导师姓名：周向东
性别：男
人气指数：254

所属院校：海南医学院
所属院系：临床学院
职称：
导师类型：硕导
招生专业：内科学
研究领域： 慢性气道炎症
研究领域： 慢性气道炎症 [收起]




个人简述 :
1984.08-1988.08 南京军医院 教员
1994.10-2001.04 大坪医院呼吸内科副主任 副教授/副主任医师
2001.04-2015.06 重医附二院呼吸内科科主任 教授/主任医师
2015.06-至今 海南医学院附属医院呼吸内科科主任 教授/主任医师 1997年始任硕士生导师，2003年任博士生导师，已培养毕业博士生9届、硕士生13届，并和法国巴黎第五大学和俄罗斯医学科学院联合培养博士研究生，培养毕业了多名市级优秀博士研究生。



科研工作 :
1. Li Q, Zhou XD(通讯作者), Nie XH, Yang J. The role of recombinant human elafin in the resistance of A549 cells against Pseudomonas aeruginosa biofilm.Respiration. 2010,79(1):68-75.
2. Li Q, Zhou XD(通讯作者), Xu XY, Yang J. Recombinant human elafin protects airway epithelium integrity during inflammation.Mol Biol Rep. 2010,37(6): 2981-88.
3. Li Q, Zhou XD(通讯作者), Yu HM, Nie XH, Xu XY. Regulation of neutrophil elastase -Induced MUC5AC expression by nuclear factor erythroid-2 related factor 2 in human airway epithelial cells.Journal of Invest Med. 2010, 58(5): 730-36.
4. Li Q, Kolosov VP, Perelman JM, Zhou XD(通讯作者). Src-JNK Dependent pathway in cigarette smoke-induced mucous hypersecretion in airway epithelial Cells.Biologicheskie Membrany. 2010,27(5): 413-23.
5. Li Q, Zhou XD(通讯作者), Yu HM, Nie XH, Xu XY. Roles of ROS/TACE in neutrophil elastase-induced mucus hypersecretion in NCI-H292 airway epithelial cells.Eur Cyto Net. 2010, 21(3):177-85.
6. Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Nicotine suppress inflammatory factors in 16HBE airway epithelial cells responses to cigarette smoke extract and lipopolysaccharide.Translational Research. 2010, 156(6): 326-34.
7. Yang J, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Naringenin Attenuates Mucous Hypersecretion by Modulating Reactive Oxygen Species Production and Inhibiting NF-κB Activity via EGFR-PI3K-Akt/ERK MAPKinase Signaling in Human Airway Epithelial Cells.Mol Cell Biochem. 2011,351:29-40.
8. Yu HM, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Interleukin-13 induces mucin5AC production involving STAT6/SPDEF in human airway epithelial cells. Cell Communication & Adhesion. 2011,17(4-6):83-92.
9. Yu HM, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Role of hyaluronan and CD44 in reactive oxygen species-induced mucus hypersecretion.Mol Cell Biochem. 2011,352:65-75.
10. Yu HM, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Regulation of cigarette smoke-induced mucin expression by neuregulin/ErbB3 signaling in human airway epithelial cells.Basic & Clinical Pharmacology & Toxicology. 2011,109:63-72.
11. Yu HM, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways.Journal of Applied Toxicology. 2012 ,32(4):282-92.
12. Wu HQ, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Theaflavins extracted from black tea inhibit airway mucous hypersecretion induced by cigarette smoke in rats. Inflammation. 2012,35(1):271-9.
13. Jiang DP, Li Q, Perelman JM, Zhou XD(通讯作者). Effects of Scutellarin on MUC5AC Mucin Production Induced by Human Neutrophil Elastase or Interleukin 13 on Airway Epithelial Cells.Journal of Korean Medical Science. 2011,26:778-84.
14. Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Nicotine reduces TNF-α expression through a α7 nAChR/MyD88/NF-κB Pathway in HBE16 airway epithelial cells.Cell Physiol Biochem. 2011,27:605-12.
15. Li MC, Li Q, Yang G, Kolosov VP, Perelman JM, Zhou XD(通讯作者). Cold temperature induces mucin hypersecretion from normal human bronchial epithelial cells in vitro through a transient receptor potential melastatin 8 (TRPM8)-mediated mechanism.J Allergy Clin Immunol. **:626-34.
