导师姓名：唐朝克
性别：男
人气指数：864

所属院校：南华大学
所属院系：医学院
职称：教授
导师类型：
招生专业：基础医学


通讯方式 :
办公电话：**
电子邮件：tangchaoke@qq.com
通讯地址：南华大学医学研究中心


个人简述 :
(1) 唐朝克（1/6）, ABCA1 介导抗炎的新功能及其分子机制研究. 湖南省人民政府，湖南省自然科学, 二等奖，2014年，证书编号：**-Z1-219-R01. (唐朝克, 尹凯, 莫中成, 赵国军, 欧阳新平, 吕运成)(2) 唐朝克（1/6）以ABCAl为靶点防治动脉粥样硬化发生发展. 湖南省人民政府，湖南省自然科学, 三等奖，2012.（唐朝克, 廖端芳, 尹卫东, 杨永宗, 莫中成, 易光辉）证书编号：**-Z3-219-R01(3) 唐朝克, 尹凯, 莫中成, 赵国军, 欧阳新平, 吕运成, 唐雅玲. ABCA1 介导抗炎的新功能及其分子机制研究. 2014年度2014年衡阳市科学技术进步二等奖. 证书编号：2013KJ18-1.(4) 唐朝克, 廖端芳, 尹卫东, 杨永宗, 王佐, 易光辉, 袁中华, 危当恒, 唐雅玲. 以ABCAl为靶点防治动脉粥样硬化发生发展. 2008年度湖南医学科技二等奖，证书编号：**(5) 王宗保, 尹卫东, 唐朝克, 席守民, 易光辉、刘录山. NO-1886调节糖代谢和脂代谢的作用及机制. 2005年度湖南省科技进步三等奖. 证书编号：**.(6) 中国病理生理学会动脉粥样硬化专业委员会常务委员（2015-2019） (7) 国际动脉粥样硬化学会中国分会常委理事（2015-2019）(8) 湖南省生理科学会第十一届理事会常委理事兼副秘书长（2015-2019） (9) 2009年起为湖南省病理生理学心血管专业委员会委员

科研工作 :
2004.09-至今 南华大学心血管病研究所 二级教授、博导2000.09-2004.08 南华大学心血管病研究所 副教授1981.07-2000.08 衡阳医学院生理和诊断教研室 教师一、近5年发表的SCI收录论文 期 刊->Yao Y（#）, Zhang X, Chen HP, Li L, Xie W, Lan G, Zhao ZW, Zheng XL, Wang ZB（*）, Tang CK（*）. MicroRNA-186 promotes macrophage lipid accumulation and secretion of pro-inflammatory cytokines by targeting cystathionine γ-lyase in THP-1 macrophages. Atherosclerosis. 2016, 250: 122-132. (IF: 3.942). 期 刊->Lv YC（#）, Tang YY（#）, Zhang P, Wan W, Yao F, He PP, Xie W, Mo ZC, Shi JF, Wu JF, Peng J, Liu D, Cayabyab FS, Zheng XL, Tang XY, Ouyang XP（*）, Tang CK（*）. Histone Methyltransferase Enhancer of Zeste Homolog 2-Mediated ABCA1 Promoter DNA Methylation Contributes to the Progression of Atherosclerosis. PLoS One. 2016, 11(6): e**. (IF: 3.057)期 刊->Xie W（#）, Li L（#）, Zhang M（#）, Cheng HP, Gong D, Lv YC, Yao F, He PP, Ouyang XP, Lan G, Liu D, Zhao ZW, Tan YL, Zheng XL, Yin WD（*）, Tang CK（*）. MicroRNA-27 Prevents Atherosclerosis by Suppressing Lipoprotein Lipase-Induced Lipid Accumulation and Inflammatory Response in Apolipoprotein E Knockout Mice. PLoS One. 2016, 11(6): e**. (IF: 3.057)期 刊->Zhang M（#）, Li L（#）, Xie W（#）, Wu JF, Yao F, Tan YL, Xia XD, Liu XY, Liu D, Lan G, Zeng MY, Gong D, Cheng HP, Huang C, Zhao ZW, Zheng XL, Tang CK（*）. Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation. Atherosclerosis. 2016, 248: 149-159. (IF: 3.942)期 刊->Gong D（#）, Chen HP, Xie W, Zhang M, Liu D, Lan G, Huang C, Zhao ZW, Chen LY, Yao F, Tan YL, Li L, Xia XD, Zheng XL, Wang ZB（*）, Tang CK（*）. Cystathionine γ-Lyase(CSE)/Hydrogen Sulfide System Is Regulated by miR-216a and Influences Cholesterol Efflux in Macrophages via the PI3K/AKT/ABCA1 pathway. Biochem Biophys Res Commun. 2016, 470(1):107-16. (IF: 2.371). 期 刊->Peng L（#）, Zhang Z（#）, Zhang M（#）, Yu X, Yao F, Tan Y, Liu D, Gong D, Chong H, Liu X, Zheng X, Tian G（*）, Tang C（*）. Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/NF-кB/ZNF202 pathway in THP-1 macrophages. Acta Biochim Biophys Sin (Shanghai). 2016, 48(4):363-70. (IF: 2.124)期 刊->Li L（#）, Xie W（#）, Zheng XL, Yin WD（*）, Tang CK（*）. A novel peptide adropin in cardiovascular diseases. Clin Chim Acta. 2016, 453:107-113. (IF: 2.799)期 刊->Liu D, Zhang M, Xie W, Lan G, Cheng HP, Gong D, Huang C, Lv YC, Yao F, Tan YL, Li L, Zheng XL, Tang CK（*）. MiR-486 Regulates Cholesterol Efflux by Targeting HAT1. Biochem Biophys Res Commun. 2016, 472(3):418-24. (IF: 2.371).期 刊->Lan G（#）, Xie W, Li L, Zhang M, Liu D, Tan YL, Cheng HP, Gong D, Huang C, Zheng XL, Yin WD（*）, Tang CK（*）. MicroRNA-134 Actives lipoprotein lipase-mediated Lipid Accumulation and Inflammatory Response by Targeting Angiopoietin-Like 4 in THP-1 Macrophages. Biochem Biophys Res Commun. 2016, 472(3):410-7. (IF: 2.371).期 刊->Lv YC（#）, Yang J（#）, Yao F（#）, Xie W, Tang YY, Ouyang XP, He PP, Tan YL, Li L, Zhang M, Liu D, Cayabyab FS, Zheng XL, Tang CK（*）. Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1. Atherosclerosis. 2015, 240(1): 80-89. (IF: 3.942). 期 刊->He PP（#）, OuYang XP（#）, Li Y, Lv YC, Wang ZB, Yao F, Xie W, Tan YL, Li L, Zhang M, Lan G, Gong D, Cheng HP, Zhong HJ, Liu D, Huang C, Li ZX, Zheng XL, Yin WD（*）, Tang CK（*）.MicroRNA-590 Inhibits Lipoprotein Lipase Expression and Prevents Atherosclerosis in apoE Knockout Mice. PLoS One. 2015, 10(9): e**. (IF: 3.057)期 刊->Peng J（#）, Lv YC, He PP, Tang YY, Xie W, Liu XY, Li Y, Lan G, Zhang M, Zhang C, Shi JF, Zheng XL, Yin WD（*）, Tang CK（*）. Betulinic Acid Downregulates Expression of Oxidative Stress-Induced Lipoprotein Lipase via the PKC/ERK/c-Fos Pathway in RAW264.7 Macrophages. Biochimie. 2015, 119: 192-203. (IF: 2.474)期 刊->Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK（*）. Apelin-13 Impedes Foam Cell Formation by Activating Class III PI3K/Beclin-1-Mediated Autophagic Pathway. Biochem Biophys Res Commun. 2015, 466(4):637-43. (IF: 2.371)期 刊->Yu XH（#）, Zheng XL, Tang CK（*）. Nuclear Factor-κB Activation as a Pathological Mechanism of Lipid Metabolism and Atherosclerosis. Adv Clin Chem. 2015, 70: 1-30. (IF: 2.295).期 刊->Yu XH（#）, Zheng XL, Tang CK（*）. Peroxisome Proliferator-Activated Receptor α in Lipid Metabolism and Atherosclerosis. Adv Clin Chem. 2015, 71: 171-203. (IF: 2.295).期 刊->Tan YL（#）, Zheng XL, Tang CK（*）. The Protective Functions of Omentin in Cardiovascular Diseases. Clin Chim Acta. 2015, 448: 98-106. (IF: 2.799)期 刊->Yu X（#）, Zhang J, Zheng X, Yang Y（*）, Tang CK（*）. Interferon-γ in foam cell formation and progression of atherosclerosis. Clin Chim Acta. 2015, 441: 33-43. (IF: 2.799).