导师姓名：尹然
性别：女
人气指数：108

所属院校：沈阳药科大学
所属院系：药学院
职称：副教授
导师类型：硕导
招生专业：药物分析学、药学（药物分析学方向）
研究领域： 研究方向一：基于系统生物学方法开展中药药效物质基础和作用机制研究研究方向二：中药质量控制方... [展开]


研究领域： 研究方向一：基于系统生物学方法开展中药药效物质基础和作用机制研究研究方向二：中药质量控制方法和药品质量标准研究研究方向三：体内药物分析方法和药代动力学研究 [收起]




通讯方式 :
办公电话：**
电子邮件：yinran100@126.com
通讯地址：辽宁省本溪高新技术产业开发区华佗大街26号


个人简述 :
尹然，女，博士，副教授。2003年毕业于沈阳药科大学，获药学(日语)专业理学学士学位，同年考取沈阳药科大学药物分析专业研究生，2005年获得硕博连读资格，2008年获药物分析学博士学位，毕业后留校任教。2012年被聘为沈阳药科大学副教授，现为药物分析专业硕士生导师。研究方向：中药质量控制方法、药效物质基础与作用机制研究，药品质量标准制定，药代动力学研究等。作为课题负责人主持了国家自然科学基金青年基金项目1项，辽宁省自然科学基金项目1项，辽宁省教育厅项目1项，沈阳药科大学中青年骨干人才培育计划项目1项；另外，作为项目主要成员参与承担国家自然科学基金项目，国家科技重大专项子课题，省、市各级科研项目共15项。目前已在国内外学术期刊和学术会议上发表研究论文36篇，其中SCI收录23篇，获辽宁省自然科学学术成果奖（学术论文类）1项；沈阳市自然科学学术成果奖（学术论文类）2项。

科研工作 :
近年来发表代表性论文(限第一作者或通讯作者，SCI须写明影响因子)：1.Fei Han, Yanting Li, Li Ma, Tianfeng Liu, Yawen Wu, Rui Xu, Aihua Song, Ran Yin*. A rapid and sensitive UHPLC-FT-ICR MS/MS method for identification of chemical constituents in Rhodiola crenulata extract, rat plasma and rat brain after oral administration. Talanta. 2016, 160:183-193. (IF=4.035)2.Fei Han, Yan-ting Li, Xin-juan Mao, Xiao-shu Zhang, Jiao Guan, Ai-hua Song*, Ran Yin*. Metabolic profile of salidroside in rats using high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. Analytical and Bioanalytical Chemistry. 2016, 408 (7)：1975-1981. (IF=3.125)3.Fei Han, Yanting Li, Xinjuan Mao, Rui Xu，Ran Yin*. Characterization of chemical constituents in Rhodiola Crenulate by high-performance liquid chromatography coupled with Fourier-transform ion cyclotron resonance mass spectrometer (HPLC-FT-ICR MS). J Mass Spectrom. 2016, 51:363-368. (IF=2.541)4.Heyun Zhu, Kaishun Bi, Fei Han, Jiao Guan, Xiaoshu Zhang, Xinjuan Mao, Longshan Zhao, Qing Li, Xiaohong Hou, Ran Yin*. Identification of the absorbed components and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma by ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. J Pharm Biomed Anal. 2015, 111:277-287. (IF=2.979)5.Ke-Lin Chen, Kai-Shun Bi, Fei Han, He-Yun Zhu, Xiao-Shu Zhang, Xin-Juan Mao, Ran Yin*. Evaluation of the protective effect of Zhi-Zi-da-Huang decoction on acute liver injury with cholestasis induced by α-naphthylisothiocyanate in rats. J Ethnopharmacol. 2015, 172:402-409. (IF=2.998)6.Zheng Tang, Ran Yin*, Kaishun Bi, Heyun Zhu, Fei Han, Kelin Chen, Fenrong Wang. Simultaneous quantitative determination of 20 active components in the traditional Chinese medicine formula Zhi-Zi-Da-Huang decoction by liquid chromatography coupled with mass spectrometry: application to study the chemical composition variations in different combinations. Biomed Chromatogr. 2015, 29 (9): 1406-1414. (IF=1.723)7.Heyun Zhu, Kaishun Bi, Fei Han, Jiao Guan, Zheng Tang, Kelin Chen, Longshan Zhao, Qing Li, Ran Yin*, Xiaohong Hou*. Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS: Application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats. J Chromatogr B. 2014, 960:116-125. (IF=2.694)8.Heyun Zhu, Ran Yin*, Fei Han, Jiao Guan, Xiaoshu Zhang, Xinjuan Mao, Longshan Zhao, Qing Li, Xiaohong Hou, Kaishun Bi*. Characterization of chemical constituents in Zhi-Zi-Da-Huang decoction by ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Sep Sci. 2014, 37 (23):3489-3496. (IF=2.594)9.Ran Yin, Fei Han, Zheng Tang, Ran Liu, Xu Zhao, Xiaohui Chen, Kaishun Bi*. UFLC–MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection. J Pharm Biomed Anal. 2013, 72:127-133. (IF=2.947)10.Ran Yin, Xin-Xiu Deng, Fei Han, Zhen Song, Wei-Ming Cheng, Xiao-Hui Chen, Kai-Shun Bi*. Determination of five components in Ixeris sonchifolia by high performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis. 2007, 43 (4): 1364-1369. (IF=2.761)