzodiazepines.Org.Lett.2012,14,3890–3893.
28.Mu-WangChen,Qing-AnChen,YingDuan,Zhi-ShiYeandYong-GuiZhou.*AsymmetricHydrogenolysisofRacemicTertiaryAlcohol,3-Substituted3-Hydroxyisoindolin-1-ones.Chem.Commun.2012,48,1698-1700.
29.Ran-NingGuo,KaiGao,Zhi-ShiYe,LeiShi,YanqinLiandYong-GuiZhou.*Iridium-CatalyzedAsymmetricHydrogenationofDibenzo[b,f][1,4]thiazepines.PureAppl.Chem.2013,85,843-849.
30.FangLuo,ChangduoPan,WenhuiWang,ZhishiYe,andJiangCheng.*Palladium-catalyzedreductionofalkynesemployingHSiEt3:stereoselectivesynthesisoftrans-andcis-alkenes.Tetrahedron2010,66,1399-1403.
31.BaodaLin,MiaochangLiu,ZhishiYe,QinZhang,andJiangCheng.*Rhodium-copper-TBAF-catalyzedhydroarylationofalkyneswitharyltrimethoxysilanes.TetrahedronLett.2009,50,1714-1716.
32.BaodaLin,MiaochangLiu,ZhishiYe,JinchangDing,HuayueWu,andJiangCheng.*Copper-TBAFcatalyzedarylationofaminesandamideswitharyltrimethoxysilane.Org.Biomol.Chem.2009,7,869-873.
33.TarsisF.Brust,DoungkamolAlongkronrusmee,MonicaSoto-Velasquez,TanyaA.Baldwin,ZhishiYe,MingjiDai,CarmenW.Dessauer,RichardM.vanRijn,andValJ.Watts.*Identificationofaselectivesmall-moleculeinhibitoroftype1adenylylcyclaseactivitywithanalgesicproperties.Sci.Signal.2017,10,5381-5391.

科研工作 :
叶智识博士特聘研究员

大连理工大学-化工与环境生命学部-张大煜学院

联系邮箱；yzhsh1984@dlut.edu.cn


2017年9月-至今：大连理工大学，化工与环境生命学部-张大煜学院

2013年8月-2017年8月：美国普渡大学-博士后，导师：代明骥教授

2010年9月-2013年7月：中科院大连化学物理研究所-博士，导师：周永贵研究员

2007年9月-2010年7月：温州大学-硕士，导师：成江教授

2003年9月-2007年7月：温州大学-本科

从事过渡金属催化和有机合成研究。在过渡金属催化的有机合成方法学、不对称催化及杂环合成等领域开展了多项创新性研究，取得了多项创新成果。在Chem.Soc.Rev.,Angew.Chem.Int.Ed.，J.Am.Chem.Soc.,Org.Lett.等国际权威期刊上发表文章33篇，总引用次数1121次，H-因子为20(截止2017年10月)。获得辽宁省自然科学一等奖（第四完成人）、中国科学院院长优秀奖和浙江省优秀硕士毕业论文。