16. Li N, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Chronic mechanical stress induces mucin5AC expression in human bronchial epithelial cells through ERK dependent pathways.Mol Biol Rep. 2012 ,39(2):1019-28.
17. Zhong T, Perelman JM, Kolosov VP, Zhou XD(通讯作者). MiR-146a modulates neutrophil elastase-induced MUC5AC secretion from 16HBE human bronchial epithelial cells.Mol Cell Biochem. 2011,358:249-255.
18. Yu HM, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Transient receptor potential vanilloid 1 receptors mediate acid-induced mucin secretion via Ca2+ influx in human airway epithelial cells.J Biochem Molecular Toxicology. 2012, 26(5):179-86
19. Li Q, Lei RX,Zhou XD(通讯作者),Perelman JM, Kolosov VP. Regulation of PMA-induced MUC5AC expression by heparin in human bronchial epithelial cells.Mol Cell Biochem. 2012 ,360(1-2):383-91
20. Jiang DP, Li Q, Perelman JM, Zhou XD(通讯作者). Scutellarin attenuate human neutrophil elastase-induced mucus production by inhibiting the PKC-ERK signaling pathway in Vitro and in Vivo.The American Journal of Chinese Medicine, 2011,39(6): 1-14
21. Jiang DP, Li Q, Kolosov VP, Zhou XD(通讯作者). The inhibition of aldose reductase on mucus production induced by interleukin-13 in the human bronchial epithelial cells.Int Immunopharmacol.2012,12(4):588-93
22. Wang XL, Li Q, Zhou XD(通讯作者). Triiodothyronine represses MUC5AC expression by antagonizing Sp1 binding to its promoter in human bronchial epithelial HBE16 cells Journal of Biomedicine and Biotechnology. 2012,2012:648170-9
23. Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM.The expression and pharmacological characterization of nicotinic acetylcholine receptor subunits in HBE16 airway epithelial cells.Cell Biochem Biophys. 2012,42(3):421-31
24. Yu H, Zhou X(通讯作者), Wen S, Xiao Q. Flagellin/TLR5 responses induce mucus hypersecretion by activating EGFR via an epithelial cell signaling cascades.Exp Cell Res.2012,318(6):723-31
25. Li N, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. The effect of quercetin on human neutrophil elastase- induced mucin5AC expression in human airway epithelial cells.Int Immunopharmacol. 2012,14(2):195-201
26. Yang J, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Study of TRPV1-mediated mechanism for the hypersecretion of mucus in respiratory inflammation.Mol Immunol. 2013,53(1-2):161-171
27. Yu HM, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Regulation of particulate matter-induced mucin secretion by transient receptor potential vanilloid 1 receptors.Inflammation.2012,35 (6):1851-9
28. Zhou XD(通讯作者),Tu J, Li Q, Kolosov VP, Perelman JM Hypoxia induces mucin expression and secretion in human bronchial epithelial cells.
Translational Research. 2012,160(6):419-27
29. Liu CY, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM.Regulator of G-protein signaling 2 inhibits acid-induced mucin5AC hypersecretion in human airway epithelial cells.Respiratory Physiology & Neurobiology,2013,185(2):265-71
30. Zhou J, Perelman JM, Kolosov VP, Zhou XD(通讯作者). Neutrophil elastase induces MUC5AC secretion via proteaseactivated receptor. Mol Cell Biochem.2013,377(1):75-85
31. Liu CY, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. The Type 1 Insulin-Like Growth Factor Receptor mediated the hypersecretion of mucus in human airway epithelial Cells.Archives of Biochemistry and Biophysics. 2013,235(2):234-40
32. Xu R, Li Q, Zhou XD(通讯作者), Perelman JM, Kolosov VP. Oxidative stress mediates the disruption of airway epithelial tight-junctions through a TRPM2-PLCγ1-PKCα signalling pathway.Int J Mol Sci 2013, 2914(5):9475-86
33. Liu CY, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Rhythmic pressure waves induce mucin5AC expression via an EGFR-rediated signaling pathway in human airway epithelial cells.DNA Cell Biol. 2013,32(8):423-9
34. Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM.Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation.
