导师姓名：杨蕾
性别：女
人气指数：255

所属院校：中国药科大学
所属院系：中药学院
职称：副教授
导师类型：
招生专业：药学（天然药物化学）、中药学（中药化学）
研究领域： 天然产物的高通量药物筛选体系的建立、中药及天然药物的活性成分和机制研究、基于生物酶反应的生... [展开]


研究领域： 天然产物的高通量药物筛选体系的建立、中药及天然药物的活性成分和机制研究、基于生物酶反应的生物转化研究。 [收起]




通讯方式 :
办公电话：**
电子邮件：dorothy**@163.com
通讯地址：南京市童家巷24号，中国药科大学天然药物化学教研室，邮编210009


个人简述 :
杨蕾，女，博士，1980年5月生，中国药科大学天然药物化学教研室副教授。主要承担本科生天然药物化学课程、研究生天然物结构化学课程的教学工作。2003年中国药科大学生物技术专业本科毕业。2008年中国药科大学微生物与生化药学博士毕业，导师吴梧桐教授。2011年中国药科大学中药学院博士后出站，导师孔令义教授。

科研工作 :
近期代表性论文：· Geng, Y.D., Yang, L. (Co-first author), Zhang, C., Kong, L.Y. 2014. Blockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells. Food Chem. Toxicol. 73. 7-16.· Hu, S.M., Luo, J., Yang, L. (co-corresponding author), Kong, L.Y. 2014.Exploration of possible biosynthetic origin of 1/8/9-orthoester moiety in phragmalins. Tetrahedron Letters. 55, 815-817.· Wu, L., Luo, J., Zhang, Y., Wang, X., Yang, L. (co-corresponding author), Kong, L.Y. 2014. Cassane-type diterpenoids from the seed kernels of Caesalpinia bonduc. Fitoterapia. 93, 201-208.· Zhang, C., Yang, L., Wang, X.B., Wang, J.S., Geng, Y.D., Yang, C.S., Kong, L.Y. 2013. Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells. Cancer Lett. 340, 51-62.· Guo, C., Wang, J.S., Zhang, Y., Yang, L., Wang, P.R., Kong L.Y. 2012. Relationship of chemical structure to in vitro anti-inflammatory activity of tirucallane triterpenoids from the stem barks of Aphanamixis grandifolia. Chem Pharm Bull. 60, 1003-1010.· Yang, L., Wei, D.D., Chen, Z., Wang, J.S., Kong, L.Y. 2011. Reversal of multidrug resistance in human breast cancer cells by Curcuma wenyujin and Chrysanthemum indicum. Phytomedicine. 18, 710-718.· Yang, L., Wei, D.D, Chen, Z., Wang, J.S., Kong, L.Y. 2011. Reversal effects of traditional Chinese herbs on multidrug resistance in cancer cells. Nat Prod Res. 25, 1885-1889.· Yang, L., Jiang, C., Liu, F., You, Q.D., Wu, W.T. 2008. Cloning, enzyme characterization of recombinant human Eg5 and the development of a new inhibitor. Biol Pharm Bull. 31, 1397-1402.· Jiang, C., Yang, L. (Co-first author), Wu, W.T., Guo, Q.L., You, Q.D. 2011. CPUYJ039, a newly synthesized benzimidazole-based compound, is proved to be a novel inducer of apoptosis in HCT116 cells with potent KSP inhibitory activity. J Pharm Pharmacol. 63, 1462-1469.· Jiang, C., Yang, L., Wu, W.T., Guo, Q.L., You, Q.D. 2011. De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. Bioorg Med Chem. 19, 5612-5627.· Fu, R.G., You, Q.D., Yang, L., Wu, W.T., Jiang, C., Xu, X.L. 2010. Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. Bioorg Med Chem. 18, 8035-8043.· Liu, F., Yu, L.Q., Jiang, C., Yang, L., Wu, W.T., You, Q.D. 2010. Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. Bioorg Med Chem. 18, 4167-4177.· Jiang, C., You, Q., Liu, F., Wu, W., Guo, Q., Chern, J., Yang, L., Chen, M. 2009. Design, synthesis and evaluation of tetrahydroisoquinolines as new kinesin spindle protein inhibitors. Chem Pharm Bull. 57, 567-71.· 杨蕾，江程，刘飞，尤启冬，吴梧桐*。Eg5抑制剂体外高通量筛选。药物生物技术。2008；15（6）：418－424。