期 刊->Li-bao Cui1（#）, Xiao-hua Yu（#）, Chong-hui Jiang, Ya-ling Tang, Xin-Ping Ouyang, Yun-Cheng Lv, Ping-Ping He, Feng Yao, Yan-Yan Tang, Min Zhang, Da-Wei Zhang , Tang CK（*）. Probucol Inhibits Atherosclerosis by Regulating ABCA1, SR-BI, ABCG5 and ABCG8 Expression and Anti-inflammatory Effects in Hypercholesterolemic Rabbits. 生物化学与生物物理学进展. 2015, 42(9):866-876. (IF: 0.224).期 刊->Zhao GJ（#）, Tang SL（#）, Lv YC, Ouyang XP, He PP, Yao F, Tang YY, Zhang M, Tang YL, Tang DP, Cayabyab FS, Tian GP（*）, Tang CK（*）. NF-κB Suppresses the Expression of ATP-binding cassette transporter A1/G1 by Regulating SREBP-2 and miR-33a in Mice. Int J Cardiol. 2014, 171: e93-e95. (IF: 4.036).期 刊->Lv YC（#）, Tang YY（#）, Peng J（#）, Zhao GJ, Yang J, Yao F, Ouyang XP, He PP, Xie W, Tan YL, Zhang M, Liu D, Tang DP, Cayabyab FS, Zheng XL, Zhang DW, Tian GP（*）, Tang CK（*）. MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. Atherosclerosis. 2014, 236(1): 215-226. (IF: 3.994).期 刊->Zhao GJ（#）, Mo ZC（#）, Tang SL, Ouyang XP, He PP, Lv YC, Yao F, Tan YL, Xie W, Shi JF, Wang Y, Zhang M, Liu D, Tang DP, Zheng XL, Tian GP（*）, Tang CK（*）. Chlamydia pneumoniae negatively regulates ABCA1 expression via TLR2-Nuclear factor-kappa B and miR-33 pathways in THP-1 macrophage-derived foam cells. Atherosclerosis. 2014, 235(2): 519–525. (IF: 3.994).期 刊->Zhang M（#）, Wu JF（#）, Chen WJ（#）, Tang SL, Mo ZC, Tang YY, Li Y, Wang JL, Liu XY, Peng J, Chen K, He PP, Lv YC, Ouyang XP, Yao F, Tang DP, Cayabyab FC, Zhang DW, Zheng XL, Tian GP（*）, Tang CK（*）. MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages. Atherosclerosis. 2014, 234(1): 54-64. (IF: 3.994).期 刊->Mo ZC（#）, Xiao J, Tang SL, Ouyang XP, He PP, Lv YC, Long ZF, Yao F, Tan YL, Xie W, Zhang M, Liu D, Tian GP, Tang DP, Zheng XL, Zhao GJ（*）, Tang CK（*）. Advanced Oxidation Protein Products Exacerbates Lipid Accumulation and Atherosclerosis Through Downregulation of ATP-Binding Cassette Transporter A1 and G1 Expression in Apolipoprotein E Knockout Mice. Circ J. 2014, 78(11): 2760-2770. (IF: 3.940).期 刊->He PP（#）, Ouyang XP（#）, Tang YY（#）, Liao L, Wang ZB, Lv YC, Tian GP, Zhao GJ, Huang L, Yao F, Xie W, Tang YL, Chen WJ, Zhang M, Li Y, Wu JF, Peng J, Liu XY, Zheng XL, Yin WD（*）, Tang CK（*）. MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages. Biochimie. 2014, 106(2014): 81-90. (IF: 2.963)期 刊->Li Y, He PP, Zhang DW, Zheng XL, Cayabyab FS, Yin WD（*）, Tang CK（*）. Lipoprotein lipase: from gene to atherosclerosis. Atherosclerosis. 