杜宏武

教授生物科学与工程系副主任

办公地点： 理化楼112

办公电话： 62334497

电子邮件： hongwudu@ustb.edu.cn

本科课程： 《生物芯片》 《现代生物技术导论》 《生命科学导论》 《生物工程》 《专业前沿进展讲座I》

科研方向： 生物制药 临床诊断试剂 药物新靶点 生物芯片 功能蛋白质组学 系统生物学和转化医学

简历

北科大422引进人才、北京市科技新星、教育部新世纪优秀人才 2009年6月-2011年6月：斯坦福大学医学院，Staff Scientist。 2007年1月-今：北京科技大学，系副主任，副教授，硕士生导师。 2000年10月-2005年11月：生物芯片国家工程研究中心，高级科学家、免疫技术部副主任。 2000年9月-2005年1月：清华大学医学院，理学博士。 1997年9月-2000年7月：中国协和医科大学（中国医学科学院），理学硕士。 1993年9月-1997年7月：山东大学生命科学学院，理学本科。

科研业绩

先后主持国家自然科学基金（3项），教育部重点/新世纪，科技部科技支撑等多项科研课题。

获得奖励/专利

北京市“科技新星” （2007）； 国家“科技奥运先进个人”（2008）； 美国斯坦福“HIMC杰出贡献奖”（2011）； 生物芯片国家工程中心最高科研贡献奖； 美国HIMC杰出研究特别贡献奖； 世界反兴奋剂机构临床诊断试剂评比第一名。

代表性论文论著

1. X. Wang, P. Chen, J. Cui, C. Yang and Du H. Keratin 8 is a novel autoantigen of rheumatoid arthritis. Biochem Biophys Res Commun. (2015) 30390-9.

2. C.C. Whiting, J. Siebert, A.M. Newman, Du H, A.A. Alizadeh, J. Goronzy, C.M. Weyand, E. Krishnan, C.G. Fathman and H.T. Maecker. Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging. PLoS One. (2015) e133627.

3. J. Liang, W. Yang, X. Meng, P. Chen and Du H. Heterogeneous Nuclear Ribonucleoprotein A2/B1 as a Target Antigen in Han Chinese for BD Patients. Protein Pept Lett. (2015) 504-508.

4. Du H, G. Chen, Y. Bian, C. Xing, X. Ding, M. Zhu, Y. Xun, P. Chen, Y. Zhou and S. Li, Screening hybridomas for anabolic androgenic steroids by steroid analog antigen micro. Bioanalysis. (2015) 1201-1209.

5. Y. Xun, G. Chen and H. Du. Combinatorial Application of Multiple High-throughput Biotechnologies for the Study of Autoimmune Diseases. Current Pharmaceutical Analysis. (2015) 156-163.

6. L. Shi, P. Chen, Y. Xun, W. Yang, C. Yang, G. Chen and H. Du. Prohibitin as a novel autoantigen in rheumatoid arthritis. Central European Journal of Immunology. (2015) 78-82.

7. H. Du, L. Shi, P. Chen, W. Yang, Y. Xun, C. Yang, L. Zhao, Y. Zhou and G. Chen. Prohibitin is Involved in Patients with IgG4 Related Disease. PLoS One (2015) 10(5):e0125331.

8. P. Chen, W. Yang, Y. Tian, S. Sun, G. Chen, C. Zhang, F. Ma, Y. Xun, L. Shi and H. Du. Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behçet’s Disease. PLoS One. (2015) 10(4):e0124760.

9. P. Chen, H. Yan, Y. Tian, Y. Xun, L. Shi, R. Bao, H. Zhang, G. Chen, C. Yang, S. Sun, Y. Wang, L. Liu, Y. Zhou, C. Zhang, X. Wang, Y. Wen, Y. Bian and Du H. Annexin A2 as a target endothelial cell membrane autoantigen in Behcet's disease. Sci Rep. (2015) 8162.

10. P. Chen, L. Shi, Y. Jiang, Y. Ji, H. Yan, S. Sun, Y. Xun, G. Chen, X. Wang, W. Chen and Du H. Identification of heat shock protein 27 as a novel autoantigen of Behcet's disease. Biochem Biophys Res Commun. (2015) 456(4):866-71.

11. Z. Kang, X. Yan, L. Zhao, Q. Liao, K. Zhao, H. Du, X. Zhang, X. Zhang and Y. Zhang. Gold nanoparticle/ZnO nanorod hybrids for enhanced reactive oxygen species generation and photodynamic therapy. Nano Research. (2015) 1-11.

12. M. Zhu, Y. Zhou, L. Yang, L. Li, D. Qi, M. Bai, Y. Chen, Du H and Y. Bian. Synergistic Coupling of Fluorescent "Turn-Off" with Spectral Overlap Modulated FRET for Ratiometric Ag(+) Sensor. Inorg Chem. (2014) 12186-12190.

