导师姓名：秦铭泽
性别：男
人气指数：68

所属院校：沈阳药科大学
所属院系：制药工程学院
职称：副教授
导师类型：硕导
招生专业：药物化学
研究领域： 基于免疫调控及表观遗传的抗肿瘤新药设计
研究领域： 基于免疫调控及表观遗传的抗肿瘤新药设计 [收起]




通讯方式 :
电子邮件：qinmingze001@126.com


个人简述 :
秦铭泽，男，博士，副教授。2009年毕业于沈阳药科大学，获药学学士学位，2014年于同校获药物化学博士学位。2017年被聘为沈阳药科大学副教授。作为课题负责人主持了国家自然科学基金青年基金1项，辽宁省博士启动基金1项，辽宁省教育厅一般项目1项，沈阳药科大学科研专项基金1项。目前已在Eur. J. Med. Chem., Bioorg.Med. Chem.等期刊发表论文10余篇。

科研工作 :
近年来发表代表性论文
1.YajingLiu, Di Yang, Zexin Hong, Su Guo, Moyi Liu, Daiying Zuo, Dandan Ge, Mingze Qin*, Deyu Sun*.Synthesis and biological evaluation of 4,6-diphenyl-2-(1H-pyrrol-1-yl)nicotinonitrile analogues of crolibulin andcombretastatin A-4. Eur. J. Med. Chem., 2018, 146: 185-193. (IF: 4.519)2.MingzeQin, Ye Tian, Xiaoqing Sun, Juanjuan Xia, Ping Gong, Haotian Zhang*,Yanfang Zhao*. Novel methyl indolinone-6-carboxylates containing anindole moiety as angiokinase inhibitors. Eur. J. Med. Chem., 2017, 139:492-502. (IF: 4.519)3.Mingze Qin*, Shuang Yan, LeiWang, Haotian Zhang, Ye Tian, Yanfang Zhao, Ping Gong*. Novel 6-MethoxycarbonylIndolinones Bearing a Pyrrole Mannich Base Moiety as Angiokinase Inhibitors.Bioorg. Med. Chem., 2017, 25, 1778-1786. (IF: 2.923)4.Yunlei Hou, Qi Shen, Zefei Li, ShaoweiChen, Yanfang Zhao, Mingze Qin*, PingGong*.Palladium-catalyzed three-component tandem reaction for one-pot highlystereoselective synthesis of (Z)-α-hydroxymethylallylic sulfones. Adv. Synth. Catal., DOI: 10.1002/adsc.**. 2018,360(4): 631-636. (IF: 5.646)5.Mingze Qin, Shuang Yan, Lei Wang,Haotian Zhang, Yanfang Zhao, Shasha Wu, Di Wu, Ping Gong*. Discoveryof novel diaryl area derivatives bearing a triazole moiety as potentialantitumor agents. Eur. J. Med. Chem., 2016, 115:1-13. (IF: 4.519)6.Mingze Qin*, Lei Wang,Shuang Yan, Junjie Ma, Ye Tian, Yanfang Zhao, and Ping Gong*.Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumoragents with selective inhibition of gefitinib-resistant H1975 cancer cells.Chinese Chem. Lett., 2017, 28, 991-994. (IF: 1.947)7.Yunlei Hou, Qi Shen, Liangyu Zhu,Yufei Han, Yanfang Zhao, Mingze Qin*, PingGong*.Palladium-catalyzed three-component tandem reaction of sulfonyl hydrazones,aryl iodides and allenes: highly stereoselective synthesis of (Z)-α-hydroxymethyl allylic sulfones. RSCadvances, 2017, 7, 50372-50377.8.Wenjing Ye, Qi Yao, Simiao Yu, PingGong, Mingze Qin*.Synthesis and antitumor activity of triazole-containing sorafenib analogs.Molecules, 2017, 22, 1759.9.YunleiHou#, Mingze Qin#,Xiuxiu Yang, Qi Shen, Yanfang Zhao, Yajing Liu*, and Ping Gong*.Palladium-catalyzed three-component tandem cyclization of buta-2,3-dien-1-ol,aryl iodides, and imines: an efficient protocol for the synthesis ofoxazolidine derivatives. RSC Adv., 2017, 7, 7401-7405. (IF: 3.289).10.Mingze Qin, Tingting Wang, Boxuan Xu,Zonghui Ma, Nan Jiang, Hongbo Xie, Ping Gong*, Yanfang Zhao*.Novel hydrazone moiety-bearing aminopyrimidines as selective inhibitors ofepidermal growth factor receptor T790M mutant. Eur. J. Med. Chem., 2015, 104:115-126. (IF: 3.902)