2014 Dec, 237(2): 597-608. (IF: 3.994)期 刊->Fu H（#）, Tang YY（#）, Ouyang XP（#）, Tang SL, Su H, Li X, Huang LP, He M, Lv YC, He PP, Yao F, Tan YL, Xie W, Zhang M, Wu J, Li Y, Chen K, Liu D, Lan G, Zeng MY, Zheng XL, Tang CK（*）. Interleukin-27 inhibits foam cell formation by promoting macrophage ABCA1 expression through JAK2/STAT3 pathway. Biochem Biophys Res Commun. 2014, 452(4): 881-7. (IF: 2.297)期 刊->Wang Y（#）, Wu JF（#）, Tang YY, Zhang M, Li Y, Chen K, Zeng MY, Yao F, Xie W, Zheng XL, Zeng GF（*）, Tang CK（*）. Urotensin II increases foam cell formation by repressing ABCA1 expression through the ERK/NF-κB pathway in THP-1 macrophages. Biochem Biophys Res Commun. 2014, 452(4): 998-1003. (IF: 2.297)期 刊->Wu JF（#）, Wang Y（#）, Zhang M（#）, Tang YY, Wang B, He PP, Lv YC, Ouyang XP, Yao F, Tan YL, Tang SL, Tang DP, Cayabyab FS, Zheng XL, Zhang DW, Zeng GF（*）, Tang CK（*）. Growth differentiation factor-15 induces expression of ATP-binding cassette transporter A1 through PI3K/PKCζ/SP1 pathway in THP-1 macrophages. Biochem Biophys Res Commun. 2014, 444(3): 325-331. (IF: 2.297)期 刊->Tian GP（#）, Tang YY（#）, He PP（#）, Lv YC, Ouyang XP, Zhao GJ, Tang SL, Wu JF, Wang JL, Peng J, Zhang M, Li Y, Cayabyab FS, Zheng XL, Zhang DW, Yin WD（*）, Tang CK（*）. The effects of miR-467b on lipoprotein lipase (LPL) expression, pro-inflammatory cytokine and lipid levels and atherosclerotic lesions in apolipoprotein E knockout mice. Biochem Biophys Res Commun. 2014, 443(2): 428-434. (IF: 2.297)期 刊->Yu XH（#）, Cui LB, Wu K, Zheng XL, Cayabyab FS, Chen ZW（*）, Tang CK（*）. Hydrogen sulfide as a potent cardiovascular protective agent. Clin Chim Acta. 2014, 437: 78-87. (IF: 2.824)期 刊->Yu XH（#）, Jiang N（#）, Zheng XL, Cayabyab FS, Tang ZB（*）, Tang CK（*）. Interleukin-17A in lipid metabolism and atherosclerosis. Clin Chim Acta. 2014, 431: 33-39. (IF: 2.824) 期 刊->Yu XH（#）, Qian K, Jiang N, Zheng XL, Cayabyab FS, Tang CK（*）. ABCG5/ABCG8 in cholesterol excretion and atherosclerosis. Clin Chim Acta. 2014, 428: 82-88. (IF: 2.824)期 刊->Yu XH, Jiang N, Yao PB, Zheng XL, Cayabyab FS, Tang CK（*）. NPC1, intracellular cholesterol trafficking and atherosclerosis. Clin Chim Acta. 2014, 429: 69-75. (IF: 2.824)期 刊->Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP（*）, Tang CK（*）. Apelin and its receptor APJ in cardiovascular diseases. Clin Chim Acta. 2014, 428:1-8. (IF: 2.824)期 刊->Liu XY（#）, Lu Q（#）, Ouyang XP, Tang SL, Zhao GJ, Lv YC, He PP, Kuang HJ, Tang YY, Fu Y, Zhang DW, Tang CK（*）. Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase C α signaling in THP-1 macrophage-derived foam cells. Atherosclerosis. 2013, 226(2):398-407. (IF: 3.917).