导师姓名：周平坤
性别：男
人气指数：1094

所属院校：南华大学
所属院系：公共卫生学院
职称：研究员
导师类型：
招生专业：卫生毒理学


通讯方式 :
办公电话：**
电子邮件：zhoupkek@aliyun.com
通讯地址：北京市海淀区太平路27号院


个人简述 :
1.放射致基因组损伤效应基础危害评价和防护研究，获中国人民解放军科学技术进步奖一等奖，周平坤为第一完成人，2015年10月。2.2015年获总后二等功，3.亚洲辐射研究协会（AARR）授予“辐射研究杰出贡献奖”2013年5月。

科研工作 :
1985/07-至今军事医学科学院，放射与辐射医学研究所，研究员1998/03-2000/03 法国居里研究所（访问）研究员2013-至今苏州大学，客座教授1.Shi HM, Ding KK, Zhou PK, Guo DM, Chen D, Li YS, Zhao CL, Zhao CC, Zhang X. Radiation-induced expression of IER5 is dose-dependent and not associated with the clinical outcomes of radiotherapy in cervical cancer. Oncol Lett. 2016 Feb11(2):1309-1314. Epub 2016 Jan 82.Liu F, Ren C, Li H, Zhou P, Bo X, Shu W. De novo Identification of replication-timing domains in the human genome by deep learning. Bioinformatics, 2015 Nov 5. pii: btv643.3.Xiong S, Pan X, Xu L, Yang Z, Guo R, Gu Y, Li R, Wang Q, Xiao F, Du L, Zhou P, Zhu M. Regulatory T Cells Promote β-Catenin-Mediated Epithelium-to-Mesenchyme Transition During Radiation-Induced Pulmonary Fibrosis. Int J Radiat Oncol Biol Phys, 2015 Oct 1 93(2):425-35. 4.Song N, Ma X, Li H, Zhang Y, Wang X, Zhou P, Zhang X. microRNA-107 functions as a candidate tumor suppressor gene in renal clear cell carcinoma involving multiple genes. Urol Oncol. 2015 May33(5):205.e1-11.5.Shang ZF, Tan W, Liu XD, Yu L, Li B, Li M, Song M, Wang Y, Xiao BB, Zhong CG, Guan H*, Zhou PK*. DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway. Int J Biol Sci. 2015 Jul 1411(9):1026-35. 6.Cui F, Fan R, Chen Q, He Y, Song M, Shang Z, Zhang S, Zhu W, Cao J, Guan H, Zhou PK*. The involvement of c-Myc in the DNA double-strand break repair via regulating radiation-induced phosphorylation of ATM and DNA-PKcs activity. Mol Cell Biochem. 2015 Aug406(1-2):43-51. 7.Zou LH, Shang ZF*, Tan W, Liu XD, Xu QZ, Song M, Wang Y, Guan H, Zhang SM, Yu L, Zhong CG, Zhou PK*. TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1. Oncotarget. 2015, 6(9): 7011-7022.8.Zhang SM, Shang F, Zhou PK*. Autophagy as the effector and player in DNA damage response of cells to genotoxicants. Toxicology Research, 2015, 4: 613-622 3.2739.Li MJ, Cui F, Cheng Y, Han L, Wang J, Sun D, Liu YL, Zhou PK*, Min R*. Gelsolin: Role of a Functional Protein in Mitigating Radiation Injury. Cell Biochem Biophys, 2015, 71(1): 389-396 2.3810. Zhang SM*, Zhang H, Yang TY, Ying TY, Yang PX, Liu XD, Tang SJ, Zhou PK*. Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination. Int J Biol Sci. 2014 10(10):1138-49. 11.Huang B, Shang ZF, Li B, Wang Y, Liu XD, Zhang SM, Guan H, Rang WQ, Hu JA, Zhou PK*. DNA-PKcs associates with PLK1 and is involved in proper chromosome segregation and cytokinesis. J Cell Biochem. 2014 115(6):1077-88.12.Tu WZ, Li B, Huang B, Wang Y, Liu XD, Guan H, Zhang SM, Tang Y, Rang WQ*, Zhou PK*. γH2AX foci formation in the absence of DNA damage: mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway. FEBS Lett. 2013 587(21):3437-43. 13.Li B, Shang ZF, Yin JJ, Xu QZ, Liu XD, Wang Y, Zhang SM, Guan H, Zhou PK*. PIG3 functions in DNA damage response through regulating DNA-PKcs homeostasis. Int J Biol Sci. 2013 9(4):425-34. 14.Shang ZF, Yu L, Li B, Tu WZ, Wang Y, Liu XD, Guan H, Huang B, Rang WQ, Zhou PK*.4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1. Cell Cycle. 2012 11(18):3463-71.15.Zhang SM, Song M, Yang TY, Fan R, Liu XD, Zhou PK*. HIV-1 Tat impairs cell cycle control by targeting the Tip60, Plk1 and cyclin B1 ternary complex. Cell Cycle. 201211(6):1217-34.16.Zhang B, Huang B, Guan H, Zhang SM, Xu QZ, He XP, Liu XD, Wang Y, Shang ZF, Zhou PK*. Proteomic profiling revealed the functional networks associated with mitotic catastrophe of HepG2 hepatoma cells induced by 6-bromine-5-hydroxy-4-methoxybenzaldehyde. Toxicol Appl Pharmacol. 2011 252(3):307-17.17.Shang ZF, Huang B, Xu QZ, Zhang SM, Fan R, Liu XD, Wang Y, Zhou PK*. Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage. Cancer Res. 2010 70(9):3657-66.18.An J, Yang TY, Huang YC, Liu F, Sun JF, Wang Y, Xu QZ, Wu DC, Zhou PK. Strand-specific PCR of UV radiation-damaged genomic DNA revealed an essential role of DNA-PKcs in the transcription-coupled repair. BMC Biochemistry, 2011, 12:2. doi:10.1186/1471-2091-12-2. 1.766湖南省芙蓉学者特聘教授南华大学公共卫生学院教授、环境医学与放射卫生研究所所长中国毒理学会理事长国际放射防护委员会（ICRP）委员中国辐射防护学会常委中华医学会放射医学与防护分会常委Toxicology Research副主编Food and Chemical Toxicology副主编International Journal of Radiation Biology编辑顾问委员会委员中国科学院重离子束辐射生物医学重点实验室学术委员会主任中国航天医学基础与应用国家重点实验室学术委员会委员国家自然科学基金委生命科学部和医学科学部评审专家

教育背景 :
1980/09-1985/07 中南大学，湘雅医学院，学士1987/09-1990/07军事医学科学院，放射与辐射医学研究所，硕士，导师：魏康2001/09-2004/06军事医学科学院，放射与辐射医学研究所，博士，导师：吴德昌