代表论文：

1.Zhi-ShiYe,Ran-NingGuo,Xian-FengCai,Mu-WangChen,LeiShi,andYong-GuiZhou.*EnantioselectiveIridium-CatalyzedHydrogenationof1-and3-SubstitutedIsoquinoliniumSalts.Angew.Chem.Int.Ed.2013,52,3685-3689.
2.Zhi-ShiYe,Mu-WangChen,Qing-AnChen,LeiShi,YingDuan,andYong-GuiZhou.*Ir-CatalyzedAsymmetricHydrogenationofPyridiniumSalts.Angew.Chem.Int.Ed.2012,51,10181-10184.
3.ZhishiYe,GuangleiLv,WenhuiWang,ManliZhang,andJiangCheng.*Rhodium-CatalyzedCascadeReaction:ArylAddition/IntramolecularEsterificationtoAccess3-Aryland3-AlkenylPhthalides.Angew.Chem.Int.Ed.2010,49,3671-3674.
4.ZhishiYe,KristenE.Gettys,XingyuShen,andMingjiDai.*Copper-CatalyzedCyclopropanolRingOpeningCsp3-Csp3CrossCouplingswith(Fluoro)AlkylHalides.Org.Lett.2015,17,6074-6077.
5.ZhishiYe,TarsisF.Brust,ValJ.Watts,*andMingjiDai.*Palladium-CatalyzedRegio-andStereoselectiveγ-ArylationofTertiaryAllylicAmines:IdentificationofPotentAdenylylCyclaseInhibitors.Org.Lett.2015,17,892–895.
6.ZhishiYe,andMingjiDai.*AnUmpolungStrategyfortheSynthesisofβ-AminoketonesviaCopper-CatalyzedElectrophilicAminationofCyclopropanols.Org.Lett.2015,17,2190–2193.
7.YongLi?,ZhishiYe?,TabithaM.Bellman,TengChi,andMingjiDai.*EfficientSynthesisofβ-CF3/SCF3-SubstitutedCarbonylsviaCopper-CatalyzedElectrophilicRing-OpeningCross-CouplingofCyclopropanols.Org.Lett.2015,17,2186–2189.(?Theseauthorscontributedequally)
8.ZhishiYe,WenhuiWang,FangLuo,ShouhuiZhang,andJiangCheng.*Rhodium-Catalyzedortho-Benzoxylationofsp2C-HBond.Org.Lett.2009,11,3974-3977.
9.ZhishiYe,PengchengQian,GuangleiLv,FangLuo,andJiangCheng.*Palladium-CatalyzedCascadeArylAddition/IntramolecularLactonizationofPhthalaldehydetoAccess3-Aryl-andAlkenylphthalides.J.Org.Chem.2010,75,6043-6045.
10.ZhishiYe,LeiShi,*andYong-GuiZhou.AsymmetricHydrogenationofAromaticCarbocyclicRingsandThiophenes.Synlett2014,25,928-931.
11.ZhishiYe,MiaochangLiu,BaodaLin,HuayueWu,JinchangDing,andJiangCheng.*Palladium-CatalyzedCross-CouplingReactionofArylTrimethoxysilaneswithTerminalAlkynes.TetrahedronLett.2009,50,530-532.
12.ZhishiYe,FanChen,FangLuo,WenhuiWang,BaodaLin,XiaofeiJia,andJiangCheng.*Palladium-CatalyzedMizoroki-Heck-TypeReactionofArylTrimethoxysilanes.Synlett2009,2198-2200.
13.ZhishiYe,KristenE.Gettys,andMingjiDai.*OpportunitiesandChallengesforDirectC–HFunctionalizationofPiperazines.BeilsteinJ.Org.Chem.2016,12,702–715.
14.KristenE.Gettys,ZhishiYe,MingjiDai.*RecentAdvancesinPiperazineSynthesis.Synthesis,2017,49,2589-2604.
15.Mu-WangChen,Zhi-ShiYe,Zhang-PeiChen,BoWu,andYong-GuiZhou.*EnantioselectiveSynthesisofTrifluoromethylSubstitutedPiperidineswithMultipleStereogenicCentersviaHydrogenationofPyridiniumHydrochlorides.Org.Chem.Front.2015,2,586-589.
16.Zhang-PeiChen,Zhi-ShiYe,Mu-WangChen,andYong-GuiZhou.*EnantioselectiveSynthesisofEndo-CyclicBeta-AminoAcidswithTwoContiguousStereocentersviaHydrogenationof3-Carbalkoxy-2-SubstitutedQuinolines.Synthesis2013,3239-3244.
17.Qing-AnChen,Zhi-ShiYe,YingDuanandYong-GuiZhou*Homogeneouspalladium-catalyzedasymmetrichydrogenation.Chem.Soc.Rev.2013,42,497-511.
18.LeiShi,Zhi-ShiYe,Liang-LiangCao,Ran-NingGuo,YueHu,Yong-GuiZhou.*EnantioselectiveIridium-CatalyzedHydrogenationof3,4-DisubstitutedIsoquinolines.Angew.Chem.Int.Ed.2012,51,8286-8289.