International Journal of Molecular Medicine.2013, 32(8):637-46
35. Xu R, Li Q, Zhou XD(通讯作者), Perelman JM, Kolosov VP. Annexin II mediates the neutrophil elastase-stimulated exocytosis of mucin5AC
Molecular Medicine Reports 2014,9(1):299-304
36. Liu C, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. The chitinase-like protein YKL-40 increases mucin5AC production in human bronchial epithelial cells.Experimental Cell Research 2013,319(18):2866-73
37. Li MC, Yang G, Kolosov VP, Perelman JM, Zhou XD(通讯作者).The pathophysiologic mechansms of mucin hypersecretion induced by cold temperatures in cigarette smoke-exposed rats.International Journal of Molecular Medicine. 2014,33(1):83-90
38. Xu R, Li Q, Zhou XD(通讯作者), Perelman JM, Kolosov VP. The Degradation of Airway Tight Junction Protein Under Acidic Conditions is Probably Mediated by Transient Receptor Potential Vanilloid 1 Receptor.Bioscience Reports 2013,3(5):78-86
39. Tong J, Zhou XD(通讯作者), Perelman JM, Kolosov VP. Effect of epithelium ATP release on cyclic pressure-induced airway mucus secretion. Bioscience Reports 2013(Epub)
40. Tong J, Zhou XD(通讯作者), Perelman JM, Kolosov VP. Role of the JNK pathway on the expression of inflammatory factors in alveolar macrophages under mechanical ventilation.International Immunopharmacology 2013,17(3):821-7
41. Liu CY, Li Q, Zhou XD(通讯作者), Kolosov VP, Perelman JM. Cortactin mediates elevated shear stress-induced mucin hypersecretion via actin polymerization in human airway epithelial cells.The International Journal of Biochemistry & Cell Biology. 2013,45(12):2756-63
42. Xu R, Li Q, Zhou XD(通讯作者), Perelman JM, Kolosov VP.Secretoneurin induces airway mucus hypersecretion by enhancing the binding of EGF to NRP1.Cellular Physiology and Biochemistry 2014,44(2):446-56
43. Zhang T, Zhou XD(通讯作者). The Clinical Application of Expectorant Therapy in Chronic Inflammatory Airway Diseases. Experimental and Therapeutic Medicine2014,7(4):763-7
44. Zhang T,Zhou XD(通讯作者),Perelman JM,Kolosov VP. Effects of ATP Release on Mucin5AC Secretion in Airway Epithelial Cells by Mechanical StretchingAnn Clin Lab Sci. 2014 Fall44(4):425-30.
45.Liu XY, Zhou XD(通讯作者). Effect of Wnt/beta-catenin and NF-kappa B Signaling Pathways on Mucus Secretion with Hypertonicity in 16HBE Cells
Brazilian Archives of Biology and Technology, 2013,56(4):567-74
46. Li Q, Li N, Liu CY, Xu R, Kolosov VP, Perelman JM, Zhou XD(通讯作者). Ezrin/Exocyst Complex Regulates Mucin 5AC Secretion Induced by Neutrophil Elastase in Human Airway Epithelial Cells.Cell Physiol Biochem. 201535(1):326-38
47. He ZC, Li SJ, Zhou XD. Rapid identification and detection of intracellular survival testing of mycobacterium smegmatis mc2155 that contains eis gene from mycobacterium tuberculosis by flow cytometry.Curr Microbiol 2011,42(6) :426-32
48. Jia B, Lu P, Huang W, Li C, Huang A, Zhou X, Zhang W, Wu G, Zhang G..A multicenter, randomized controlled clinical study on biapenem and imipenem/cilastatin injection in the treatment of respiratory and urinary tract infections. Chemotherapy. 201056(4):285-90. 49. 杨红菊，尤列.皮尔曼, 维克多.科罗索夫, 周向东(通讯作者).钙敏感受体在缺氧诱导气道黏液高分泌中的作用.中华医学杂志,2014,94(12):944-8.