期 刊->Guo-Jun Zhao（#）, Shi-Lin Tang（#）, Yun-Cheng Lv, Xin-Ping Ouyang, Ping-Ping He, Feng Yao, Wu-Jun Chen, Qian Lu, Yan-Yan Tang, Min Zhang, Yuchang Fu, Da-Wei Zhang, Kai Yin（*）, Tang CK（*）. Antagonism of betulinic acid on LPS-mediated inhibition of ABCA1 and cholesterol efflux through inhibiting nuclear factor-kappaB signaling pathway and miR-33 expression. Plos One, 2013, 8(9): e74782. (IF: 3.534)期 刊->Lu Q（#）, Tang SL（#）, Liu XY, Zhao GJ, Ouyang XP, Lv YC, He PP, Yao F, Chen WJ, Tang YY, Zhang M, Zhang DW, Yin K（*）, Tang CK（*）. Tertiary-Butylhydroquinone Upregulates Expression of ATP-Binding Cassette Transporter A1 via Nuclear Factor E2-Related Factor 2/Heme Oxygenase-1 Signaling in THP-1 Macrophage-Derived Foam Cells. Circ J. 2013, 77(9): 2399-2408. (IF: 3.685). 期 刊->Chen WJ（#）, Zhang M, Zhao GJ, Fu Y, Zhang DW, Zhu HB, Tang CK（*）. MicroRNA-33 in atherosclerosis etiology and pathophysiology. Atherosclerosis. 2013, 227 (2) : 201-208. (IF: 3.917). 期 刊->Yu XH（#）, Fu YC, Zhang DW, Yin K（*）, Tang CK（*）. Foam cells in atherosclerosis. Clin Chim Acta. 2013, 424: 245-252. (IF: 2.764) 期 刊->Lv YC（#）, Yin K, Fu YC, Zhang DW, Chen WJ, Tang CK（*）. Posttranscriptional Regulation of ATP-Binding Cassette Transporter A1 in Lipid Metabolism. DNA Cell Biol. 2013, 32(7): 348-358. (IF: 1.991).期 刊->Yin K（#）, Tang SL（#）, Yu XH（#）, Tu GH, He RF, Li JF, Xie D, Gui QJ, Fu YC, Jiang ZS, Tu J（*）, Tang CK（*）. Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE-/- mice possibly via activated STAT3-mediated upregulation of tristetraprolin. Acta Pharmacol Sin. 2013, 34 (6):837-846. (IF: 2.496).期 刊->Tang SL（#）, Chen WJ（#）, Yin K, Zhao GJ, Mo ZC, Lv YC, Ouyang XP, Yu XH, Kuang HJ, Jiang ZS, Fu YC, Tang CK（*）. PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway. Atherosclerosis. 2012, 222(2): 344-354. (IF: 3.706)期 刊->Tian GP（#）, Chen WJ（#）, He PP（#）, Tang SL, Zhao GJ, Lv YC, Ouyang XP, Yin K, Wang PP, Cheng H, Chen Y, Huang SL, Fu Y, Zhang DW, Yin WD（*）, Tang CK（*）. MicroRNA-467b targets LPL gene in RAW 264.7 macrophages and attenuates lipid accumulation and proinflammatory cytokine secretion. Biochimie. 2012, 94(12):2749-55 (IF: 3.142)期 刊->Yu XH（#）, Jiang HL, Chen WJ, Yin K, Zhao GJ, Mo ZC, Ouyang XP, Lv YC, Jiang ZS, Zhang DW, Tang CK（*）. Interleukin-18 and Interleukin-12 Together Downregulate ATP-Binding Cassette Transporter A1 Expression Through the Interleukin-18R/Nuclear Factor-κB Signaling Pathway in THP-1 Macrophage-Derived Foam Cells. Circulation Journal. 2012, 76(7): 1780-1791. (IF: 3.578)期 刊->Chen WJ（#）, Yin K, Zhao GJ, Fu YC, Tang CK（*）. The magic and mystery of MicroRNA-27 in atherosclerosis. Atherosclerosis. 2012, 222(2): 314-323. (IF: 3.706). 