导师姓名：宋刚
性别：男
人气指数：1456

所属院校：厦门大学
所属院系：医学院
职称：教授
导师类型：
招生专业：生理学
研究领域： 信号转导和肿瘤防治
研究领域： 信号转导和肿瘤防治 [收起]




通讯方式 :
办公电话：**
电子邮件：gangsongsd@xmu.edu.cn
通讯地址：厦门市思明区大学路172号


科研工作 :

目前主要从事“基于Bid、Osteopontin等分子靶点的消化道肿瘤发生发展过程中的信号转导机制；间充质干细胞（MSCs）对炎症、炎症性肿瘤的调控；抗炎、抗癌药物筛选及其药理研究等。近年来，在SCI收录期刊上发表论文30余篇，已被引用1000余次。主持国家自然科学基金面上项目（**，**）、教育部部属高校教师科研业务费专项基金（**）、福建省新世纪优秀人才支持计划项目（2011）、福建省科公益研院所专项基金（2010R1039-2）及厦门市科技计划项目（3502Z**）等多项研究课题。申请发明专利1项. 教学方面，承担过本科生课程有：“医学细胞生物学”、“医学生物化学”和“医学生物化学与分子生物学实验课”；承担研究生课程有：“肿瘤细胞分子生物学”和“医学科研设计”。
近年来发表的论文(* Corresponding author)：
1.Zhou H， Xu MY， Gao Y， Deng ZG， Cao HW， Zhang WQ， Wang Q， Zhang B， Song G*， Zhan YY*， Hu TH*. Matrine Induces Caspase-Independent Program Cell Death in Hepatocellular Carcinoma through Bid-Mediated Nuclear Translocation of Apoptosis Inducing Factor. Mol Cancer. 2014， Accepted.
2.Wang Q， Du H， Geng G， Zhou H， Xu M， Cao H， Zhang B， Song G*， Hu T*. Matrine inhibits proliferation and induces apoptosis via BID-mediated mitochondrial pathway in esophageal cancer cells. Mol Biol Rep. 2014 Feb 8. [Epub ahead of print]
3.Li J， Zhong W， Wang WW， Hu S， Yuan J， Zhang B， Hu TH， Song G*. Ginsenoside metabolite compound K promotes recovery of dextran sulfate sodium-induced colitis and inhibits inflammatory responses by suppressing NF-кB activation. PLoS One. 2014 9(2):e87810. doi: 10.1371/journal.pone.**.
4.Li J， Hu SP， Yuan JH， Zhong W， Song G*. BID is a potential link between DNA damage and inflammatory responses in tumorigenesis. OA Medical Hypothesis. 2013 Dec 211(2):19. www.oapublishinglondon.com/images/article/pdf/**.pdf
http://www.oapublishinglondon.com/images/article/pdf/**.pdf
5.Lin DJ， Zhong W， Li J， Zhang B， Song G*， Hu TH. Involvement of BID translocation in glycyrrhetinic acid and 11-deoxy glycyrrhetinic acid-induced attenuation of gastric cancer growth. Nutr Cancer. 2014 Feb 18. [Epub ahead of print]
6.Lin F， Yan W， Song G， Wen T， Hu T， Wu G. Metformin Targets Liver Tumor-Initiating Cells Through the PI3K/Akt/mTOR Survival Pathway. Chinese sci bull， 2013， accepted.
7.Zhang JF， Cao HL， Zhang B， Cao HW， Xu XQ， Ruan H， Yi TT， Tan L， Qu R， Song G*， Wang BM*， Hu TH*. Berberine Potently Attenuates Intestinal Polyps Growth in ApcMin mice and Familial Adenomatous Polyposis Patients through Inhibition of Wnt Signaling. J Cell Mol Med. July， 2013. 17(11):1484-93.
8.Mao Y， Xu J， Song G， Zhang N， Yin H. Twist2 promotes ovarian cancer cell survival through activation of Akt. Oncol Lett. 2013，6(1):169-174.
9.Li Y， Dai C， Li J， Wang W， Song G*. Bid-overexpression regulates proliferation and phosphorylation of Akt and MAPKs in response to etoposide-induced DNA damage in hepatocellular carcinoma cells. OncoTargets and Therapy. 2012，5:279-286.
10.Hu C#， Song G#，*， Zhang B， Liu Z， Chen R， Hu TH*. Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway. J Cell Mol Med. 2012， 16(1):96-106. (# Co-first authors， * Co-Corresponding author).
11.Huang JG， Xia C*， Zheng XP， Yi TT， Wang XY， Song G， Zhang B. 17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/AKT pathway. Cell Mol Biol Lett. 2011， 16(4):564-75.
12.Song G*， Wang WW， Hu Th. p53 facilitates BH3-only BID nuclear export to induce apoptosis in the irrepairable DNA damage response. Medical Hypotheses， 2011， 77(5): 850-852.