50. 王鹏,皮尔曼, 维克多.科罗索夫, 周向东(通讯作者). 气道剪应力作用下黏蛋白5AC胞外极向分泌的主要介导因子.中华医学杂志,2013,93(32):2275-81
51. 童瑾,尤列.皮尔曼, 维克多.科罗索夫, 周向东(通讯作者). 甘草酸对白介素13诱导的大鼠黏液高分泌的作用.中华医学杂志,2013,93(28):2225-8
52. 许瑞, 李琪, 尤列.皮尔曼, 维克多.科罗索夫, 周向东(通讯作者). 丙烯醛调控糖皮质激素受体SUMO化水平对气道黏液高分泌的影响.中华医学杂志,2012,92(46):3291-5
53. 江德鹏, 尤列.皮尔曼, 维克多.科罗索夫, 周向东(通讯作者). 携分泌型白细胞蛋白酶抑制因子的间充质干细胞对慢阻肺大鼠的治疗作用.中华医学杂志,2011,91(48):3438-41.
54. 周佳, 尤列.皮尔曼, 维克多.科罗索夫, 周向东(通讯作者). 神经调节蛋白-1在白介素-1所致气道黏液高分泌中的作用.中华医学杂志,2012,92(28),1988-91.
55. 李敏超, 尤列.皮尔曼, 维克多.科罗索夫, 周向东(通讯作者). 冷空气联合香烟烟雾吸入诱导大鼠气道黏液高分泌的机制.中华医学杂志,2012,92(32),2283-7
56. 钟甜, 尤列.皮尔曼, 维克多.科罗索夫, 周向东(通讯作者). 张力敏感性阳离子通道在机械牵张引起气道黏液高分泌中的作用.中华医学杂志,2010,90(33):2328-34.
57. 余红梅, 李琪, 尤列.皮尔曼, 维克多.科罗索夫, 周向东(通讯作者). 鞘氨醇激1对TNF-a诱导的气道黏蛋白 5AC 的调节作用.中华医学杂志,2011,91(6),391-5.
58. 涂静, 尤列o皮尔曼, 维克多o科罗索夫, 周向东(通讯作者). 渗透压反应增强子结合蛋白对高渗下人气道上皮细胞黏液分泌的影响.中华医学杂志,2011,91(8):549-53.
59. 罗琳, 尤列.皮尔曼, 维克多.科罗索夫, 周向东(通讯作者). 阿奇霉素通过基质金属蛋白酶-9抑制气道黏液高分泌的研究.中华医学杂志,2011,91(10):689-93.
60. 李琪, 周向东 (通讯作者). 中性粒细胞弹力蛋白酶引起黏蛋白5AC高表达的信号转导机制. 中华医学杂志,2007, 85 (5):348-52.
61. 徐晓艳, 元东明, 周向东(通讯作者). 重组人Elafin转染气道上皮细胞对脂多糖致气道黏液高分泌的影响.中华医学杂志,2011,91(5):340-4.
62. 周治宇，张婷，周向东. 热休克蛋白70在气道粘液高分泌的作用及机制.中华医学杂志,2015,95(8):581-4
63. 李琪, 周向东 (通讯作者). c-Src/Nox1/活性氧对中兴粒细胞弹力蛋白酶诱导气道黏蛋白5AC表达的影响.中华结核和呼吸杂志,2010, 33(1):46-50.
64. 邬海桥, 李琪, 周向东 (通讯作者). 茶黄素和表皮生长因子受体对气道黏液分泌影响. 中华结核和呼吸杂志,2009, 32 (1):27-32.
65. 余红梅, 李琪, 尤列.皮尔曼, 维克多.科罗索夫, 周向东(通讯作者). 内生多肽Elafin对气道黏蛋白5AC表达的影响.中华结核和呼吸杂志,2010,33(11):801-5.
66. 李敏超, 尤列.皮尔曼, 维克多.科罗索夫, 周向东(通讯作者). 瞬时受体电位M8通道对冷刺激诱导气道上皮细胞炎症反应的影响.中华结核和呼吸杂志,2011,34(10):757-61
67. 周向东, 兰箭, 张婷. 对结核性胸膜炎患者使用分支杆菌类免疫刺激剂的商榷性研究中华结核呼吸杂志, 2002, 25(10):595.
68. 周向东, 李升锦, 王导新. 慢性阻塞性肺疾病患者机械通气时气道滴灌液的研究.中华结核和呼吸杂志,2002,25(8):511.
