导师姓名：张之昊
性别：男
人气指数：1977

所属院校：中国药科大学
所属院系：中药学院
职称：副研究员
导师类型：硕导
招生专业：中药学（中药药理学）
研究领域： 慢性肾脏病机制及生物标志物的代谢组学研究；与肾脏病相关天然产物活性物质基础研究
研究领域： 慢性肾脏病机制及生物标志物的代谢组学研究；与肾脏病相关天然产物活性物质基础研究 [收起]




通讯方式 :
办公电话：**
电子邮件：zzh-198518@163.com
通讯地址：南京市江宁区龙眠大道639号，理学实验楼B楼


个人简述 :
张之昊，男，博士，2017年以特聘副研究员引进，硕士研究生导师。2010年毕业于中国药科大学药物化学系，同年加入澳门科技大学林瑞超教授课题组进行中药化学和代谢组学研究，并于2013年获颁博士学位。之后于密西西比大学，师从著名有天然产物化学家Ikhlas A. Khan教授开展博士后工作，后于2015年加入美国橡树林国家实验，师从著名生物学家Tim Tschaplinski教授开展博士后工作，进行代谢组学及生物能源转化研究。迄今已在国际知名学术期刊发表近十五篇学术论文，其中已发表第一作者论文10篇?(影响因子IF > 4.0的5篇)，专利一篇。

科研工作 :
代表性论文：1Zhi-Hao Zhang, Hua Chen, Nosratola D. Vaziri, Jia-Rong Mao, LiZhang, Xu Bai, Ying-Yong Zhao*. Metabolomic signatures of chronic kidneydisease of diverse etiologies in the rats and humans. Journal of Proteome Research 2016, 15：3802-3812. IF = 4.2682Zhi-Hao Zhang, Zulfiqar Ali, Shabana I. Khan, Ikhlas A. Khan*. Cytotoxic monacolins from red yeast rice, a Chinese medicine and food. Food Chemistry2016, 202: 262-268. IF = 4.5293Zhi-Hao Zhang#, Xiaoyan Wang#*, Jingcheng Wang, Zhiying Jia, YuminLiu, Xie Xie, Chongchong Wang, Wei Jia*. Metabonomics approach to assessingthe metabolism variation and endoexogenous metabolic interaction ofginsenosides in cold stress rats. Journal of Proteome Research 2016, 15: 1842-1852. IF = 4.2684Zhi-Hao Zhang, Feng Wei, Nosratola D. Vaziri, Xian-Long Cheng, XuBai, Rui-Chao Lin, Ying-Yong Zhao*. Metabolomics insights into chronic kidneydisease and modulatory effect of rhubarb against tubulointerstitial fibrosis. Scientific reports 2015, 5: 14472. IF = 5.2285Zhi-Hao Zhang, Ying-Yong Zhao, Xian-long Cheng, Zhong Dai, Chao Zhou,Xu Bai, Rui-Chao Lin*.General toxicity of Pinellia ternata (Thunb.) Berit.in rat: a metabonomic method for profiling of serum metabolic changes. Journalof Ethnopharmacology 2013, 149: 303-310. IF = 2.9396Zhi-Hao Zhang, Nosratola D. Vaziri, Feng Wei, Xian-Long Cheng, Xu Bai, Ying-Yong Zhao*. An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure.Scientific reports2016 , 6: 22151. IF = 5.2287Zhi-Hao Zhang, Ying-Yong Zhao, Xian-Long Cheng, Rui-Chao Lin*, Zhong Dai, Chao Zhou. Metabonomic study of biochemical changes in the rat urine induced by Pinellia ternata (Thunb.) Berit. Journal of Pharmaceutical and Biomedical Analysis 2013, 85: 186-193. IF = 3.2558Zhi-Hao Zhang#, Jia-Rong Mao#, Hua Chen#, Wei Su, Yuan Zhang, Li Zhang, Dan-Qian Chen, Ying-Yong Zhao*, Nosratola D.Vaziri*. Removal of uremic retention products by hemodialysis is coupled with indiscriminate loss of vital metabolites. Clinical Biochemistry 2017, 50: 1078-1086. IF = 2.434