导师姓名：徐进
性别：男
人气指数：781

所属院校：宁波大学
所属院系：医学院
职称：副教授
导师类型：
招生专业：劳动卫生与环境卫生学
研究领域： 环境毒理学
研究领域： 环境毒理学 [收起]




通讯方式 :
电子邮件：xujin1@nbu.edu.cn


个人简述 :
宁波大学医学院预防医学系副教授，博士、博士后。2010年入选“浙江省高校优秀青年教师资助计划”；2011年入选浙江省“新世纪151人才工程”；2012年入选宁波市“领军和拔尖人才培养工程”；2013年入选“浙江省优秀中青年学科带头人”。“基于细胞应答网络的铅毒性效应研究”获得2014年浙江省自然科学二等奖、2013年宁波市科技进步二等奖。主持完成国家自然科学基金、浙江省自然科学基金、中国博士后科学基金、浙江省教育厅、国家重点实验室开放课题和宁波市自然科学基金。国家自然科学基金评审专家，浙江省自然科学基金二审专家，World Journal of Hypertension编委，PLoS One、Molecular Biology reports、Food and Chemical Toxicology等十余本SCI杂志审稿专家。在国内外核心期刊发表学术论文70余篇，SCI收录论文35篇，单篇最高影响因子超过14。

主要研究方向：基于细胞应答反应的毒物机理研究，毒物基因组学。



科研工作 :
1. Ji LD, Li JY, Yao BB, Cai XB, Shen QJ, Xu J. Are genetic polymorphisms in the renin-angiotensin-aldosterone system associated with essential hypertension? Evidence from genome-wide association studies. Journal of human hypertension, 2017.

2. Zhou M, Feng M, Fu LL, Ji LD, Zhao JS, Xu J. Toxicogenomic analysis identifies the apoptotic pathway as the main cause of hepatotoxicity induced by tributyltin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2016, 97: 316-326.

3. Xu J, Qian HX, Hu SP, Liu LY, Zhou M, Feng M, et al. Gender-Specific Association of ATP2B1 Variants with Susceptibility to Essential Hypertension in the Han Chinese Population. BioMed research international, 2016, 2016: **.

4. Tu WW, Ji LD, Qian HX, Zhou M, Zhao JS, Xu J. Tributyltin induces disruption of microfilament in HL7702 cells via MAPK-mediated hyperphosphorylation of VASP. Environmental toxicology, 2016, 31 (11): 1530-1538.

5. Ji LD, Tang NL, Xu J. AGTR1 has undergone natural selection in Euro-Asian populations in relation to ambient temperature that predisposes Chinese populations to essential hypertension. International journal of cardiology, 2016, 209: 278-280.

6. Zhou M, Tu WW, Xu J. Mechanisms of microcystin-LR-induced cytoskeletal disruption in animal cells. Toxicon : official journal of the International Society on Toxinology, 2015, 101: 92-100.

7. Zeng J, Tu WW, Lazar L, Chen DN, Zhao JS, Xu J. Hyperphosphorylation of microfilament-associated proteins is involved in microcystin-LR-induced toxicity in HL7702 cells. Environmental toxicology, 2015, 30 (8): 981-988.

8. Su J, Li X, Yu Q, Liu Y, Wang Y, Song H, et al. Association of P2Y12 gene promoter DNA methylation with the risk of clopidogrel resistance in coronary artery disease patients. BioMed research international, 2014, 2014: 450814.

9. Ji LD, Xu WN, Chai PF, Zheng W, Qian HX, Xu J. Polymorphisms in the CISH gene are associated with susceptibility to tuberculosis in the Chinese Han population. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2014, 28: 240-244.

10. Zheng W, Ji LD, Xing WH, Tu WW, Xu J. [Advances in genome-wide association study of tuberculosis]. Yi chuan = Hereditas, 2013, 35 (7): 823-829.