19.Duo-ShengWang,Zhi-ShiYe,Qing-AnChenandYong-GuiZhou,*Chang-BinYu,Hong-JunFan,*andYingDuan.EnantioselectivePartialHydrogenationofSimplePyrroles:AFacileAccesstoChiral1-Pyrrolines.J.Am.Chem.Soc.2011,133,8866-8869.
20.Liang-LiangCao,Zhi-ShiYe,Guo-FangJiang*andYong-GuiZhou.*Rhodium-CatalyzedAdditionofBoronicAcidstoVinylogousIminesGeneratedinsitufromSulfonylindoles.Adv.Synth.Catal.2011,3352-3356.
21.BoWu,Mu-WangChen,Zhi-ShiYe,Chang-BinYu,andYong-GuiZhou.*AStreamlinedSynthesisof2,3-Dihydrobenzofuransviatheortho-QuinoneMethidesGeneratedfrom2-Alkyl-SubstitutedPhenols.Adv.Synth.Catal.2014,356,383-387.
22.Mu-WangChen,Liang-LiangCao,Zhi-ShiYe,Guo-FangJiangandYong-GuiZhou.*AMildMethodforGenerationofo-QuinoneMethideundertheBasicCondition.TheFacileSynthesisoftrans-2,3-Dihydrobenzofurans.Chem.Commun.2013,49,1660-1662.
23.YingDuan,Mu-WangChen,Zhi-ShiYe,Duo-ShengWang,Qing-AnChen,andYong-GuiZhou.*AnEnantioselectiveApproachto2,3-DisubstitutedIndolinesthroughConsecutiveBronstedAcid/Pd-Complex-PromotedTandemReactions.Chem.Eur.J.2011,17,7193-7197.
24.Xian-FengCai,Mu-WangChen,Zhi-ShiYe,Ran-NingGuo,LeiShi,Yan-QinLiandYong-GuiZhou.*AsymmetricTransferHydrogenationofAromaticNitroCompounds,3-Nitroquinolines:AFacileAccesstoCyclicNitroCompoundswithTwoContiguousStereocenters.Chem.AsianJ.2013,8,1381-1385.
25.Ran-NingGuo,Xian-FengCai,LeiShi,Zhi-ShiYe,Mu-WangChenandYong-GuiZhou.*AnEfficientRoutetoChiralN-HeterocyclesBearingC-FStereogenicCenterviaAsymmetricHydrogenationofFluorinatedIsoquinolines.Chem.Commun.2013,49,8537-8539.
26.Qing-AnChen,KaiGao,YingDuan,Zhi-ShiYe,LeiShi,YanYangandYong-GuiZhou.*Dihydrophenanthridine:ANewandEasilyRegenerableNAD(P)HModelforBiomimeticAsymmetricHydrogenation.J.Am.Chem.Soc.2012,134,2442-2448.
27.KaiGao,BoWu,Chang-BinYu,Qing-AnChen,Zhi-ShiYeandYong-GuiZhou.*IridiumCatalyzedAsymmetricHydrogenationofCyclicIminesofBenzodiazepinonesandBenzodiazepines.Org.Lett.2012,14,3890–3893.
28.Mu-WangChen,Qing-AnChen,YingDuan,Zhi-ShiYeandYong-GuiZhou.*AsymmetricHydrogenolysisofRacemicTertiaryAlcohol,3-Substituted3-Hydroxyisoindolin-1-ones.Chem.Commun.2012,48,1698-1700.
29.Ran-NingGuo,KaiGao,Zhi-ShiYe,LeiShi,YanqinLiandYong-GuiZhou.*Iridium-CatalyzedAsymmetricHydrogenationofDibenzo[b,f][1,4]thiazepines.PureAppl.Chem.2013,85,843-849.
30.FangLuo,ChangduoPan,WenhuiWang,ZhishiYe,andJiangCheng.*Palladium-catalyzedreductionofalkynesemployingHSiEt3:stereoselectivesynthesisoftrans-andcis-alkenes.Tetrahedron2010,66,1399-1403.
31.BaodaLin,MiaochangLiu,ZhishiYe,QinZhang,andJiangCheng.*Rhodium-copper-TBAF-catalyzedhydroarylationofalkyneswitharyltrimethoxysilanes.TetrahedronLett.2009,50,1714-1716.
32.BaodaLin,MiaochangLiu,ZhishiYe,JinchangDing,HuayueWu,andJiangCheng.*Copper-TBAFcatalyzedarylationofaminesandamideswitharyltrimethoxysilane.Org.Biomol.Chem.2009,7,869-873.
33.TarsisF.Brust,DoungkamolAlongkronrusmee,MonicaSoto-Velasquez,TanyaA.Baldwin,ZhishiYe,MingjiDai,CarmenW.Dessauer,RichardM.vanRijn,andValJ.Watts.*Identificationofaselectivesmall-moleculeinhibitoroftype1adenylylcyclaseactivitywithanalgesicproperties.Sci.Signal.2017,10,5381-5391.

教育背景 :
2000.32005.4大连理工大学固体力学博士1985.91987.7大连工学院计算力学硕士1981.91985.7辽宁大学计算数学学士