13. Du H, G. Chen, C. Yang, C. Li, Y. Xun, J. Liu, P. Chen and L. Shi. Multiple correlations of mRNA expression and protein abundance in human cytokine profile. Mol Biol Rep. (2014) 6985-6993.

14. Y. Xun, P. Chen, H. Yan, W. Yang, L. Shi, G. Chen and Du H. Identification of prohibitin as an antigen in Behcet's disease. Biochem Biophys Res Commun. (2014) 389-393.

15. L. Sun, J. Lin, Du H, C. Hu, Z. Huang, Z. Lv, C. Zheng, X. Shi, Y. Zhang and Z. Yang. Gender-specific DNA methylome analysis of a Han Chinese longevity population. Biomed Res Int. (2014) 396727.

16. H. Du, J. Liu, Y. Xun, J. Liang, S. Li and G. Chen. Determination of Deoxynivalenol, Zearalenone, Aflatoxin B1, and Ochratoxin by an Enzyme-Linked Immunosorbent Assay. Anal Lett. (2014) 1-9.

17. W. Wang, Y. Wen, L. Xu, Du H, Y. Zhou and X. Zhang. A selective release system based on dual-drug-loaded mesoporous silica for nanoparticle-assisted combination therapy. Chemistry. (2014) 7796-7802.

18. Y. Zhao, X. Yan, Z. Kang, X. Fang, X. Zheng, L. Zhao, H. Du and Y. Zhang. Zinc oxide nanowires-based electrochemical biosensor for L-lactic acid amperometric detection. Journal of Nanoparticle Research. (2014) 1-9.

19. L.L. Ritterhouse, R. Lu, H.B. Shah, J.M. Robertson, D.A. Fife, H.T. Maecker, Du H, C.G. Fathman, E.F. Chakravarty, R.H. Scofield, D.L. Kamen, J.M. Guthridge and J.A. James. Vitamin d deficiency in a multiethnic healthy control cohort and altered immune response in vitamin d deficient European-american healthy controls. PLoS One. (2014) e94500.

20. L. Chen, W. Wang, B. Su, Y. Wen, C. Li, Y. Zhou, M. Li, X. Shi, Du H, Y. Song and L. Jiang. A light-responsive release platform by controlling the wetting behavior of hydrophobic surface. ACS Nano. (2014) 744-751.

21. Du H, C. Li, H. Jin, G. Chen and Y. Xun. Generation and evaluation of antibodies against human MGF E-peptide by reverse phase protein micro and reverse competitive ELISA. Bioanalysis. (2013) 2269-2275.

22. L.P. Xu, Y. Liu, J. Zhao, S. Wang, C.S. Lin, R.Q. Zhang, Y. Wen, Du H and X. Zhang. Self-assembly of thiophene derivatives on highly oriented pyrolytic graphite: hydrogen bond effect. J Nanosci Nanotechnol. (2013) 1226-1231.

23. S. Wang, L.P. Xu, Y. Wen, Du H, S. Wang and X. Zhang. Space-confined fabrication of silver nanodendrites and their enhanced SERS activity. Nanoscale. (2013) 4284-4290.

24. X. Liu, P. Lin, X. Yan, Z. Kang, Y. Zhao, Y. Lei, C. Li, H. Du and Y. Zhang, Enzyme-coated single ZnO nanowire FET biosensor for detection of uric acid, Sensors and Actuators B: Chemical 176 (2013) 22-27.

25. Y. Wen, W. Wang, Z. Zhang, L. Xu, Du H, X. Zhang and Y. Song, Controllable and reproducible construction of a SERS substrate and its sensing applications, Nanoscale 5 (2013) 523-526.

26. Du H, G. Chen, S. Wang, S. Wang, S. Li, C. Li, Y. Xun, C. He and M. Wu, Immunological screening and characterization of highly specific monoclonal antibodies against 20 kDa hGH, Bioanalysis 4 (2012) 2161-2168.

27. Y. Wen, L. Xu, C. Li, Du H, L. Chen, B. Su, Z. Zhang, X. Zhang and Y. Song, DNA-based intelligent logic controlled release systems, Chem Commun (Camb) 48 (2012) 8410-8412.

28. H. Dong, J. Zhang, H. Ju, H. Lu, S. Wang, S. Jin, K. Hao, Du H and X. Zhang, Highly sensitive multiple microRNA detection based on fluorescence quenching of graphene oxide and isothermal strand-displacement polymerase reaction, Anal Chem 84 (2012) 4587-4593.

29. Y. Wen, L. Chen, W. Wang, L. Xu, Du H, Z. Zhang, X. Zhang and Y. Song, A flexible DNA modification approach towards construction of gold nanoparticle assemblies, Chem Commun (Camb) 48 (2012) 3963-3965.

30. H. Du, C. Li, G. Chen, H. Jin, T. Hua, S. Li and X. Zhang, Multiple Foreign Gene Delivery Can Induce Antibody Production in Mice, Anal Lett. (2012) 641-644.

研究生培养情况