导师姓名：刘夫锋
性别：男
人气指数：35

所属院校：天津科技大学
所属院系：生物工程学院
职称：教授
导师类型：
招生专业：药理学
研究领域： [1]蛋白质聚集及抑制[2]酶工程
研究领域： [1]蛋白质聚集及抑制[2]酶工程 [收起]




通讯方式 :
电子邮件：fufengliu@tust.edu.cn


个人简述 :
获奖情况先后荣获天津大学本科毕业设计优秀指导教师Hong Kong Scholars Annual Symposium Best poster津大学北洋学者青年骨干教师（第一批）天津大学第九届青年教师讲课大赛，天津大学三等奖天津大学第九届青年教师讲课大赛，化工学院一等奖宝舜奖教金天津大学大学生创新性实践计划项目优秀指导教师天津大学本科毕业设计优秀指导教师。

科研工作 :
先后发表SCI检索论文50余篇，参编教材或专著1部，授权或申请发明专利7项。近年来发表的主要代表性学术论文有：[1] N. Xiong X.-Y. Dong J. Zheng F.-F. Liu* and Y. Sun*. Design of LVFFARK and LVFFARK- functionalized nanoparticles for inhibiting amyloid β-protein fibrillation and cytotoxicity ACS Applied Materials & Interfaces 2015 7(10): 5650-5662 SCI 1区 Impact factor: 8.097[2] Junying Wang Ying Zhang Xingji Wang Jinzhao Shang Yu Li Huitu Zhang Fuping Lu* F.-F. Liu*. Biochemical characterization and molecular mechanism of acid denaturation of a novel α-amylase from Aspergillus niger Biochemical Engineering Journal 2018 137: 222-231. SCI 2区 Impact factor: 3.226[3] H. Qin Z. Zhu Z. Ma P. Xu Q. Guo S. Li J. Wang S. Mao F.-F. Liu* F.-P. Lu*. Rational design of cholesterol oxidase for efficient bioresolution of cholestane skeleton substrates Scientific Reports 2017 7: 16375 SCI 3区 Impact factor: 4.122[4] Y.-L. Tu S. Ma F.-F. Liu * Y. Sun X.-Y. Dong*. Hematoxylin Suppresses Amyloid β-Protein Aggregation and Reduces Amyloid Cytotoxicity The Journal of Physical Chemistry B 2016 120 (44) 11360–11368. SCI 2区 Impact factor: 3.603[5] N. Zhang F.-F. Liu* X.-Y. Dong and Y. Sun*. Synergistic inhibition of acid-induced protein denaturation by trehalose and NaCl: thermodynamic and kinetic studies Biochemical Engineering Journal 2014 91: 231-239 SCI 2区 Impact factor: 3.226[6] W.-J. Du J.-J. Guo M.-T. Gao S.-Q. Hu X.-Y. Dong Y.-F. Han F.-F. Liu* S. Jiang* Y. Sun*. Brazilin inhibits amyloid β-protein fibrillogenesis remodels amyloid fibrils and reduces amyloid cytotoxicity Scientific Reports 2015 5: 7992. SCI 2区 Impact factor: 5.578[7] N. Xiong X.-Y. Dong J. Zheng F.-F. Liu* and Y. Sun*. Design of LVFFARK and LVFFARK-functionalized nanoparticles for inhibiting amyloid β-protein fibrillation and cytotoxicity ACS Appl. Mater. Inter. 2015 7(10): 5650-5662. SCI 1区 Impact factor: 7.145[8] N. Zhang F.-F. Liu* X.-Y. Dong and Y. Sun*. Synergistic inhibition of acid-induced protein denaturation by trehalose and NaCl: thermodynamic and kinetic studies Biochemical Engineering Journal 2014 91: 231-239. SCI 2区 Impact factor: 2.467[9] W.-W. Zhao F.-F. Liu* Q.-H. Shi X.-Y. Dong and Y. Sun*. Biomimetic design of affinity peptide ligands for human IgG based on Protein A-IgG complex. Biochemical Engineering Journal 2014 88: 1-11. SCI 2区 Impact factor: 2.467[10] N. Zhang F.-F. Liu* X.-Y. Dong and Y. Sun*. Counteraction of Trehalose on Urea-Induced Protein Unfolding: Thermodynamic and Kinetic Studies Biochemical Engineering Journal 2013 79(15): 120-128. SCI 2区 Impact factor: 2.467[11] J.-J. Guo# W.-Q. Sun# F.-F. Liu*. Brazilin inhibits the Zn2+-mediated aggregation of amyloid β-protein and alleviates cytotoxicity Journal of Inorganic Biochemistry 2017 177: 183-189 SCI 2区 Impact factor:3.063[12] S.-Y. Chang F.-F. Liu* X.-Y. Dong and Y. Sun*. Molecular insight into conformational transmission of human P-glycoprotein The Journal of Chemical Physics 2013 139（22）：225102. (Cover page) SCI 2区 Impact factor: 3.122[13] F.-F. Liu B. Huang X.-Y. Dong and Y. Sun*. Molecular Basis for the Dissociation Dynamics of Protein A-Immunoglobulin G1 Complex. Plos One 2013 8(6): e66935. SCI 2区 Impact factor: 4.411[14] N. Zhang F.-F. Liu* X.-Y. Dong and Y. Sun*. Equilibrium and kinetic studies of the counteraction of trehalose on acid-induced protein unfolding. Biochemical Engineering Journal 2013 70: 188-195. SCI 2区 Impact factor: 2.467[15] N. Zhang F.-F. Liu* X.