期 刊->Zhao GJ（#）, Yin K, Fu YC, Tang CK（*）. The Interaction of ApoA-I and ABCA1 Triggers Signal Transduction Pathways to Mediate Efflux of Cellular Lipids. Mol Med. 2012, 18(1): 149-158. (IF: 4.469).期 刊->Yin K（#）, Chen WJ, Zhou ZG, Zhao GJ, Lv YC, Ouyang XP, Yu XH, Fu Y, Jiang ZS, Tang CK（*）. Apolipoprotein A-I Inhibits CD40 Proinflammatory Signaling via ATP-Binding Cassette Transporter A1-Mediated Modulation of Lipid Raft in Macrophages. J Atheroscler Thromb. 2012, 19(9):823-36. (IF: 2.933)期 刊->Jiang J（#）, Mo ZC, Yin K, Zhao GJ, Lv YC, Ouyang XP, Jiang ZS, Fu Y, Tang CK（*）. Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells. Int J Mol Med. 2012, 29(5): 946-956. (IF: 1.957).期 刊->Xiao-Hua Yu（#）, Xiao-Xu Li, Guo-Jun Zhao, Ji Xiao, Zhong-Cheng Mo, Kai Yin, Zhi-Sheng Jiang, Yuchang Fu, Xiao-Hui Zha, Tang CK（*）. OxLDL Upregulates Niemann-Pick Type C1 (NPC1) Expression through ERK1/2/COX-2/PPARα Signaling Pathway in Macrophages. Acta Biochim Biophys Sin , 2012，44(2):119-28. (IF:1.807)期 刊->莫中成, 唐朝克. 脂代谢与心血管疾病. 生物化学与生物物理学进展. 2015, 42(9):317-323. (IF: 0.224).期 刊->欧阳新平, 何平平, 唐艳艳,张敏, 李元, 唐朝克（*）. 三磷酸腺苷结合盒转运体A1在脑疾病发生发展中的作用. 生物化学与生物物理学进展. 2014, 40(4):317-323. (IF: 0.324).期 刊->唐艳艳（#）, 陈五军, 路倩, 唐朝克（*）. ABCA1 的胞内运输及功能研究新进展. 生物化学与生物物理学进展. 2013,40(6): 510-519. (IF: 0.29).期 刊->赵国军（#）, 唐朝克（*）. 固有免疫应答与动脉粥样硬化关系的研究进展. 生物化学与生物物理学进展.2013,40(5):406-415. (IF: 0.29).期 刊->张敏（#）, 何平平（#）, 欧阳新平,尹凯（*）, 唐朝克（*）. AIBP介导胆固醇流出调控血管新生. 生物化学与生物物理学进展. 2013, 40(9):813-815. (IF: 0.29).期 刊->刘晓艳（#）, 路倩, 陈五军, 唐朝克（*）. HDL-C水平相关的遗传学研究最新进展. 生物化学与生物物理学进展. 2012, 39(12):1145-1155. (IF: 0.554).期 刊->路倩（#）, 陈五军, 尹凯, 赵国军, 唐朝克（*）. 动脉粥样硬化中胆固醇外流的研究进展.生物化学与生物物理学进展. 2012, 39(4): 319-326 (IF: 0.554).(1) HAT1促进ABCA1核心组蛋白乙酰化在动脉粥样硬化中的作用及miR-486靶向调控机制. 2015年国家自然科学基金资助项目（主持, No：**）, 2016年-2019年, 57万元.(2) HSP70通过JNK/Elk-1信号通路抑制ABCA1表达和RCT效率. 2015年湖南省科技厅创新平台与人才计划（应用基础研究）资助项目（主持, No：2015JC3082），2015年-2016年，5万元.(3) ABCA1甲基化在动脉粥样硬化中的作用及miR-155靶向调控机制. 2013年国家自然科学基金资助项目（主持, No：**）, 2014年-2017年, 70万元. (4) MiR-27a/b靶向沉默ABCA1调控胆固醇逆向转运。2011年国家自然科学基金资助项目（主持, NO: **）, 2012年-2015年, 52万元.(5) 以ABCA1为靶点防治动脉粥样硬化的新机制—ABCA1作为膜受体介导抗炎的新功能. 2010年国家自然科学基金资助项目（主持, NO:**）, 2011年-2013年，33万元.(6) ApoA1/ABCA1途径调节巨噬细胞炎症反应及其分子机制研究。2010年湖南省自然科学衡阳联合基金资助项目（主持, NO: 10JJ9019），2010年-2012年，5万元.(7) apoA-I类似肽D-4F对ABCA1的作用及其机制. 南华大学留学回国人员启动基金资助项目，2008年-2010年，5万元.(8) D-4F经PKA信号途径影响ABCA1的表达和功能。南华大学博士后启动基金资助项目，2008年-2010年，3万元.(9) LXR-ABCA1途径在防治动脉粥样硬化中的作用. 湖南省自然科学基金资助项目（主持, NO: 06jj5058），2006年-2008年，2万元.(10) 以肝Ｘ为受体靶点防治动脉粥样硬化发生发展. 中国博士后科学基金资助项目（主持, NO:**），2006年-2007年，2万元.(11) 以ABCA1为靶点防治动脉粥样硬化形成. 2004年国家自然科学基金资助项目（主持, NO: **），2005年-2007年，21万元.

教育背景 :
2006.05-2007.05 加拿大萨斯卡彻温大学 访问学者2004.09-2006.04 重庆大学 博士后2001.09-2004.06 中南大学 医学博士1996.09-1999.07 湖南医科大学 硕士1993.09-1995.07 衡阳医学院 本科