13.Ming YL， Chen ZY， Chen LH， Lin DJ， Tong QX， Zheng ZZ， Song G*. Ginsenoside compound K attenuated metastatic growth of hepatocellular carcinoma is associated with the translocation of Nuclear factor-кB p65 and reduction of matrix metalloproteinase2/9. Planta Medica， 2011， 77（5）: 428-433.
14.Song G*， Guo S， Wang W， Hu C， Mao Y， Zhang B， Hu T*. Intestinal metabolite compound K of ginseng saponin potently attenuating metastatic growth of hepatocellular carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway. J Agric Food Chem. 2010， 58（24）: 12753-60.
15.Song G， Chen GG*， Hu TH and Lai PBS. Bid Stands at the Crossroad of Stress-response Pathways. Current Cancer Drug Targets. 2010. 10 (6): 584-592.
16.Gang Song*， Shiguang Guo， Bing Zhang， and Tianhui Hu. Effects of Bid-Overexpression on Hepatocellular Carcinoma Cells Proliferation in Response to Etoposide-induced DNA Damage. Scientific and Technical Development Press， 2010， p407-411.
17.Song G， Ouyang G， Mao YB， Ming YL， Bao S， Hu TH*. Osteopontin promotes metastatic growth of gastric cancer by augmenting cell survival and invasion through Akt-mediated HIF-1α up-regulation and MMP9 activation. J Cell Mol Med. 2009， 13(8B):1706-1718.
18.Song G， Chen GG， Yun JP and Lai PBS. Association of p53 with Bid induces cell death in response to etoposide treatment in hepatocellular carcinoma. Current Cancer Drug Targets. 2009， 9(7): 871-880.
19.Song G， Cai QF， Mao YB， Ming YL， Bao S， Ouyang G*. Osteopontin promotes ovarian cancer progression and cell survival and increases HIF-1α expression through the PI3-K/Akt pathway. Cancer Sci. 2008， 10: 1901-1907.
20.Song G， Ming Y， Mao Y， Bao S， Ouyang G*. Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via {alpha}v{beta}3 integrins in human gastric cancer cells. Exp Biol Med. 2008 233(12):1537-1545.
21.Song G， Chen GG*， Chau DK， Miao J， Lai PBS. Bid exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to etoposide-induced DNA damage in hepatocellular carcinoma cells. Apoptosis. 2008， 13(5): 693-701.
22.Song G， Ouyang G， Bao S*. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med. 2005， 9(1): 59-71.
23.Song G， Mao YB， Cai QF， Yao LM， Ouyang GL*， Bao SD. Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis via activating p53 and regulating apoptosis-related proteins. Braz J Med Biol Res. 2005， 38 (12): 1791-1798.
24.Ming YL， Song G， Chen LH， Zheng ZZ， Chen ZY， Ouyang G*， Tong QX. Anti-proliferation and apoptosis induced by a novel intestinal metabolite of ginseng saponin in human hepatocellular carcinoma cells. Cell Biol Int. 2007， 31:1265-1273.
25.Mao YB， Song G， Cai QF， Liu M， Luo HH， Shi MX， Ouyang GL， Bao SD*. P53 involves in hydrogen peroxide-induced apoptosis in Human MGC803 cells. Cell Biol Int. 2006， 30:332-337.
26.Ouyang G*， Yao L， Ruan K， Song G， Mao Y， Bao S.Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. Cell Biol Int. 2009， 33(12):1237-1244.
27.Ouyang G*， Liu M， Ruan K， Song G， Mao Y， Bao S.Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway. Cancer Lett. 2009， 281(2):213-219.
28.Ruan K， Song G， Ouyang GL*. Role of hypoxia in human cancer. Journal of Cellular Biochemistry. 2009，107:1053-1062.

Contact Information：
Tel：** Fax：** E-mail：gangsongsd@xmu.edu.cn


教育背景 :
博士、教授；福建省高等学校新世纪优秀人才支持计划和厦门市重点人才入选者；福建省细胞生物学学会理事；福建省生物工程学会理事；《临床个性化医学》编委，JCellMolMed等多个杂志审稿人。
烟台师范学院生物系本科（1994），福建农林大学园艺生物技术硕士（1998），厦门大学细胞生物学专业博士（2003），香港中文大学癌症研究中心（ResearchAssociate，2006-2008）。2008年被聘为厦门大学医学院副教授。2011年被聘为厦门大学医学院教授，在抗癌研究中心从事教学和科研工作。