-Y. Dong and Y. Sun*. Molecular Insight into the Counteraction of Trehalose on Urea-Induced Protein Denaturation Using Molecular Dynamics Simulation. The Journal of Physical Chemistry B 2012 116: 7040-7047. SCI 2区 Impact factor: 3.603[16] F.-F. Liu Z. Liu S. Bai X.-Y. Dong and Y. Sun*. Exploring the inter-molecular interactions in amyloid-β protofibril with molecular dynamics simulations and molecular mechanics Poisson-Boltzmann surface area free energy calculations. The Journal of Chemical Physics 2012 Apr 14 136 (14):145101. SCI 2区 Impact factor: 3.122[17] S.-H. Wang F.-F. Liu X.-Y. Dong Y. Sun*. Calorimetric and Spectroscopic Studies of the Interactions between Insulin and (-)-Epigallocatechin-3-gallate. Biochemical Engineering Journal 2012 62: 70-78. SCI 2区 Impact factor: 2.467[18] B. Huang F.-F. Liu* X.-Y. Dong Y. Sun*. Molecular Mechanism of the Effects of Salt and pH on the Affinity between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations The Journal of Physical Chemistry B 2012 116 424-433. SCI 2区 Impact factor: 3.603[19] Y. Sun* Q.-H. Shi L. Zhang G. Zhao F. -F. Liu: Adsorption and chromatography. In ed. Comprehensive Biotechnology Vol. 2 Chapter 2.47. pp. 665-679. Elsevier 2011.[20] F.-F. Liu X. -Y. Dong L. Z. He A. P. J. Middelberg Y. Sun*: Molecular Insight into Conformational Transition of Amyloid β-Peptide 42 Inhibited by (-)-Epigallocatechin-3-gallate Probed by Molecular Simulations. The Journal of Physical Chemistry B 2011 115 11879-11887. SCI 2区 Impact factor: 3.603[21] B. Huang F.-F. Liu X.-Y. Dong Y. Sun*. Molecular Mechanism of the Affinity Interactions between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations. The Journal of Physical Chemistry B 2011 115 4168-4176. SCI 2区 Impact factor: 3.603[22] S.-H. Wang F.-F. Liu X.-Y. Dong Y. Sun*. Thermodynamic Analysis of the Molecular Interactions between Amyloid β-Peptide 42 and (-)-Epigallocatechin-3-gallate. The Journal of Physical Chemistry B 2010 114: 11576-11583. SCI 2区 Impact factor: 3.603[23] F.-F. Liu J. Luo L. Zhang X.-Y. Dong Y. Sun*: Molecular basis for polyol-induced protein stability revealed by molecular dynamics simulations. Journal of Chemical Physics 2010 132: 225103. SCI 2区 Impact factor: 3.122[24] F.-F. Liu J. Luo X.-Y. Dong Y. Sun*: BIOT 146-Molecular dynamics simulation of the inhibition effect of trehalose on the nucleation and elongation of amyloid beta-peptide oligomers. Abstracts of papers of the American Chemical Society Vol: 238 146-BIOT Aug 16 2009. SCI检索[25] F.-F. Liu J. Luo X.-Y. Dong Y. Sun*: Molecular insight into the inhibition effect of trehalose on the nucleation and elongation of Amyloid β-peptide oligomers. The Journal of Physical Chemistry B 2009 113 (32): 11320-11329. SCI 2区 Impact factor: 3.603[26] Y. Sun* F.-F. Liu Q.-H. Shi: Approaches to high-performance preparative chromatography of proteins Advances in Biochemical Engineering /Biotechnology 2009 113: 217-254. SCI 2区 Impact factor: 2.600[27] F.-F. Liu X.-Y. Dong Y. Sun*: Molecular mechanism for the effects of trehalose on β-hairpin folding revealed by molecular dynamics simulation. Journal of Molecular Graphics & Modelling 2008 27 (4): 421-429. SCI 3区 Impact factor: 2.177[28] F.-F. Liu X.-Y. Dong Y. Sun*: Discovery and design of affinity ligands for protein chromatography. Journal of Biotechnology 2008 136: 497. SCI 2区 Impact factor: 3.037[29] F.-F. Liu X.-Y. Dong T. Wang Y. Sun*: Rational design of peptide ligand for affinity chromatography of tissue-type plasminogen activator by the combination of docking and molecular dynamics simulations. Journal of Chromatography A 2007 1175 (2): 249-258. SCI 2区 Impact factor: 4.467[30] F.-F. Liu T. Wang X.-Y. Dong Y. Sun*: Rational design of affinity peptide ligand by flexible docking simulation. Journal of Chromatography A 2007 1146 (1): 41–50. SCI 2区 Impact factor: 4.467