导师姓名：秘晓林
性别：
人气指数：130

所属院校：大连医科大学
所属院系：基础医学院
职称：教授
导师类型：博导
招生专业：
研究领域： 1.DNA损伤导致的细胞周期调节、凋亡、转录调控的机制；2.非编码RNA（miRNA和ln... [展开]


研究领域： 1.DNA损伤导致的细胞周期调节、凋亡、转录调控的机制；2.非编码RNA（miRNA和lncRNA）对干细胞再生与分化的调控；3.肿瘤抑制因子调节细胞周期和凋亡，抑制肿瘤发生发展的作用机制。 [收起]




通讯方式 :
办公电话：**
电子邮件：xl2000bi@163.com


个人简述 :
秘晓林，博士，教授，博士生导师。 大连医科大学基础医学院副院长，生物科学系主任。入选中国科学 院“引进国外杰出人才--百人计划”，辽宁省“攀登学者”。国家科技奖、国家重大科学研究计划、自然科学基金、博士后科学基金、美 国国家科学基金研究生项目等评议人，SCI杂志International Journal of Nanomedicine顾问编委，Journal of Biochemistry and Molecular Biology Research编委，中国生化药物杂志编委，中国环境诱变剂学 会理事，Biomaterials、Genetics、Environmental Toxicology and Pharmacology、International Journal of Nanomedicine、PLoS One等 杂志审稿人。主持国家重点基础研究计划“973”项目课题、自然科 学基金面上项目、中国科学院创新项目等。 1990年毕业于兰州大学，获生物化学学士学位。1996年毕业于卫生 部兰州生物制品研究所，获免疫学和微生物学硕士学位。1999年毕业于中国预防医学科学院病毒学研究所，获病原生物学博士学位。 同年赴美国，在国立卫生研究院（National Institutes of Health）癌 症研究所（National Cancer Institute）从事博士后研究，随后任职美国国立卫生研究院癌症研究所高级研究学者。作为通讯作者，研究 成果发表在Proceedings of National Academy of Sciences USA, Oncogene, Human Molecular Genetics, Biomaterials, Journal of Cell Science, Nanotoxicology等国际一流学术期刊。

科研工作 :
代表性文章（*通讯作者）
1. Li D., Liu Y., Pei C., Zhang P., Pan L., Xiao J., Meng S., Yuan Z., Bi X. *A miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in Drosophila. Proceedings of National Academy of Sciences USA. 2017. (In press) IF 9.4
2. Cong W., Wang P., Qu Y., Tang J., Bai R., Zhao Y., Chen C. , Bi X. * Evalutation of the influence of Fullerenol on aging and stress resistance using Caenorhabditis elegans. Biomaterials. 2015. 42:78-86. IF 8.6 3. Jiang K., Liu M., Lin G., Mao B., Cheng W., Liu H., Gal J., Zhu H., Yuan Z., Deng W., Liu Q., Gong P., Bi X. *, Meng S. * Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death. Oncotarget. 2016. 7 (18): 25652-25667. IF 5.0 4. Qian X., Wang P., Xia Y., Dou T., Jin Q., Wang D., Hao D., Bi X. *, Ge G. *, Yang L.* A highly selective fluorescent probe for sensing activities of catechol-O-methyltransferase in complex biological samples. Sensors and Actuators B. 2016. 231:615–623. IF 4.8 5. Chen H., Wang B., Feng W., Du W., Ouyang H., Chai Z., Bi X.* Oral Magnetite Nanoparticles Disturb the Development of Drosophila Melanogaster from Oogenesis to Adult Emergence. Nanotoxicology. 2015. 9(3):302-312. IF 7.9 6. Yuan Q., Han J., Cong W., Ge Y., Ma D., Dai Z., Li Y., Bi X. * Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with improved cell apoptosis and gene expression profile and reduced myelosuppression toxicity. International Journal of Nanomedicine. 2014. 9(1): 4829-4846. IF 4.3 7. Fang G., Zhang D., Yin H., Zheng L., Bi X.*, Yuan L.* Centlein maintains centrosome cohesion by bridging an interaction between C-Nap1 and Cep68. Journal of Cell Science. 2014. 127:1631-1639. IF 5.4 8. Wang Y., Wang Z., Joshi BH., Puri R., Stultz B., Yuan Q., Bai Y., Zhou P., Yuan Z., Hursh DA., Bi X.* The tumor suppressor Caliban regulates DNA damage induced apoptosis through p53-dependent and –independent activity. Oncogene. 2013. 32(33):3857-66. IF 8.6 9. Liu W., Jiang F., Bi X.*, Zhang Q*. Drosophila FMRP participates in DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. Human Molecular Genetics. 2012, 21(21):4655-68. IF 7.7 10. Kong L., Yuan Y., Zhu H., Li Y., Guo Q., Zhao Y., Wang Q., Bi X.*, Gao X*. The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis. Biomaterials. 2011.32(27)：6515-6522. IF 7.6 11. Wang P., Bai Y., Song B., Wang Y., Liu D., Lai Y., Bi X.*, Yuan Z*. PP1A-mediated dephosphorylation positively regulates YAP2 activity. PLoS ONE. 2011.6(9):e24288. IF 4.3 12. Gao G., Bi X., Chen J., Srikanta D., Rong YS. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. Proc. Nat. Acad. Sci. USA. 2009. 106(26): 10728–10733.(Equal contribution). IF 9.4 13. Bi X., Jones T., Abbasi F., Lee H., Stultz B., Hursh D., Mortin M. Drosophila Caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Oncogene. 2005. 24:8229-8239. IF 6.8 14. Bi X., Srikanta D., Fanti L., Pimpinelli S., Badugu R., Kellum R., Rong Y.S. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proc. Nat. Acad. Sci. USA. 2005. 102(42):15167-15172. IF 10.2 15. Bi X., Gong M., Srikanta D., Rong Y.S. Drophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation. Genetics. 2005. 171:845-847. IF 4.4 16. Bi X., Wei S.D., Rong Y.S. Telomere protection without a telomerase: the role of ATM and Mre11 in Drosophila telomere maintenance. Current Biology. 2004. 14:1348-1353. IF 11.9 17. Bi X., Kajava A., Demidenko Z., Jones T., Mortin M. The carboxyl terminus of Prospero regulates its subcellular localization. Molecular and Cellular Biology. 2003. 23 (3): 1014-1024. IF 8.9