11. Zhang LN, Ji LD, Fei LJ, Yuan F, Zhang YM, Xu J. Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population. BioMed research international, 2013, 2013: 451094.

12. Xu J, Ji LD, Zhang LN, Dong CZ, Fei LJ, Hua S, et al. Lack of association between STK39 and hypertension in the Chinese population. Journal of human hypertension, 2013, 27 (5): 294-297.

13. Ji LD, Chai PF, Zhou BB, Tang NL, Xing WH, Yuan F, et al. Lack of association between polymorphisms from genome-wide association studies and tuberculosis in the Chinese population. Scandinavian journal of infectious diseases, 2013, 45 (4): 310-314.

14. Ji L, Cai X, Zhang L, Fei L, Wang L, Su J, et al. Association between polymorphisms in the renin-angiotensin-aldosterone system genes and essential hypertension in the Han Chinese population. PloS one, 2013, 8 (8): e72701.

15. Yuan F, Xu J, Ji LD, Fei LJ, Liu PP, Zhang LN. [Application of Tm-shift genotyping method in genetic studies]. Yi chuan = Hereditas, 2012, 34 (11): 1484-1490.

16. Ji LD, Qiu YQ, Xu J, Irwin DM, Tam SC, Tang NL, et al. Genetic adaptation of the hypoxia-inducible factor pathway to oxygen pressure among eurasian human populations. Molecular biology and evolution, 2012, 29 (11): 3359-3370.

17. Fei LJ, Ji LD, Zhang LN, Hua S, Jin JQ, Xu J. [Application of SNPstream for medical genetics research]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2012, 29 (1): 9-12.

18. Chen DN, Zeng J, Wang F, Zheng W, Tu WW, Zhao JS, et al. Hyperphosphorylation of intermediate filament proteins is involved in microcystin-LR-induced toxicity in HL7702 cells. Toxicology letters, 2012, 214 (2): 192-199.

19. Xu J, Ji LD, Xu LH. Endoplasmic reticulum may not be involved in the lead-induced apoptosis in PC 12 cells in vitro. Environmental toxicology, 2010, 25 (1): 55-60.

20. Ji LD, Zhang LN, Shen P, Wang P, Zhang YM, Xing WH, et al. Association of angiotensinogen gene M235T and angiotensin-converting enzyme gene I/D polymorphisms with essential hypertension in Han Chinese population: a meta-analysis. Journal of hypertension, 2010, 28 (3): 419-428.

21. Ji LD, Xu J, Wu DD, Xie SD, Tang NL, Zhang YP. Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations. Journal of pineal research, 2010, 48 (2): 133-141.

22. Xu J, Ji LD, Xu LH. Lead-induced apoptosis in PC 12 cells: involvement of p53, Bcl-2 family and caspase-3. Toxicology letters, 2006, 166 (2): 160-167.
浙江省毒理学会理事

宁波市预防医学会理事
1. 国家自然科学基金《细胞骨架相关的微囊藻毒素毒性机理研究》2. 浙江省自然科学基金《中间纤维信号通路相关的微囊藻毒素毒性机理研究》

3. 浙江省公益技术应用研究计划《海洋环境污染物三丁基锡的毒性机制研究》

4. 浙江省高等教育教学改革项目《构建研究型大学创新创业人才培养体系的探索》

5. 中国博士后科学基金《肾素-血管紧张素-醛固酮系统基因多态性与高血压的关联研究》

6. 国家重点实验室开放课题《高血压易感基因的分子进化研究》

7. 宁波市自然科学基金《细胞骨架相关的三丁基锡毒性机制研究》

8. 宁波市自然科学基金《肾素-血管紧张素系统基因多态性与原发性高血压的关联研究》
2014年度浙江省自然科学二等奖，《基于细胞应答网络的铅毒性机》，排名第一

2015年宁波市青年科技奖

2013年度宁波市科技进步奖二等奖《基于细胞应答网络的铅毒性效应研究》，排名第一

2011年浙江省青年教师教学技能比赛优秀奖