69. 周向东, 童瑾, 兰箭. 慢性阻塞性肺疾病患者气道粘蛋白分子表型的研究.中华结核和呼吸杂志,2002, 25(7):437.
70. 周向东, 杨肇亨, 龙勉. 嗜酸细胞活化过程细胞粘附性改变的单细胞定量研究.中华结核和呼吸杂志,1996,19(3):147-8.
71. 周向东, 黄勇. 糖皮质激素对肺部炎性效应细胞凋亡作用的异质性.中华结核和呼吸杂志,1998,21(4):224-6.
72. 黄勇, 扬肇亨, 周向东. 孟鲁司特对慢性支气管炎大鼠气道粘蛋白高分泌的抑制作用. 中华结核和呼吸杂志 2001,24(10):637.
73. 曹国强, 杨肇亨, 周向东.　E-选择素mRNA在哮喘豚鼠支气管组织中的原位表达.中华结核与呼吸病杂志,1998,21(1).
74. 张桂蓉,罗永艾, 梅同华,周向东.非小细胞肺癌组织中血管内皮生长因子、CD44及Ki67的表达水平及与患者预后的关系.中华结核和呼吸杂志,2003,26(7):444
75. 周向东, 阳涛. 抗生素杀菌过程致内毒素释放的比较性研究.中华内科杂志,1998,37(10):686-8.
76. 周向东, 杨肇亨, 黄勇. 急性肺损伤时肺血管床中性粒细胞滞留的分子基础研究.中华内科杂志,1996,35(8):556.
77. 聂晓红, 周向东 (通讯作者). Elafin重组气道上皮细胞对铜绿假单胞菌生物被膜的抗菌作用.中华微生物学和免疫学杂志, 2006, 29 (8):722.
78. 周向东, 童谨, 梅同华. 胆碱能拮抗剂对老年人慢性阻塞性肺疾病气道黏液的调控.中华老年医学杂志2002,21(5)382.
79. 周向东, 李升锦, 杜先智. 呼吸道组织振荡技术对气道滞留物清除的影响.中华物理医学与康复杂志,2002,24(7):396-8.
80. 陈贵华, 周向东(通讯作者),李琪,刘益群. 康复治疗改善慢性阻塞性肺疾病患者的生活质量和肺功能. 中华物理医学与康复杂志,2012,34(6):444-7.
81. 应少聪,周向东(通讯作者) 刘益群，康复训练结合健康教育对老年慢性阻塞性肺疾病患者生活质量及其心理健康状况的影响.中华物理医学与康复杂志,2014,36(5):333-6
82. 周向东, 杨肇亨. 内毒素致肺血管内皮细胞粘附中性粒细胞增加的机理研究.中华创伤杂志,1996,12(2)116-8.
83. 周向东, 黄勇. 大环内酯抗生素促进急性肺损伤组织中性粒细胞凋亡的研究.中华创伤杂志1998,14(3):160-2.
84. 周向东, 刘明一. 急性肺损伤组织对^99mTc-PMN滞留能力的活体示踪观察.中华核医学杂志,1996,16(2):131.
85. 周向东, 张太和, 周晓军, 赵慧玲,史勤. 实验性肝硬化时心钠素改变的血清学,免疫金银染色和免疫电镜的定量研究.中华消化杂志,1993,13(2):124-6
86. 周向东, 张太和, 周晓军. 肝硬化大鼠心脏心钠素改变的形态定量研究.中华病理杂志,1993,13(3):185-6
87. 聂晓红, 周向东(通讯作者). 强力素重组气道上皮细胞对铜绿假单胞菌生物膜抵御作用.中华医院感染学杂志, 2009,11 (3):26-9.
88. 周向东, 童 瑾, 梅同华. 多形核中性粒细胞对大环内酯抗生素内在化的特殊意义.中华医院感染学杂志,2003,13(12):1101-03.
89. 陈雪梅, 周向东(通讯作者). 不同抗生素杀菌过程导致细菌内毒素释放的异质性.中华医院感染学杂志 1999,9(1):19-21.


教育背景 :
1979.08-1984.07 第二军医大学临床医学系 本科
1988.08-1991.07 第二军医大学分子病理学专业 硕士
1991.08-1994.08 第三军医大学分子病理学专业 博士
2005.10-2006.08 香港大学医学院进修临床医学