导师姓名：张惠斌
性别：女
人气指数：97

所属院校：中国药科大学
所属院系：药物科学研究院
职称：研究员
导师类型：博导
招生专业：药物化学
研究领域： 抗代谢性疾病药物研究
研究领域： 抗代谢性疾病药物研究 [收起]




通讯方式 :
办公电话：**
电子邮件：zhanghb80@163.com


个人简述 :
一直从事新药研究和开发工作。是国家自然科学基金评审专家、国家保健品评审专家，European Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry, Chinese Chemical Letters等杂志审稿人。负责国家自然科学基金、国家重大新药创制专项、江苏省产学研联合创新项目、江苏省自然科学基金等项目。承担本科生及研究生的“药物设计”“现代药化选论”专业课教学工作。负责撰写和申请专利20多项，已获得授权专利9项，发表论文80余篇。

科研工作 :
主要论文：1. Xing J, Li Q, Zhang S, Liu H, Zhao L, Cheng H, Zhang Y, Zhou J, Zhang H*. Identification of Dipeptidyl Peptidase IV Inhibitors: Virtual Screening, Synthesis and Biological Evaluation. Chem Biol Drug Des. 2014 , 84(3):364-77.2. Li Q, Xing J, Cheng H, Wang H, Wang J, Wang S, Zhou J, Zhang H*. Design, Synthesis, Antibacterial Evaluation and Docking Study of Novel 2-Hydroxy-3-(nitroimidazolyl)-propyl-derived Quinolone. Chem Biol Drug Des. 2014 Jul 21. doi: 10.1111/cbdd.123953. Jing Li, Huibin Zhang*, Wenlong Huang, Hai Qian and Ying Li. TNF-αInhibitors with Anti-Oxidative Stress Activity from Natural Products. Current Topics in Medicinal Chemistry, 2012, 12, 1408-14214. Huibin Zhang, Yaan Zhang, Guanzhong Wu, Jinpei Zhou, Wenlong Huang, Xiaowen Hu, Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents , Bioorganic & Medicinal Chemistry Letters, 2009, 19(6), 1740-17445. Yubin Wang, Hai Qian, Jinpei Zhou, Huibin Zhang*, and Jianfeng Ji and Wenlong Huang. Synthesis and Bioactivities of 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors. Medicinal Chemistry, 2011, 7, 534-5426. Wenyuan Liu, Ainan Zhou, Feng Feng, Huibin Zhang*, Jinpei Zhou, Wenlong Huang. Qualitative and quantitative studies on impurities in G004, a potential hypoglycaemic agent, using liquid chromatography, nuclear magnetic resonance and mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56, 627-6327. Wukun Liu, Jinpei Zhou, Kerstin Bensdorf , Huibin Zhang, Haoran Liu, YubinWang , Hai Qian,Yanchun Zhang, Anja Wellner, Gerhard Rubner, Wenlong Huang, Cancheng Guo, Ronald Gust. Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives. European Journal of Medicinal Chemistry, 2011, 46, 907-9138. Hui Bin Zhang, Yu Shi Chi, Wen Long Huang, Shuai Jian Ni. Total synthesis of human urotension-II by microwave-assisted solid phase method. Chinese Chemical Letters, 2007, 18 : 902–904.9. Yushi Chi, Huibin Zhang*, Wenlong Huang, Jinpei Zhou, Yinghong Zhou, Hai Qian, Shuaijian Ni. Microwave-assisted solid phase synthesis, PEGylation, and biological activity studies of glucagon-like peptide-1(7–36) amide，Bioorganic & Medicinal Chemistry, 2008, 16 (16),7607-761410. Chi, Yushi Zhang, Huibin* Zhou, Jinpei Huang, Wenlong Ni, Shuaijian, Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues, Letters in Organic Chemistry, 2008 5(5),399-402(4)11. Yu Li, Hui-bin Zhang*, Wenlong Huang, Yunman Li. Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer，Bioorganic & Medicinal Chemistry Letters, 2008, 18(12),3652-365512. Jing Li, Wenlong Huang, Huibin Zhang*, Xinyang Wang, Huiping Zhou. Synthesis of andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activities，Bioorganic & Medicinal Chemistry Letters, 2007,17(24) , 6891-689

教育背景 :
1984年获得中国药科大学制药化学学士学位，1989年获药物化学硕士学位，2004年获得博士学位。