导师姓名：欧和生
性别：男
人气指数：52

所属院校：广西医科大学
所属院系：药学院
职称：教授
导师类型：硕导/博导
招生专业：药理学
研究领域： 1.心血管分子药理学2.microRNA与基因调控
研究领域： 1.心血管分子药理学2.microRNA与基因调控 [收起]




个人简述 :
欧和生，男，药理学教授，博士生导师；1965年出生于湖南省永州市。1987年毕业于南华大学医学系医疗专业（本科），1992年取得医学硕士学位，1999年取得北京大学医学博士学位。1999年至2005年间留学美国，分别在芝加哥大学，罗彻斯特大学，贝勒医学院等著名学府从事心血管疾病和糖尿病分子病理学研究。2005年回国。在国内外杂志上发表专业论文60余篇，其中SCI论文27篇，包括国际一流杂志Nature?Medicine,?PNAS,?Rirc?Res,?Circulation,?Endocriology等，总影响因子113.76，最高27.13；第一或通讯作者总影响因子71.78，最高9.77。获得中国高校科学技术奖（自然科学奖）二等奖一次；分别在2006、2008和2014年获得国家自然基金面上项目（主持）。2013和2014年度的硕士研究生和博士研究生获得广西研究生创新课题。主要研究领域是心血管和糖尿病分子药理学，近年来从事microRNA的生物学功能及其在人类重大疾病（如高血压，糖尿病，癌症）中的临床应用价值研究。

科研工作 :
发表主要SCI文章如下：1.Ou?H,?Haendeler?J,?Aebly?MR,?Kelly?LA,?Cholewa?BC,?Koike?G,?Kwitek-Black?A,?Jacob?HJ,?Berk?BC,?Miano?JM.?Retinoic???acid-induced?tissue?transglutaminase?and?apoptosis?in?vascular?smooth?muscle?cells.?Circ?Res?2000?Nov?1087(10):881-7??(IF:?9.214)2.Zhou?S,?Shibusawa?N,?Naik?K,?Porras?D,?Temple?K,?Ou?H,?Brady?M,?Wondisford?FE.?Insulin?Regulation?of?Hepatic?Gluconeogenesis?through?Phosphorylation?of?CREB?Binding?Protein?(CBP).?Nature?Medicine,?2004?Jun10(6):633-7.?(IF?:27.136)3.Ou?H,?Yan?L,?Osmanovic?S,?Greenberg?C,?Brady?MJ.?Spatial?Organization?of?Glycogen?Synthesis?in?3T3-L1?Adipocytes.?Endocrinology,?2005?Jan146(1):494-502.?(IF?:4.752)4.Wang?X,?Lemaire?SA,?Chen?L,?Carter?SA,?Shen?YH,?Gan?Y,?Bartsch?H,?Wilks?JA,?Utama?B,?Ou?H,?Thompson?RW,?Coselli?JS,?Wang?XL.?Decreased?expression?of?fibulin-5?correlates?with?reduced?elastin?in?thoracic?aortic?dissection.Surgery.?2005?Aug138(2):352-9.?(IF?:3.603)5.OU?H,?Yan?L,?Makinen?M,?Mustafi?D,?and?Brady?MJ.?Insulin-Mimesis?of?Vanadyl?Chelates?Involves?Tyrosine?Phosphorylation?of?the?Insulin?Receptor.?Journal?of?Inorganic?Biol?Chem,?2005?Oct,19:1-13?(IF?:3.252)6.Ou?H,?Shen?YH,?Utama?B,?Wang?J,?Wang?X,?Coselli?J,?Wang?XL.?Effect?of?nuclear?actin?on?endothelial?nitric?oxide?synthase?expression.?Arteriocler?Thromb?Vas?Biol?,?2005；25(12):2509-14.?(IF?:7.235)7.Ou?H*,Zhang?MX*,?Shen?YH,?Wang?J,?Wang?J,?Coselli?J?and?Wang?XL.?Regulation?of?eNOS?expression?by?small?RNA.?Proc?Natl?Acad?Sci?USA,?2005；102(47):16967-72.(IF?:9.432)8.Wang?X,?LeMaire?SA,?Chen?L,?Shen?YH,?Gan?Y,?Bartsch?H,?Carter?SA,?Utama?B,?Ou?H,?Coselli?JS,?Wang?XL.?Increased?collagen?deposition?and?elevated?expression?of?connective?tissue?growth?factor?in?human?thoracic?aortic?dissection.?Circulation.?2006?Jul?4114(1?Suppl):I200-5?(IF?:14.916)9.Ling?HY,?Hu?B,?Wang?BX,?Zu?XY,?Feng?SD,?OU?H,?Zhou?SH,?Liao?DF.?Effects?of?Rosiglitazone?on?the?Proliferation?of?Vascular?Smooth?Muscle?Cell?Induced?by?High?Glucose.?Cardiovasc?Drugs?Ther,?2008?Dec22(6):453-60.?(IF?:2.515)10.Yan?L,?Hao?H,?Elton?TS,?Liu?Z,?Ou?H.?Intronic?microRNA?suppresses?endothelial?nitric?oxide?syntahse?expression?and?endothelial?cell?proliferation?via?inhibition?of?stat3?signaling.?Mol?Cell?Biochem,?2011,357(1-2):9-19.?(IF?:1.983)11.Kang?M,?Yan?LM,?Zhang?WY,?Li?YM,?Tang?AZ,?Ou?HS.?Role?of?microRNA-21?in?regulating?3T3-L1?adipocyte?differentiation?and?adiponectin?expression.?Molecular?Biology?Reports,?2013?Aug40(8):5027-34.?(IF:2.51)12.Kang?M,?Li?Y,?Liu?W,?Wang?R,?Tang?A,?Hao?H,?Liu?Z,?Ou?H.?MiR-129-2?suppresses????????proliferation?and?migration?of?esophageal?carcinoma?cells?through?down-regulation?of?SOX4?expression.?International?Journal?of?Molecular?Medicine,?2013?Jul32(1):51-8.?(IF:1.96)13.Yan?L,?Kang?M,?Qin?Z,?Zhang?W,?Li?Y,?Ou?H.?An?intronic?miRNA?regulates?expression?of?the?human?endothelial?nitric?oxide?synthase?gene?and?proliferation?of?endothelial?cells?by?a?mechanism?related?to?the?transcription?factor?SP-1.?PLoS?One.?2013?Aug?58(8):e70658.(IF:3.73)14.Kang?M,?Wang?RS,??Tang?AZ,?Ou?H.?Effect?of?trichosanthin?on?apoptosis?and?telomerase?activity?of?nasopharyngeal?carcinomas?in?nude?mice.?Journal?of?B.U.ON，2013?Jul-Sep18(3):675-82?（IF:?0.76）Li?Y,?Yan?L,?Zhang?W,?Wang?H,?Chen?W,?Hu?N,?Ou?H.?miR-21?inhibitor?suppresses?proliferation?and?migration?of?nasopharyngeal?carcinoma?cells?through?down-regulation?of?BCL2?expression.?Int?J?Clin?Exp?Pathol.?2014?May?157(6):3478-87.?eCollection?2014.??（IF:?2.24）15.Li?Y,?Yan?L,?Zhang?W,?Hu?N,?Chen?W,?Wang?H,?Kang?M,?Ou?H.?MicroRNA-21?inhibits?platelet-derived?growth?factor-induced?human?aortic?vascular?smooth?muscle?cell?proliferation?and?migration?through?targeting?activator?protein-1.?American?Jounal?of?Translational?Research.?2014,?(in?press)（IF:3.23）。